Neurovascular Assessment

Neurovascular assessment is a structured clinical evaluation of blood flow, nerve function, and tissue status in an extremity, helping identify changes that may threaten limb health. It combines comparison of both sides with checks of pulses, capillary refill, skin color and temperature, sensation, movement, and pain to detect impaired circulation or neurological function. Clinicians use serial assessments after trauma, surgery, fractures, or cast and splint application, when swelling or pressure can compromise vessels and nerves. Documenting trends supports timely escalation and treatment, making neurovascular assessment an essential component of bedside monitoring and patient safety.

Neurovascular Assessment - Related Videos

Research

JoVE EoE - Neuropathology

Generation of a Neurovascular Unit

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2025

Suspend the cell mixture in an extracellular matrix or ECM solution.

A Method for the Isolation of Neurovascular Units from Rat Brain

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2025

This video demonstrates the process of isolating brain microvessels from euthanized rats. It includes the dissection of the brain, cleaning of the tissue, and mechanical digestion, followed by repeated centrifugation to isolate the pure fraction of microvessels.

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

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Cited by 14 •

2015

This protocol describes repetitive hypoxic preconditioning, or brief exposures to systemic hypoxia that reduce infarct volumes and blood-brain barrier disruption following transient middle cerebral artery occlusion in mice. It also details dual quantification of infarct volume and blood-brain barrier disruption after stroke to assess the efficacy of neurovascular protection.

The Analysis of Neurovascular Remodeling in Entorhino-hippocampal Organotypic Slice Cultures

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Cited by 11 •

2014

A protocol for entorhino-hippocampal organotypic slice cultures, which allows reproducing many aspects of ischemic brain injury, is presented. By studying changes of the neurovasculature in addition to changes in the neurons, this protocol is a versatile tool to study plastic changes in neural tissue after injury.

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

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Cited by 9 •

2012

Blood-brain barrier disruption aids the delivery of certain drugs to the brain. Mannitol delivered intra-arterially shrinks cells surrounding blood vessels in order to physically disrupt the barrier.

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