Skin Changes Evaluation
Skin Changes Evaluation - Related Videos
07:56
A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
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Cited by 13 •
2014
Vascularization is key to approaches in successful tissue engineering. Therefore, reliable technologies are required to evaluate the development of vascular networks in tissue-constructs. Here we present a simple and cost-effective method to visualize and quantify vascularization in vivo.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
09:30
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
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Cited by 44 •
2016
The protocol describes a new method to disaggregate human tissues and to create autologous micro-grafts that, combined with collagen sponges, give rise to human bio-complexes ready to use in the treatment of skin lesions. Further, this system preserves cell viability of micro-grafts at different times after mechanical disaggregation.
08:43
Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
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Cited by 52 •
2018
Here, we present a protocol to measure the vascular leakage induced by intradermal administration of permeability promoting agents into the murine skin. This technique can be used to determine the ability of molecules to promote or inhibit vascular leakage or to study the molecular mechanisms that regulate vascular permeability.
05:44
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Cited by 2 •
2025
Skin lesions are common and important features in many rheumatic diseases, and biopsy with pathological analysis plays a critical role in diagnosis. This article provides a detailed overview of the standardized skin biopsy procedure and, using discoid lupus erythematosus as an example, highlights the essential role of dermatopathology in diagnosing rheumatic diseases.
FAQs
Patient history adds context that visual findings alone cannot provide. Clinicians consider when an alteration began, whether it is progressing, and which symptoms accompany it, such as changes in sensation. This timeline helps organize possible explanations, including inflammatory, infectious, allergic, traumatic, or neoplastic conditions, and can influence whether further evaluation is appropriate.
Clinicians assess distribution, borders, symmetry, scale, ulceration, color, texture, shape, surface integrity, and sensation as related but distinct findings. Examining these features together helps characterize the lesion rather than relying on one visible attribute. Their combination can support clinical differentiation and identify changes that merit additional investigation or closer follow-up.
Inspection identifies visible characteristics, while palpation contributes information about texture and other physical qualities that may not be apparent on the surface. Dermoscopy or biopsy can provide additional information when the initial assessment is insufficient. These tools extend the clinical examination and may help guide diagnostic decisions without replacing the need for history and direct assessment.
A practical workflow begins with patient history, followed by systematic inspection and palpation of the affected area. The clinician records features such as onset, progression, distribution, borders, symmetry, scale, ulceration, and associated symptoms. If indicated, dermoscopy or biopsy adds information, while the overall findings guide diagnosis, treatment selection, monitoring, and communication.
Consistent documentation creates a reliable record of a lesion’s observed characteristics at each assessment. Comparing current findings with earlier observations can reveal progression or other meaningful change that may not be apparent from a single examination. This longitudinal information supports monitoring, helps inform treatment selection, and improves communication among healthcare professionals involved in care.
Evaluation can identify findings that require urgent attention while also helping clinicians distinguish conditions with inflammatory, infectious, allergic, traumatic, or neoplastic patterns. The assessment therefore supports more than lesion description: it contributes to diagnostic direction and treatment selection. When the initial examination leaves important uncertainty, additional information from dermoscopy or biopsy may be indicated.