A Full Skin Defect Model to Evaluate Vascularization of Biomaterials <em>In Vivo</em>

Thilo L. Schenck; Myra N. Ch&#225;vez; Alexandru P. Condurache; Ursula Hopfner; Farid Rezaeian; Hans-G&#252;nther Machens; Jos&#233; T. Ega&#241;a

doi:10.3791/51428

Journal

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Bioengineering

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A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

12,112 Views

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07:56 min

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August 28, 2014

DOI:

10.3791/51428-v

DOI:

10.3791/51428-v

•

07:56 min

August 28, 2014

•

3 Views

Thilo L. Schenck¹, Myra N. Chávez¹, Alexandru P. Condurache², Ursula Hopfner¹, Farid Rezaeian³, Hans-Günther Machens¹, José T. Egaña^1,4

¹Department of Plastic Surgery and Hand Surgery, University Hospital rechts der Isar,Technische Universität München, ²Institute for Signal Processing,University of Lübeck, ³Department of Plastic Surgery and Hand Surgery,University Hospital Zürich, ⁴FONDAP Center for Genome Regulation, Facultad de Ciencias,Universidad de Chile

Summary

Vascularization is key to approaches in successful tissue engineering. Therefore, reliable technologies are required to evaluate the development of vascular networks in tissue-constructs. Here we present a simple and cost-effective method to visualize and quantify vascularization in vivo.