Urinary Bladder
Urinary Bladder - Related Videos
11:46
Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Cited by 19 •
2014
Approximately 3-8 million people in the United States suffer from interstitial cystitis/bladder pain syndrome (IC/BPS), a debilitating condition characterized in part by pelvic pain. In order to study nervous system contributions to the condition, a physiological model of urinary bladder pain is used in mice and rats.
01:23
Urinary Bladder
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2024
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor. In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
03:02
Urine Depletion and Bladder Rinsing in Mouse Model: A Catheter-based Procedure to Empty and Wash Murine Urinary Bladder
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2023
In this video, we describe a catheter-based procedure to empty and rinse the urinary bladder of a mouse model. The prepped mouse can then be used for further experimental procedures.
04:51
Isolation and Culture of Primary Neurons and Glia from a Rat Urinary Bladder
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2025
This video demonstrates a technique for generating a primary culture of neurons and glia from a rat's urinary bladder. It outlines the steps involved in tissue preparation, enzymatic digestion to obtain single cells, and culturing the cells in a neuron-specific medium to establish a primary neuronal and glial culture.
03:45
Detrusor Smooth Muscle Cell Isolation: An Enzymatic Digestion Procedure to Obtain DSM Cells from Human Urinary Bladder Specimens
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2023
In this video, we demonstrate the isolation of detrusor smooth muscle cells from human urinary bladder specimens using a two-step sequential enzymatic treatment.
FAQs
Bladder compliance allows the wall to expand as urine accumulates without a proportionate rise in pressure. This storage property depends on the coordinated behavior of the muscular wall and its urothelial lining. Clinically, evaluating how well the bladder accommodates filling helps assess whether storage function is contributing to urinary symptoms or dysfunction.
Effective emptying requires reciprocal coordination: neural signaling promotes detrusor contraction while the internal and external urethral sphincters relax. If contraction and outlet relaxation do not occur in the necessary sequence, urine elimination can become impaired. This relationship provides a physiological basis for assessing retention, incontinence, and neurogenic bladder dysfunction.
The functional filling threshold marks a transition between urine storage and coordinated elimination. Before that point, the bladder accommodates increasing volume at low pressure; afterward, neural signaling supports detrusor activation and sphincter relaxation. Recognizing this transition helps clinicians interpret symptoms and functional test results in patients with abnormal bladder control.
No single assessment captures every aspect of bladder function. Symptoms describe the patient’s experience, urinalysis examines the urine, imaging evaluates relevant structures, urodynamic testing assesses functional behavior, and endoscopy permits direct inspection. Combining these approaches can support a more complete clinical assessment than relying on one source of information alone.
Urodynamic testing focuses on how the bladder functions during filling and emptying, whereas endoscopy provides direct visual assessment of the bladder interior. Their roles are therefore complementary rather than interchangeable. In clinical evaluation, using the appropriate test can help distinguish functional abnormalities from findings that require direct internal examination.
Assessment is relevant whenever symptoms or findings suggest impaired storage, emptying, or urinary tract pathology. The clinical context includes urinary tract infection, incontinence, retention, neurogenic dysfunction, stones, and bladder cancer. Understanding bladder anatomy and physiology helps clinicians select appropriate evaluations and supports diagnosis and management across these conditions.