Micro-pump Delivery

Micro-pump delivery is a method for transporting precise, small-volume fluids through microscale devices, where controlled dosing is essential for reproducible experiments. A micro-pump generates fluid movement by applying pressure or mechanical displacement, often directing reagents through narrow channels at programmed flow rates and times. In genetics, this approach can deliver nucleic acids, enzymes, culture media, or other reagents to cells and experimental systems while limiting waste and exposure. Its fine control supports automated workflows, localized treatment, and repeatable sample handling, making it useful for gene-transfer studies, molecular assays, and emerging lab-on-a-chip platforms.

Micro-pump Delivery - Related Videos

Research

JoVE EoE - Rodent Models

Continuous Drug Infusion System in Mouse Model: A Surgical Procedure to Implant Micro-osmotic Pump Infusion System in the Mouse Brain for Continuous Drug Delivery

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2025

In this video, we demonstrate the assembly of a micro-osmotic pump brain infusion system followed by its surgical implantation in the mouse skull. This system enables continuous delivery of potential drugs and facilitates the study of their effects on the brain and brain tissue.

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

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Cited by 1 •

2009

A novel microfluidic system has been developed using the phenomenon of passive pumping and a user controlled fluid delivery system. This microfluidic system has the potential to be used in a wide variety of biological applications given its low cost, ease of use, volumetric precision, high speed, repeatability and automation.

Osmotic Pump-Based Neurotherapeutic Drug Delivery in a Demyelinated Mouse Model

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2025

Source: Wang, X. et. al., Osmotic Pump-based Drug-delivery for In Vivo Remyelination Research on the Central Nervous System. J. Vis. Exp. (2021)This video demonstrates the method for delivering neurotherapeutic drugs using an osmotic pump in a demyelinated mouse model. The controlled drug release promotes remyelination by activating myelin-producing cells in the corpus callosum.

Research

JoVE Journal - Neuroscience
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Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions

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Cited by 10 •

2016

In order to study brain reorganization under pathological conditions we used miniosmotic pumps for direct protein delivery into the brain circumventing the blood brain barrier. Tract tracers are then injected to study alterations in brain connectivity under the influence of the protein.

Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging

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Cited by 9 •

2013

We show here the in vivo insertion of an osmotic pump for constant local drug delivery and the creation of hindlimb ischemia in a mouse model. Moreover, the hindlimb vasculature is perfused with Microfil, a silicone radiopaque agent, to prepare for micro-computed tomography (micro-CT) imaging.

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