Adhesion Fibrosis
Adhesion Fibrosis - Related Videos
01:14
Adhesion
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2019
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules. Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
08:56
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Cited by 300 •
2015
Disruption of bile flow results in severe inflammatory cholestatic liver injury with a characteristic time-dependent sequence of morphological alterations. Here we present a protocol for the surgical ligation of the common bile duct in mice that allows to induce a strong fibrotic response after 21 to 28 days.
07:40
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Cited by 3 •
2016
This flow adhesion assay provides a simple, high impact model of T cell-epithelial cell interactions. A syringe pump is used to generate shear stress, and confocal microscopy captures images for quantification. The goal of these studies is to effectively quantify T cell adhesion using flow conditions.
02:48
Preparation of Artificial Sputum Medium to Emulate Cystic Fibrosis Lung Sputum Ex Vivo
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2025
Source: Vieira, J., et al. Design and Development of a Model to Study the Effect of Supplemental Oxygen on the Cystic Fibrosis Airway Microbiome. J. Vis. Exp. (2021).This video demonstrates the preparation of an artificial sputum medium that mimics the viscosity, nutrient composition, and pH of cystic fibrosis lung sputum. The resulting medium provides a physiologically relevant platform for ex vivo studies.
06:44
Creation of Abdominal Adhesions in Mice
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Cited by 9 •
2016
Abdominal adhesions that form after surgery are a major cause of pain, infertility, and hospitalization and reoperation for small bowel obstruction. Our surgical procedure for creating abdominal adhesions in mice is a reliable tool to study the mechanisms underlying the formation of adhesions.
FAQs
Tissue injury or persistent inflammation activates fibroblasts at damaged surfaces. These cells produce excess collagen and other extracellular-matrix components, which become organized across the injured areas. As the matrix accumulates and stabilizes, it can create stronger abnormal connections between tissues. This mechanism explains why ongoing inflammation may sustain or intensify postoperative and disease-associated scarring.
Fibrinolysis helps break down fibrin-based material involved in tissue repair. When fibrinolysis is reduced, early deposits are less effectively cleared, giving collagen and other extracellular-matrix components more opportunity to become organized and stable. Consequently, the resulting attachment may persist rather than resolve, increasing the likelihood of dense scarring and prolonged restriction between normally separate structures.
By joining surfaces that normally move independently, adhesion fibrosis can distort local anatomy and restrict movement. The resulting tethering may interfere with the normal position or motion of involved organs, potentially impairing their function. These structural changes also matter clinically because altered anatomy can make later evaluation or operative access more difficult.
The principal influences identified are the severity or presence of tissue injury, persistence of inflammation, fibroblast activation, extracellular-matrix production, and the effectiveness of fibrinolysis. Injury and inflammation promote matrix deposition, whereas reduced fibrinolysis favors stabilization. Together, these processes determine whether repair remains limited or progresses toward dense, pathologic attachment.
Medical evaluation focuses on recognizing abnormal tissue attachment, distorted anatomy, restricted movement, and impaired organ function in the relevant clinical setting. Postoperative history and evidence of chronic inflammation help establish context, while the suspected structural effects guide assessment. This evaluation is important because adhesions may also complicate subsequent procedures by altering normal anatomic relationships.
Established fibrous attachments can obscure or distort normal anatomy, making later procedures more complicated. Awareness of this possibility helps clinicians interpret symptoms and structural findings in patients with prior surgery or chronic inflammatory disease. The broader clinical goal is to support prevention, diagnosis, and management strategies that limit functional impairment and reduce complications associated with abnormal scarring.