Analgesic Care

Analgesic care is the clinical assessment and management of pain using medications and supportive interventions to improve comfort, function, and quality of life. Its mechanisms depend on the approach: nonsteroidal anti-inflammatory drugs reduce cyclooxygenase activity and prostaglandin production, while opioids activate receptors that decrease pain signaling and perception; nonpharmacological measures can further modify sensory and emotional responses. In medicine, analgesic care is tailored to pain severity, cause, duration, patient characteristics, and treatment risks. Appropriate selection, dosing, monitoring, and reassessment can support recovery while reducing adverse effects, medication interactions, and the potential for misuse or inadequate pain control.

Analgesic Care - Related Videos

Research

JoVE EoE - Neurotherapeutics

Synergistic Effect of Intracranial and Intraperitoneal Delivery of Analgesic Drugs on Thermal Pain Response in a Rat

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2025

Source: Martinez, E., et al. Intracranial Pharmacotherapy and Pain Assays in Rodents. J. Vis. Exp. (2019).This video demonstrates the intracranial administration of an analgesic drug in an anesthetized rat with a pre-implanted guide cannula in the prefrontal cortex. An additional analgesic drug is co-administered intraperitoneally. Following recovery, the rat’s thermal pain response is assessed using Hargreave’s apparatus, where paw withdrawal latency is measured to evaluate the analgesic...

Research

JoVE Journal - Neuroscience
Free Sample

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Cited by 43 •

2014

We describe a protocol to examine the development of opioid-induced hyperalgesia and tolerance in mice. Based on the measurement of thermal and mechanical nociceptive responses of naïve and morphine-treated animals, it allows to quantify the increase in pain sensitivity (hyperalgesia) and decrease in analgesia (tolerance) associated with chronic opiate administration.

Education

JoVE Core - Pharmacology

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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2024

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...

Rabbit Preoperative Preparation, Surgical Procedures, and Postoperative Care

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2026

All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Preoperative Preparation The initial assessment should include observation of alertness, posture, gait, and grooming behavior, as changes in these parameters may indicate underlying health issues. Body weight should be recorded...

Opioid Analgesics: Morphine and Other Natural Cogeners

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2024

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...

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