Bis Monitoring
Bis Monitoring - Related Videos
11:42
Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
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Cited by 2 •
2012
The efficient solid-phase peptide synthesis of a functionalized bis-peptide trimer utilizing a "safety catch" cleavage procedure from HMBA resin is described.
08:01
Sulfate Separation by Selective Crystallization with a Bis-iminoguanidinium Ligand
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2016
A protocol for in situ aqueous synthesis of a bis(iminoguanidinium) ligand and its utilization in selective separation of sulfate is presented.
22:45
Western Blotting Using the Invitrogen NuPage Novex Bis Tris MiniGels
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Cited by 27 •
2007
This technical article describes a standard western-blotting procedure using the commercially available NuPAGE electrophoresis Mini-Gel system from Invitrogen.
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg%3Fv%3D2026-09-01%252007%253A55%253A12&w=750&q=75)
11:44
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
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Cited by 1 •
2014
Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium [(P(NC5H10)3)2Pd(Cl)2] (1) is an easy accessible, cheap, and air stable, but highly active Heck catalyst with an excellent functional group tolerance that efficiently operates under mild reaction conditions to give the coupling products in very high yields.
05:32
In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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2023
Bis-3-chloropiperidines (B-CePs) are useful chemical probes to identify and characterize G-quadruplex structures in DNA templates in vitro. This protocol details the procedure to perform probing reactions with B-CePs and to resolve reaction products by high-resolution polyacrylamide gel electrophoresis.
FAQs
Bis monitoring algorithms evaluate several properties of the recorded electroencephalography signal, including frequency, amplitude, and phase relationships. Combining these signal characteristics produces a bispectral index rather than relying on a single electrical measurement. This processing provides a standardized numerical representation of anesthetic-related brain activity, allowing clinicians to follow changes in hypnotic state during general anesthesia.
The bispectral index provides a numerical scale from 0 to 100, on which lower values generally correspond to deeper hypnosis. Its value lies in tracking the hypnotic component of anesthesia, but clinicians should interpret it together with vital signs and clinical assessment. This combined approach helps place the EEG-derived measurement within the patient’s overall anesthetic condition.
Bis monitoring focuses on the brain’s electrical response associated with hypnosis, whereas vital signs provide broader physiological information. This distinction allows the monitor to contribute information about unconsciousness that is not represented solely by cardiovascular or other clinical observations. Used together, these sources help clinicians assess anesthetic depth more comprehensively and make more informed dosing decisions.
Because it converts processed electroencephalography signals into a standardized index, Bis monitoring offers a consistent framework for comparing brain responses during exposure to anesthetic agents. Researchers can use this framework to examine changes in hypnotic state in a structured way. The resulting measure supports scientific study of anesthesia while retaining a clinically relevant connection to unconsciousness.
The setup uses sensors placed on the patient’s forehead to record electroencephalography activity. The recorded signals are then analyzed by specialized algorithms that generate the index for clinical interpretation. In practice, this creates a noninvasive monitoring stream that can be considered alongside vital signs and clinical assessment while anesthesia is administered.
Clinicians can use the index as an additional guide when adjusting anesthetic administration, helping support adequate unconsciousness without automatically giving more drug than necessary. By contributing information about the hypnotic component, the method may help reduce unnecessary anesthetic administration or delayed recovery. It does not replace clinical assessment, which remains part of interpretation.