Brain Tumor Imaging
Brain Tumor Imaging - Related Videos
09:04
In Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles
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Cited by 13 •
2014
We describe a multi-angle rotational optical imaging (MAROI) system for in vivo quantitation of a fluorescent marker delivered by saposin C (SapC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Employing mouse models of cancer and arthritis, we demonstrate how the MAROI signal curve analysis can be used for the precise mapping and biological characterization of disease processes.
11:09
Establishing Intracranial Brain Tumor Xenografts With Subsequent Analysis of Tumor Growth and Response to Therapy using Bioluminescence Imaging
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Cited by 104 •
2010
Luciferase-modified human brain tumor xenografts can be established intracranially in athymic mice, with subsequent monitoring of tumor growth and response to therapy using bioluminescence imaging. In combination with survival analysis, bioluminescence monitoring is an essential research tool for pre-clinical testing of therapies being considered for treating brain tumors.
02:08
Bioluminescence Imaging to Assess Tumor Growth in an Organotypic Mouse Brain Slice
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2025
Source: Ciraku, L., et. al. An Ex Vivo Brain Slice Model to Study and Target Breast Cancer Brain Metastatic Tumor Growth. J. Vis. Exp. (2021).This video demonstrates the imaging of luciferase-expressing tumor cells in an organotypic mouse brain slice. Luciferin is added to the medium, and the plate is placed inside the chamber of the in vivo imaging system. Parameters for image capture are adjusted, and the tumor's shape and size are defined. The bioluminescent signals emitted by the tumor...
11:02
In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model
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Cited by 16 •
2011
Bioluminescence imaging of hypoxia inducible factor-1α activity is applied to monitor intracranial tumor hypoxia development in a breast cancer brain metastasis mouse model.
12:09
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
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Cited by 14 •
2013
We describe a novel in vivo imaging technique that couples fluorescent chimeric mice with intracranial windows and high-resolution 2-photon microscopy. This imaging platform aids studies of dynamic changes in brain tissue and microvasculature, at a single-cell level, following pathological insults and is adaptable to assess intracranial drug delivery and distribution.
FAQs
MRI provides detailed views of brain tissue using magnetic fields and radiofrequency signals, making it valuable for examining tumor location and surrounding structures. CT uses X-rays and offers a complementary imaging approach. Considering both modalities can help clinicians characterize an abnormality more fully and select imaging information appropriate for diagnosis, treatment planning, or follow-up.
Contrast agents enhance differences between tumor tissue and nearby brain structures, making abnormal areas easier to distinguish on imaging. This added separation can improve assessment of tumor extent and relationships to surrounding anatomy. Clinicians may use the resulting information when evaluating the lesion, planning an intervention, or comparing imaging findings during ongoing care.
PET can add functional or metabolic information about a brain abnormality, complementing the structural detail obtained with MRI or CT. Rather than relying only on appearance, clinicians can consider indications of tumor activity when interpreting the images. This broader view may support characterization, treatment assessment, and evaluation of whether disease appears to be progressing.
Clinicians focus on features such as the tumor's location, size, and effects on surrounding brain structures. These findings help connect imaging observations with practical decisions, including whether and where to obtain a biopsy, how to approach surgery, and how to plan radiation. The same features also establish a basis for later comparisons during treatment.
Imaging localizes the abnormal growth and shows its relationship to surrounding brain tissue, giving clinicians a map for intervention. Those findings can help guide biopsy toward the lesion, support surgical planning, and define radiation treatment plans. Using imaging in this way connects diagnostic assessment with procedures intended to evaluate or treat the tumor.
Clinicians compare images obtained at different points in care to assess whether the tumor and its effects have changed. MRI, CT, or functional and metabolic imaging may contribute, depending on the information needed. These comparisons help evaluate response to treatment and identify imaging evidence that may indicate stable disease, improvement, or progression.
Functional or metabolic imaging may be useful when structural images alone do not provide enough information about tumor activity. PET can add this perspective to the anatomical detail supplied by MRI or CT. Combining these forms of evidence may help clinicians characterize an abnormality more completely and inform decisions about treatment assessment or disease progression.
Imaging findings provide a shared basis for diagnosis and clinical decision-making across different stages of care. By showing location, size, and effects on the brain, scans can inform biopsy, surgery, and radiation planning, then supply reference points for follow-up. This continuity allows imaging to connect initial assessment with treatment evaluation and monitoring over time.