Clinical Toxicology
Clinical Toxicology - Related Videos
11:38
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
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Cited by 24 •
2016
The objective of the study was to assess the biological impact of 15 cigarette smoke constituents using a combination of an impedance-based real time cell analyzer and a high-content screening (HCS)-based platform for toxicological assessment in vitro. This study provides information on effective doses, toxicity and modes of action of the tested compounds.
08:59
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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Cited by 5 •
2020
We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.
07:28
A Toxicological and Ecotoxicological Assay Based on Mussel (Mytilus galloprovincialis) Hemocytes Motility
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2024
The article proposes a novel in vitro method for the rapid and sensitive assessment of the toxicity and ecotoxicity of pollutants, based on the motility of Mytilus galloprovincialis hemocytes. The method aims to contribute to the development of more ethical and sensitive toxicological and ecotoxicological exposure tests.
07:50
Establishment of a Clinic-based Biorepository
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Cited by 4 •
2017
Cutaneous tumors are often discarded following Mohs micrographic surgery. A protocol is described here that enables clinical support staff to effectively process and store cutaneous tumor (e.g., squamous cell carcinoma, basal cell carcinoma, and melanoma) samples for downstream laboratory applications without interfering with clinical operations.
14:37
Accessibility to Clinical Care for People who use Wheelchairs
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2023
Source: Yetsa Tuakli-Wosornu1,2, Jaideep Talwalkar1; 1Yale School of Medicine, 2University of Pittsburgh In the United States, 25% of the general population suffers from one or another type of disability. Ambulatory disabilities, or mobility impairments, represent the most common subcategory, comprising 14% of the country's populace. Different mobility-assistive devices, ranging from canes to scooters, enable increased independence and improved quality of life for those suffering from mobility...
FAQs
Toxicokinetics tracks how a substance is absorbed, distributed, metabolized, and eliminated. This timeline helps clinicians relate an exposure to the substance’s amount and persistence in the body. In practice, these principles support severity assessment and help determine what monitoring or treatment may be appropriate.
Toxicodynamics examines how a substance disrupts biological function after exposure. It complements toxicokinetics by addressing the substance’s effects on the body rather than only its movement through the body. This distinction helps clinicians interpret physical findings and laboratory results while judging the potential seriousness of an exposure.
No single source of information necessarily establishes the clinical picture. Clinicians combine the exposure history with physical findings and laboratory testing to evaluate what happened and how the patient is responding. Interpreting these findings through toxicokinetic and toxicodynamic principles supports a more informed assessment of poisoning severity.
A clinical evaluation generally links recognition of a possible poisoning with assessment of severity, followed by treatment planning and continued observation. Clinicians use the available history, examination findings, and laboratory information to guide decisions about decontamination, antidotes when appropriate, supportive care, and monitoring. The sequence is adapted to the exposure and clinical findings.
Decontamination or antidote selection depends on the clinical assessment rather than occurring automatically after every exposure. Clinicians consider the suspected toxic substance, available findings, and assessed severity when deciding whether either approach is appropriate. Supportive care and monitoring remain important parts of management, including when a specific intervention is not selected.
Clinical toxicology supports several areas of medicine and public health. Its principles inform medication safety, occupational health, emergency practice, and responses to emerging toxic hazards. These applications extend the field beyond individual treatment by helping clinicians and health systems recognize harmful exposures, evaluate their effects, and organize appropriate medical or public health responses.