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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
 

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Article doi: 10.3791/60184
December 3rd, 2020

Summary December 3rd, 2020

We exposed a microphysiological system (MPS) with intestine and liver organoids to acetaminophen (APAP). This article describes the methods for organoid production and APAP pharmacokinetic and toxicological property assessments in the MPS. It also describes the tissue functionality analyses necessary to validate the results.

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