Coronary Balloon Occlusion
Coronary Balloon Occlusion - Related Videos
09:14
The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
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Cited by 16 •
2017
Animal models of atherosclerosis are essential to understand the mechanism and to investigate newer approaches to prevent plaque development or rupture, a leading cause of death in the industrialized world. This protocol uses a combination of balloon injury and cholesterol rich diet to induce atherosclerotic plaques in rabbit iliac artery.
02:06
Inducing Brain Death in a Mouse Model Using a Balloon Catheter
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2025
This video demonstrates the procedure for inducing brain death in a mouse model by increasing controlled intracranial pressure through a balloon catheter, mimicking natural brain death.
06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
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Cited by 20 •
2015
Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.
08:42
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
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Cited by 8 •
2016
The rat carotid balloon injury model described below allows researchers to evaluate drugs or therapeutics that negate injury-induced arterial hyperplasia. Detailed pre-surgical preparation, surgical procedure, and post-surgical cares of the animal are described.
07:36
Isolation of Mouse Coronary Endothelial Cells
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Cited by 18 •
2016
This protocol is prepared to share our method of isolating mouse coronary endothelial cells for the purpose of imaging or to conduct molecular biological experiments.
FAQs
Inflation expands the balloon until it apposes the arterial wall, creating a temporary interruption in blood flow through the selected coronary segment. The resulting change in perfusion provides a controlled period for observing cardiovascular responses or supporting an intervention. Deflation removes the obstruction and restores flow, allowing clinicians to compare conditions before, during, and after occlusion.
The physiological effect depends on which vessel segment is blocked and how long perfusion is interrupted. A selected location determines the myocardial territory affected, while duration influences the degree of ischemic stress. For that reason, clinicians must control both variables and monitor the patient closely rather than treating balloon inflation as an isolated mechanical step.
Temporary interruption of coronary flow can expose physiological information about myocardial ischemia and collateral circulation. The response may also include clinically important rhythm disturbances or signs of ischemic injury. Observing these effects under controlled conditions helps clinicians and researchers assess how the heart responds when perfusion changes in a defined vessel segment.
The defining procedural distinction is reversibility. A balloon produces a short-term obstruction that can be ended by deflation, whereas the overview describes no permanent closure of the vessel. This temporary design allows controlled assessment or procedural support while permitting restoration of flow. The reversible interval is also why timing and physiological monitoring remain central to its use.
A balloon-mounted catheter is positioned in the intended coronary artery or selected vessel segment under imaging guidance. The balloon is then inflated to appose the arterial wall and create the planned interruption of perfusion. After the assessment or treatment step is complete, clinicians deflate the balloon to restore flow while monitoring for ischemic effects or rhythm disturbances.
Supported uses include evaluating myocardial ischemia, assessing collateral circulation, controlling bleeding in selected situations, and supporting other interventional cardiovascular procedures. The appropriate role depends on the target vessel and procedural objective. Because the technique changes coronary perfusion, its use requires a controlled setting in which the occlusion and the resulting physiological effects can be observed.
Researchers can examine how myocardial perfusion changes when flow through a defined vessel segment is interrupted and then restored. The response may provide information about ischemia, collateral circulation, and associated rhythm changes. This makes the technique useful for studying cardiovascular physiology as well as for evaluating responses during selected cardiovascular procedures.
Monitoring should focus on the effects of interrupted perfusion, including evidence of myocardial ischemic injury and rhythm disturbances. Clinicians also need to track the planned duration and location of the occlusion and confirm restoration of flow after deflation. These observations help maintain control of the procedure and identify adverse cardiovascular responses promptly.