Journal
/
Medicine
/
Intravascular Delivery of Biologics to the Rat Kidney
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

DOI:
10.3791/54418-v

•

07:29 min

•

September 01, 2016

•

, , , ,
1Divisions of Cardiovascular Diseases, Department of Internal Medicine,Mayo Clinic, 2Divisions of Nephrology and Hypertension, Department of Internal Medicine,Mayo Clinic

Chapters

  • 00:05Title
  • 00:57Surgical Preparation
  • 01:57Surgical Procedure
  • 05:36Results: Intravascular Delivery of Rat Recombinant VEGF into the Rat Kidney
  • 06:41Conclusion

Summary

Automatic Translation

Automatic Translation

The administration of drugs for recovery of kidney function requires control of the localization and distribution of the therapeutic compound. Here, we describe in detail a simple technique for intrarenal delivery of drugs in rats. This procedure may be easily performed with no mortality and high reproducibility.

Tags

Keywords: Intravascular DeliveryBiologicsRat KidneyRenal ArteryLocalized Therapeutic EffectRenal Microvascular CompartmentRenal PathologiesRenal Microvascular FunctionKidney DiseasesKidney DamageSurgeryAnesthesiaLaparotomyAortaRenal ArteryMicrovascular ClipsIntravenous Catheter

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/54418?article_type=v

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
check_url/54418?article_type=v

Mouse Kidney Transplantation: Models of Allograft Rejection
check_url/54418?article_type=v

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
check_url/54418?article_type=v

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
check_url/54418?article_type=v

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
check_url/54418?article_type=v

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
check_url/54418?article_type=v

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
check_url/54418?article_type=v

Intratracheal Administration of Dry Powder Formulation in Mice
check_url/54418?article_type=v

Direct Drug Delivery to Kidney via the Renal Artery
check_url/54418?article_type=v

A Rat Lung Transplantation Model of Warm Ischemia/Reperfusion Injury: Optimizations to Improve Outcomes

Read Article