Isometric Force Measurement

Isometric force measurement is the quantification of force produced during a contraction in which a muscle generates tension without appreciable change in muscle length or joint angle. The technique typically uses a dynamometer, force transducer, or load cell to record the mechanical output of a sustained contraction under controlled conditions. In medicine, clinicians and researchers use these measurements to assess muscle strength, identify neuromuscular impairment, monitor rehabilitation, and evaluate changes associated with injury or disease. Standardized testing can provide objective, repeatable outcomes for tracking treatment response, comparing limbs, and studying how muscle function relates to mobility and physical performance.

Isometric Force Measurement - Related Videos

Research

JoVE Journal - Bioengineering
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Measurement of Maximum Isometric Force Generated by Permeabilized Skeletal Muscle Fibers

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Cited by 49 •

2015

Analysis of the contractile properties of chemically skinned, or permeabilized, skeletal muscle fibers offers a powerful means by which to assess muscle function at the level of the single muscle cell. In this article we outline a valid and reliable technique to prepare and test permeabilized skeletal muscle fibers in vitro.

Research

JoVE Journal - Biology
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Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies

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Cited by 85 •

2013

Muscle function measurements contribute to the evaluation of potential therapeutics for muscle pathology, as well as to the determination of mechanisms underlying physiology of this tissue. We will demonstrate the preparation of the extensor digitorum longus and diaphragm muscles for functional testing. Protocols for isometric and eccentric contractions will be shown, as well as differences in results between dystrophic muscles, representing a pathological state, and wildtype muscles.

Research

JoVE Journal - Neuroscience

Maximum Isometric Tetanic Force Measurement of the Tibialis Anterior Muscle in the Rat

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Cited by 3 •

2021

Evaluation of motor recovery remains the benchmark outcome measure in experimental peripheral nerve studies. The isometric tetanic force measurement of the tibialis anterior muscle in the rat is an invaluable tool to assess functional outcomes after reconstruction of sciatic nerve defects. The methods and nuances are detailed in this article.

Research

JoVE Journal - Biology
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In Vivo Measurement of Hindlimb Dorsiflexor Isometric Torque from Pig

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Cited by 6 •

2021

The present protocol describes concise experimental details on the evaluation and interpretation of in vivo torque data obtained via electrical stimulation of the common peroneal nerve in anesthetized pigs.

Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography

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Cited by 16 •

2018

The wire myograph technique is used to investigate vascular smooth muscle functions and screen new drugs. We report a detailed protocol for measuring the isometric contractility of the mouse mesenteric artery and for screening new relaxants of vascular smooth muscle.

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