The wire myograph technique is used to investigate vascular smooth muscle functions and screen new drugs. We report a detailed protocol for measuring the isometric contractility of the mouse mesenteric artery and for screening new relaxants of vascular smooth muscle.
Sun, J., Yang, G. M., Tao, T., Wei, L. S., Pan, Y., Zhu, M. S. Isometric Contractility Measurement of the Mouse Mesenteric Artery Using Wire Myography. J. Vis. Exp. (138), e58064, doi:10.3791/58064 (2018).