Late Gadolinium Enhancement
Late Gadolinium Enhancement - Related Videos
05:15
An Aptamer-based Sensor for Unchelated Gadolinium(III)
0 Views •
2017
The use of polydeoxynucleotide (44-mer aptamer) molecules for sensing unchelated gadolinium(III) ion in an aqueous solution is described. The presence of the ion is detected via an increase in the fluorescence emission of the sensor.
08:44
The Utility of Stage-specific Mid-to-late Drosophila Follicle Isolation
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Cited by 12 •
2013
Stage-specific isolation of mid-to-late Drosophila follicles is useful for a variety of purposes. Such follicles develop in culture, which allows for genetic and/or pharmacologic manipulations to be coupled with in vitro development assays and live imaging. Additionally, follicles can be used for molecular studies, such as isolating mRNA and protein.
08:15
Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice
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Cited by 18 •
2012
Measuring left ventricular pressure (LV) in embryonic and neonatal mice is described. Pressure is measured by inserting a needle connected to a fluid-filled transducer into the LV under ultrasound guidance. Care must be taken to maintain normal cardiac function during the experimental protocol.
15:12
Primary Neuronal Cultures from the Brains of Late Stage Drosophila Pupae
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Cited by 19 •
2007
This video demonstrates the preparation of primary neuronal cultures from the brains of late stage Drosophila pupae. Views of live cultures show neurite outgrowth and imaging of calcium levels using Fura-2.
07:59
Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis
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Cited by 3 •
2016
This manuscript describes the use of a bioluminescent strain of African trypanosomes to enable the tracking of late stage infection and demonstrates how in vivo live imaging can be used to visualize infections within the central nervous system in real-time.
FAQs
The key signal difference comes from extracellular-space expansion. Injured, scarred, or fibrotic myocardium can retain gadolinium after normal myocardium has cleared it, producing higher signal in delayed images. This contrast allows the scan to depict tissue abnormalities rather than merely showing cardiac anatomy, making extracellular retention central to interpretation.
Timing and signal preparation are essential to the contrast pattern. Images are obtained several minutes after intravenous gadolinium, when normal myocardium has largely cleared the agent. An inversion-recovery sequence then suppresses signal from healthy myocardium, so regions with persistent contrast appear conspicuous. Together, these steps create the separation between normal and abnormal tissue.
It can reveal myocardial injury, scar, fibrosis, inflammation, or replacement fibrosis. These findings represent tissue abnormalities associated with expanded extracellular space and can occur in infarction, cardiomyopathy, or myocarditis. The technique therefore links image signal with tissue characterization, making it useful for recognizing the nature of myocardial abnormality in clinical imaging.
A typical examination starts with intravenous gadolinium administration, followed by a wait of several minutes. MRI images are then acquired with an inversion-recovery sequence. The sequence suppresses signal from healthy myocardium, while areas that retain contrast remain brighter. This workflow creates the delayed tissue-contrast pattern used for cardiac assessment.
In cardiovascular medicine, the method is useful for identifying myocardial infarction and distinguishing ischemic from nonischemic cardiomyopathy. It also helps detect inflammation or replacement fibrosis in conditions such as myocarditis. These applications extend beyond locating an abnormal signal: they support diagnostic evaluation of different forms of structural heart disease.
Findings from the scan support diagnosis, risk assessment, treatment planning, and monitoring of structural heart disease. By showing myocardial injury, scar, fibrosis, or inflammation, the images provide tissue-level information that can complement clinical assessment. Their value therefore includes both initial characterization and follow-up of disease.