Lung Parenchyma
Lung Parenchyma - Related Videos
11:10
Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
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Cited by 127 •
2011
The stiffness of the extracellular matrix strongly influences multiple behaviors of adherent cells. Matrix stiffness varies spatially throughout a tissue, and undergoes modification in various disease conditions. Here we develop methods to characterize spatial variations in stiffness in normal and fibrotic mouse lung tissue using atomic force microscopy microindentation.
07:27
Robotic-assisted Left Pneumonectomy For Vanishing Lung Syndrome
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2026
Robotic-assisted pneumonectomy is safe and effective in the management of Vanishing Lung Syndrome, with reduced morbidity and faster recovery times.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
09:49
Measurement of the Pressure-volume Curve in Mouse Lungs
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Cited by 47 •
2015
Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.
01:47
Lung Capacity
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2019
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures. There are four defined lung volume measures: tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume. Tidal volume is the amount of air inhaled and exhaled in a normal breath. Inspiratory...
FAQs
Gas movement depends on differences in partial pressure between alveolar air and the blood reaching the lungs. Oxygen diffuses across the thin alveolar-capillary membrane into the blood, while carbon dioxide moves in the opposite direction for removal. The membrane’s thin structure supports efficient exchange, making disruption of this interface important when evaluating respiratory impairment.
Conducting airways deliver inhaled air to the alveoli, positioning oxygen and carbon dioxide exchange where it can occur. Pulmonary blood flow then carries blood to this exchange region, enabling oxygen uptake and carbon dioxide removal. Effective respiratory function therefore depends on coordination between air delivery, the alveolar-capillary interface, and circulation through the lungs.
The alveolar-capillary membrane forms the thin interface through which respiratory gases diffuse. Its location between alveolar air and pulmonary blood makes it central to oxygen entry and carbon dioxide elimination. Clinical assessment of lung parenchyma helps identify conditions that may affect this functional region, including pulmonary fibrosis and interstitial lung disease, and supports evaluation of resulting respiratory impairment.
Clinicians assess the tissue through complementary approaches that include imaging, pulmonary function testing, and histopathology. Imaging helps examine parenchymal abnormalities, pulmonary function testing evaluates respiratory performance, and histopathology examines tissue changes. Together, these methods can support identification of pneumonia, pulmonary fibrosis, emphysema, and interstitial lung disease rather than relying on a single type of evidence.
Imaging is one method for examining the lung parenchyma during evaluation of respiratory disease. It can contribute to identifying abnormalities associated with conditions such as pneumonia, pulmonary fibrosis, emphysema, and interstitial lung disease. In clinical decision-making, those findings are considered alongside pulmonary function results and, when relevant, histopathology to support diagnosis and treatment planning.
Pulmonary function testing and histopathology provide different but complementary information. Function testing evaluates how respiratory impairment affects lung performance, whereas histopathology examines tissue directly. Using these approaches with imaging can strengthen assessment of parenchymal disease and help clinicians identify the nature of conditions such as fibrosis, emphysema, pneumonia, or interstitial lung disease for treatment planning and follow-up.