Peri-neuronal Injection
Peri-neuronal Injection - Related Videos
08:28
Zebrafish Brain Ventricle Injection
0 Views •
Cited by 72 •
2009
After neural tube formation, the neuroepithelium constricts and folds while the tube fills with embryonic cerebrospinal fluid (eCSF) to form the embryonic brain ventricles. We developed this ventricle injection technique to better visualize the fluid filled space in contrast to the neuroepithelial shape in a live embryo.
03:45
Intraductal Injection: Delivering Injection Mix into the Ducts of the Mouse Mammary Gland
0 Views •
2023
This video describes an intraductal injection technique where we deliver injection mix into the ducts of mouse mammary glands.
03:48
Mouse Bladder Wall Injection
0 Views •
Cited by 34 •
2011
Mouse bladder wall injection is a useful approach to orthotopically study bladder stem cell and cancer biology. This delicate microsurgical method can be mastered with careful technique and practice.
10:28
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
0 Views •
Cited by 21 •
2015
Supramolecular hydrogelators based on ureido-pyrimidinones allow full control over the macroscopic gel properties and the sol–gel switching behavior using pH. Here, we present a protocol for formulating and injecting such a supramolecular hydrogelator via a catheter delivery system for local delivery directly in relevant areas in the pig heart.
09:19
Intraperitoneal Injection into Adult Zebrafish
0 Views •
Cited by 238 •
2010
We demonstrate intraperitoneal injection into adult zebrafish. We use a 10 μl NanoFil microsyringe controlled by a Micro4 controller and UltraMicroPump III. This demonstration includes the use of cold water as an anesthetic.
FAQs
The substance diffuses through connective tissues surrounding the peripheral nerve and reaches nearby nerve fibers without being placed directly inside the nerve. When the solution contains a local anesthetic, it reduces nerve-signal transmission in that region. The resulting effect depends on the substance selected and supports either temporary sensory control or a targeted therapeutic response.
Surrounding connective tissues provide the pathway through which the injected solution spreads around the nerve. This local distribution allows the substance to influence nearby fibers while keeping treatment concentrated near the intended anatomical target. The tissue environment therefore helps connect the injection site with the desired regional effect, including reduced signaling or modification of local inflammation.
The injected substance determines the primary biological effect. A local anesthetic is used when reducing nerve-signal transmission is the goal, whereas another therapeutic agent may be selected to modify local inflammation. Diagnostic substances serve a different purpose by helping assess nerve-related symptoms. Matching the substance to the clinical objective makes the injection more informative or therapeutically focused.
At a high level, clinicians identify the relevant peripheral nerve, place the therapeutic or diagnostic substance around it rather than directly into it, and assess the resulting regional response. The solution then diffuses through nearby connective tissues. This workflow links the anatomical target with an observable change in nerve-related symptoms or function, depending on the substance used.
Clinicians may use this approach for regional anesthesia, targeted pain management, or selected nerve-related diagnostic procedures. It is particularly relevant when treatment needs to be concentrated near an affected nerve instead of distributed broadly. By producing a localized effect, the technique can help control symptoms and, in diagnostic settings, contribute to decisions about further medical or surgical care.
A response after treatment near the affected nerve can provide clinically useful information about the nerve's contribution to symptoms. In therapeutic settings, symptom reduction supports targeted regional control. In diagnostic settings, the observed effect may help clinicians evaluate nerve-related problems and decide whether additional medical management or surgical care should be considered.