Ventricular Myocardium
Ventricular Myocardium - Related Videos
11:33
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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Cited by 15 •
2013
Kv channel dysfunction is associated with cardiac arrhythmias. In order to study the molecular mechanisms that lead to such arrhythmias we utilize a systematic protocol for isolation of atrial and ventricular cardiomyocytes from Kv channel ancillary subunit knockout mice. Isolated cardiomyocytes can then immediately be used for cellular electrophysiological studies, biochemical or immunofluorescence (IF) assays.
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Cited by 34 •
2013
This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.
12:09
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
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Cited by 14 •
2013
A methodology to estimate ventricular fiber orientations from in vivo images of patient heart geometries for personalized modeling is described. Validation of the methodology performed using normal and failing canine hearts demonstrate that that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.
09:05
Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Cited by 9 •
2016
Speckle tracking echocardiography is an emerging diagnostic imaging technique for the quantitative assessment of global and regional myocardial performance. Standard view echocardiographic motion images are recorded and deformation parameters are subsequently measured by automated continuous frame-by-frame tracking and motion analysis of speckles within the B-mode images of the myocardium.
14:39
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
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Cited by 44 •
2014
Current knowledge on the cellular basis of cardiac diseases mostly relies on studies on animal models. Here we describe and validate a novel method to obtain single viable cardiomyocytes from small surgical samples of human ventricular myocardium. Human ventricular myocytes can be used for electrophysiological studies and drug testing.
FAQs
An action potential activates L-type calcium channels in ventricular cardiomyocytes. The resulting calcium entry triggers additional calcium release from the sarcoplasmic reticulum, increasing the calcium available to the contractile apparatus. This sequence links electrical excitation to sarcomere shortening, allowing ventricular muscle cells to generate the force required for effective cardiac pumping.
Electrical conduction organizes when ventricular cardiomyocytes are activated, while relaxation determines how the tissue returns to its resting state. Their coordination supports an effective cycle of contraction and recovery. Disruption in either process can affect stroke volume or rhythm, making these properties important when examining ventricular performance and cardiac electrical behavior.
Pathological remodeling changes the ventricular myocardium in ways that can compromise contractility or disturb rhythm. Its clinical relevance is reflected in conditions such as heart failure, cardiomyopathies, and arrhythmias. Studying remodeling helps connect altered myocardial structure or function with impaired pumping and supports the development of therapies intended to preserve contractility or limit further change.
Evaluation can draw on electrocardiography and cardiac imaging, with electrophysiology providing additional information about the heart’s electrical behavior. These approaches help assess features related to ventricular contraction, conduction, relaxation, and rhythm. Together, they support clinical investigation of myocardial infarction, heart failure, cardiomyopathies, and arrhythmias rather than relying on a single type of measurement.
Electrocardiography examines the electrical activity associated with the heart and therefore helps investigate conduction and rhythm in the ventricular myocardium. Because electrical activation precedes calcium-dependent contraction, electrocardiographic findings provide an important functional context for understanding ventricular performance. The method is especially relevant when arrhythmias or other abnormalities of cardiac electrical behavior are being evaluated.
Cardiac imaging and electrophysiology address complementary aspects of ventricular function. Imaging contributes to assessment of the myocardium and its pumping behavior, whereas electrophysiology focuses on electrical conduction and rhythm. Considering these findings with calcium-dependent contractility can support evaluation of disease and guide therapies designed to preserve ventricular performance or limit pathological remodeling.