Hdl-mimicking Nanoparticles
Hdl-mimicking Nanoparticles - Related Videos
08:24
Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation
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Cited by 4 •
2017
Simple homogenization was used to prepare novel, high-density, lipoprotein-mimicking nanoparticles to encapsulate nerve growth factor. Challenges, detailed protocols for nanoparticle preparation, in vitro characterization, and in vivo studies are described in this article.
03:06
Encapsulating Nerve Growth Factor in High-Density Lipoprotein-Mimicking Nanoparticles
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2025
Source: Zhu, J., et. al., Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation. J. Vis. Exp. (2017)This video demonstrates the stepwise assembly of NGF-loaded HDL-mimicking nanoparticles using protamine-assisted encapsulation and lipid-based self-assembly for potential neurotrophic delivery applications.
09:23
Harmonic Nanoparticles for Regenerative Research
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Cited by 1 •
2014
Protocol details are provided for in vitro labeling human embryonic stem cells with second harmonic generating nanoparticles. Methodologies for hESC investigation by multi-photon microscopy and their differentiation into cardiac clusters are also presented.
06:42
Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
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2025
This article presents the protocol for preparing tumor-tissue phantoms that replicate optical properties for plasmonic photothermal therapy. It details phantom preparation, photothermal evaluations, and validation of the developed numerical model based on photothermal temperature measurements for assessing therapeutic parameters, offering an ethical, cost-effective alternative to in vivo studies for preliminary testing.
13:39
Optical Trapping of Nanoparticles
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Cited by 7 •
2013
The following setup approach details low power optical trapping of dielectric nanoparticles using a double-nanohole in metal film.
FAQs
These components can help the particles interact with lipoprotein receptors, providing a biological recognition mechanism beyond passive delivery. Receptor engagement may influence which cells internalize the nanocarriers and how efficiently they take up the associated cargo. In neuroscience research, this feature is relevant because selective cellular interactions could improve delivery precision in tissues affected by neurological disease.
Particle size and surface composition can affect how nanocarriers move across biological barriers, including barriers relevant to the brain. These properties may influence access to neural tissue, interactions with surrounding biological components, and cellular uptake. Consequently, researchers must consider both variables when evaluating whether a formulation can reach its intended site and retain useful delivery behavior.
Their lipid-based surfaces provide a compatible environment for encapsulating hydrophobic drugs, which have limited compatibility with aqueous biological surroundings. Encapsulation can help stabilize the cargo during transport, while receptor interactions and cellular uptake may support delivery to target cells. This combination links cargo formulation with biological targeting and may improve therapeutic precision.
The approach combines engineered cargo transport with features inspired by a natural lipid-transport system. Its apolipoprotein-inspired components and lipid surface may support receptor interactions, while the particle architecture accommodates hydrophobic cargo. This offers a mechanism for integrating stability, cellular uptake, and biological recognition rather than treating drug protection and tissue interaction as separate design problems.
Development focuses on how lipid-based surfaces, apolipoprotein-inspired components, particle size, and surface composition work together. Researchers can evaluate whether the formulation encapsulates hydrophobic cargo, maintains cargo stability, interacts with relevant receptors, and supports cellular uptake. These properties provide a practical basis for comparing formulations intended for brain delivery, imaging, or lipid-associated therapeutic studies.
They may investigate them when a study requires brain-targeted delivery, imaging, or modulation of lipid-associated processes. The platform is particularly relevant to research on neuroinflammation and neurodegenerative disease, where lipid handling and cellular responses can influence disease-related biology. Its potential value lies in connecting delivery performance with mechanisms studied in affected neural tissues.
The particles can serve as carriers for therapeutic cargo or imaging-related applications while also engaging lipid-associated biological pathways. In studies of neuroinflammation or neurodegenerative disease, researchers can examine whether their composition supports access to relevant tissue, cellular uptake, and more precise modulation of disease-related processes. These investigations connect nanocarrier design with neurological mechanisms involving lipids.
Relevant outcomes include successful encapsulation of hydrophobic cargo, preservation of cargo stability, interaction with lipoprotein receptors, and effective cellular uptake. For neuroscience applications, researchers may also assess whether particle size and surface composition support movement toward brain tissue or improve imaging and therapeutic precision. Together, these measurements show whether biomimetic design produces the intended biological delivery advantages.