Thecal Sac Access
Thecal Sac Access - Related Videos
10:38
Isolation of Early Hematopoietic Stem Cells from Murine Yolk Sac and AGM
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Cited by 19 •
2008
This video shows how to micro-dissect the yolk sac and aorta-gonad-mesonephros region from embryos and use flow cytometry to sort hematopoietic stem cells.
04:34
Surgical Treatment of an Endolymphatic Sac Tumor
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Cited by 1 •
2023
Here, we discuss clinical and radiological features of endolymphatic sac tumors and report the methodology and results of a surgical removal in a case in care at our otologic referral center.
11:53
Primary Endodermal Epithelial Cell Culture from the Yolk Sac Membrane of Japanese Quail Embryos
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Cited by 6 •
2016
To study the mechanism of lipid utilization in yolk sac membranes during the late stages of avian embryonic development, we established a primary Japanese quail embryonic endodermal epithelial cell culture system.
04:34
Dissection of the Endolymphatic Sac from Mice
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Cited by 5 •
2021
This study describes how to dissect the endolymphatic sac from the inner ear of the mouse at different ages. The result of a similar dissection is shown in an Slc26a4-null mouse model of enlargement of the endolymphatic sac. A transgenic mouse with a fluorescent reporter expressed in the endolymphatic sac is presented as a model to readily visualize the endolymphatic sac, and educational tool.
14:37
Accessibility to Clinical Care for People who use Wheelchairs
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2023
Source: Yetsa Tuakli-Wosornu1,2, Jaideep Talwalkar1; 1Yale School of Medicine, 2University of Pittsburgh In the United States, 25% of the general population suffers from one or another type of disability. Ambulatory disabilities, or mobility impairments, represent the most common subcategory, comprising 14% of the country's populace. Different mobility-assistive devices, ranging from canes to scooters, enable increased independence and improved quality of life for those suffering from mobility...
FAQs
Entry into the subarachnoid compartment matters because this space contains cerebrospinal fluid and lies within the dural sac around the spinal cord and nerve roots. When fluid is encountered, it provides procedural confirmation that the needle has reached the intended compartment. That confirmation supports either dependable sampling or placement of an intrathecal substance.
Accurate localization of a lumbar intervertebral space helps direct the needle toward the intended access point, while sterile technique and careful monitoring help reduce complications. Together, these controls improve procedural reliability, support the intended access, and help ensure that collected fluid or administered material reflects the planned intervention.
The same route can support two different objectives. For assessment, cerebrospinal fluid is collected for evaluation or biomarker measurement. For treatment or experimental delivery, a substance is placed intrathecally, meaning into the spinal fluid compartment. Separating these objectives clarifies whether the procedure is designed to obtain information, deliver therapy, or do both.
After anatomical localization, the needle is advanced through a lumbar intervertebral space toward the subarachnoid compartment. Encountering cerebrospinal fluid indicates access, after which the operator can collect the sample or administer the intended substance intrathecally. Sterile technique and monitoring accompany these steps, helping maintain procedural reliability and reduce complications.
Samples obtained through this route can be examined for cerebrospinal fluid biomarkers and can contribute to evaluation of neurological or infectious conditions. The value of the sample depends on reaching the intended compartment and obtaining fluid that corresponds to the planned access. In neuroscience, this connects a physical procedure with biomarker-based evaluation.
Researchers and clinicians may use this approach when information from cerebrospinal fluid is needed or when a substance must be delivered directly into the central nervous system. Its applications therefore span diagnostic evaluation, biomarker measurement, infectious-condition assessment, and targeted therapeutic delivery. The objective determines whether fluid collection, intrathecal administration, or both are performed.