Tumor Tissue Dissection
Tumor Tissue Dissection - Related Videos
06:44
Automated Dissection Protocol for Tumor Enrichment in Low Tumor Content Tissues
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Cited by 2 •
2021
Digital annotation with automated tissue dissection provides an innovative approach to enriching tumor in low tumor content cases and is adaptable to both paraffin and frozen tissue types. The described workflow improves accuracy, reproducibility and throughput and could be applied to both research and clinical settings.
11:12
Tissue Engineering of a Human 3D in vitro Tumor Test System
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Cited by 34 •
2013
Methods to create human 3D tumor tissues as test systems are described. These technologies are based on a decellularized Biological Vascularized Scaffold (BioVaSc), primary human cells and a tumor cell line, which can be cultured under static as well as under dynamic conditions in a flow bioreactor.
02:31
FFPE Tumor Tissue Macrodissection: A Technique to Obtain Specific Tumorous Tissue from Unstained Specimens
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2023
This video describes a method for the manual macrodissection of cancer tissue from unstained tissue specimens to obtain a specific cancer tissue. The tissue section can be processed further to obtain DNA for genome-wide studies on gastrointestinal cancers.
10:43
Dissection of Larval Zebrafish Gonadal Tissue
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Cited by 6 •
2017
Here, we present a protocol for isolating gonadal tissue of larval zebrafish, which will facilitate investigations of zebrafish sex differentiation and maintenance.
04:09
The Pocket-Creation Procedure of Endoscopic Submucosal Dissection for Large Rectal Laterally Spreading Tumors
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Cited by 1 •
2026
This study details a standardized PCM-ESD protocol for resecting large rectal LSTs, aiming to enhance dissection speed and prevent transmural perforation via submucosal tunneling.
FAQs
Reliable analysis depends on distinguishing tumor from adjacent normal tissue before removing a defined region. Preserving that boundary reduces unintended inclusion of neighboring cells, which could alter measurements of cellular composition, organization, or molecular features. This precision is especially important when dissected brain tumors are compared directly with nearby tissue.
Paired samples allow investigators to examine differences between tumor tissue and nearby brain tissue within the same biological setting. Histological and cellular analyses can reveal changes in composition and organization, while molecular studies can identify disease-associated differences. These comparisons help clarify how tumors interact with surrounding nervous-system structures.
Instruments enable controlled removal of selected tissue regions while limiting disruption of adjacent structures. Their use must match the need for anatomical precision and sample isolation, because poorly defined removal can increase contamination and reduce interpretability. The resulting region-specific specimens are better suited to downstream cellular, anatomical, or molecular examination.
The process begins by identifying the tumor and its boundaries relative to surrounding structures, followed by precise separation and isolation of the selected region. Researchers then preserve the defined sample for an appropriate analysis, such as histology, molecular profiling, or cell culture. Clear region selection connects the dissection step to the intended experimental outcome.
Dissected specimens can be analyzed to assess disease-associated features and treatment-related changes in tumor tissue or neighboring regions. Molecular profiling may identify altered molecular characteristics, while histology and cellular analysis can show changes in organization or composition. Comparing defined samples supports interpretation of how tumors respond within their surrounding biological environment.
In neuroscience, isolating brain tumor regions together with neighboring tissue creates material for studying interactions between tumors and the nervous system. Samples can support histology, molecular profiling, and cell culture, allowing researchers to examine structure, cellular composition, and disease-associated changes. These complementary analyses provide different perspectives on tumor biology and its local context.