Gd-dtpa
Gd-dtpa - Related Videos
11:22
Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
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Cited by 2 •
2016
A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.
16:24
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
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Cited by 13 •
2012
The goal of this experiment is to determine and control the size, shape and stability of self-assembled discotic amphiphiles in water. For aqueous based supramolecular polymers such level of control is very difficult. We apply a strategy using both repulsive and attractive interactions. The experimental techniques applied to characterize this system are broadly applicable.
09:29
The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
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Cited by 81 •
2015
Due to its multi-day radioactive half-life and favorable decay properties, the positron-emitting radiometal 89Zr is extremely well-suited for use in antibody-based radiopharmaceuticals for PET imaging. In this protocol, the bioconjugation, radiosynthesis, and preclinical application of 89Zr-labeled antibodies will be described.
06:15
Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
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Cited by 15 •
2014
A novel methodology that is employed for the treatment of recurrent glioblastomas is described. This treatment approach employs the application of alternating electric tumor treating fields (TTFields), known as TTF Therapy in combination with bevacizumab, a targeted agent that is currently FDA approved as monotherapy.
07:46
Use of Artificial Sputum Medium to Test Antibiotic Efficacy Against Pseudomonas aeruginosa in Conditions More Relevant to the Cystic Fibrosis Lung
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Cited by 159 •
2012
Current diagnostic antimicrobial susceptibility testing relies on the planktonic growth of isolates in nutrient rich, aerobic conditions. Here, we employ an alternative artificial sputum medium to study antimicrobial susceptibility of Pseudomonas aeruginosa biofilms under both aerobic and microaerophilic conditions more representative of the cystic fibrosis lung.
FAQs
The gadolinium ion changes the relaxation behavior of nearby hydrogen nuclei, primarily shortening their T1 relaxation times. Hydrogen nuclei then return toward their equilibrium state more rapidly, increasing signal intensity in T1-weighted images. This mechanism allows regions containing the contrast agent to appear more conspicuous, helping distinguish physiological structures that may otherwise have limited visibility.
DTPA binds the gadolinium ion and helps maintain it as a soluble, biologically usable complex. This chelation is important because the imaging effect depends on the gadolinium-containing complex being present in the biological environment while remaining suitable for MRI use. Consequently, the ligand supports the agent’s function as a contrast medium rather than serving as the primary source of signal change.
The locations reached by Gd-DTPA influence which structures show increased visibility on T1-weighted images. Its distribution can provide information related to vascular structures, tissue perfusion, and permeability, so enhancement patterns can reflect more than anatomy alone. In bioengineering studies, this relationship helps connect MRI signal changes with how fluids or contrast agents move through tissues and engineered systems.
T1 shortening converts the presence and local distribution of the contrast agent into increased signal on T1-weighted MRI. That signal change can make vascular or tissue-related features easier to identify and can support assessment of physiological behavior alongside structure. The same principle is useful for engineered biomaterials when researchers need imaging information about their interaction with surrounding biological environments.
A study uses Gd-DTPA together with MRI acquisition that includes T1-weighted imaging, allowing signal changes associated with the agent to be visualized. Researchers can then examine the resulting images for vascular structures, perfusion, permeability, or biomaterial-related features. This workflow links a noninvasive imaging readout with structural and functional questions without requiring surgical sampling.
Changes in the visibility and distribution of the contrast agent can help researchers evaluate how tissues are perfused and how readily the agent is associated with tissue regions. These measurements provide functional context that complements anatomical imaging. In bioengineering, such information can help characterize tissue behavior or assess how engineered constructs relate to transport through their surrounding biological environment.
Gd-DTPA enables MRI-based evaluation of engineered biomaterials while preserving the noninvasive character of the study. Because the agent alters local MRI signal, researchers can investigate biomaterial-associated structure and function using image data rather than relying exclusively on surgical sampling. This supports assessment of how an engineered material appears within, or relates to, biological tissues and physiological processes.