Volume Overload

Volume overload is a clinical condition in which excess fluid accumulates in the body, often within the intravascular space and tissues, disrupting normal physiology and potentially impairing organ function. It develops when fluid intake or retention exceeds the body’s ability to excrete water and sodium, increasing hydrostatic pressure and driving fluid into the interstitial space; common contributors include heart, kidney, or liver dysfunction. Clinicians evaluate weight changes, edema, jugular venous pressure, blood pressure, urine output, and respiratory findings to identify severity and guide treatment, which may include fluid and sodium restriction, diuretics, or management of the underlying disease. Recognizing volume overload supports timely intervention, reduces complications such as pulmonary edema, and helps monitor response across acute and chronic care.

Volume Overload - Related Videos

Research

JoVE Journal - Medicine

Adult and Pediatric Porcine Model of Acute Volume Overload

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2024

The protocol here shows how continuous administration of crystalloids into the central veins of a euvolemic pig/piglet allows for the appropriate investigation of the physiological effects of acute volume overload.

Establishment and Confirmation of a Postnatal Right Ventricular Volume Overload Mouse Model

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Cited by 6 •

2023

This protocol presents the establishment and confirmation of a postnatal right ventricular volume overload (VO) model in mice with abdominal arteriovenous fistula (AVF), which can be applied to investigate how VO contributes to postnatal heart development.

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

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Cited by 3 •

2022

This protocol presents a practical guide on the surgery for creation of aortic regurgitation (AR) in the mouse. Assessment of the AR mouse by echocardiography and invasive hemodynamic measurement recapitulates its clinically relevant characteristics of volume overload-induced eccentric hypertrophy, suggesting its promising application in the study of cardiac hypertrophy.

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

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Cited by 6 •

2020

A rodent model of left heart volume overload from mitral regurgitation is reported. Mitral regurgitation of controlled severity is induced by advancing a needle of defined dimensions into the anterior leaflet of the mitral valve, in a beating heart, with ultrasound...

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

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Cited by 4 •

2017

We have outlined a method of continuous manual exchange transfusion for the treatment of sickle cell disease in patients. This safe protocol was designed to effectively limit iron overload in patients in need of chronic transfusions and can be used extensively without any special equipment.

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