Aortic Graft
Aortic Graft - Related Videos
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
07:37
Mouse Models for Graft Arteriosclerosis
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Cited by 16 •
2013
We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
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Cited by 4 •
2013
Histological and biochemical modifications after aneurysm endograft exclusion are still unclear. We describe a new model of endograft implantation on a murine aneurysm. Through thrombus analysis with and without persistant circulating blood stream interface, and new endovascular biomaterials evaluation, this model will help to better understand endovascular aneurysm exclusion pathobiology.
09:12
Aortic Ring Assay
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Cited by 47 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
05:40
A Mouse Aortic Interposition Model to Study Alloimmune-Induced Vascular Rejection
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2025
This video demonstrates a method for generating a mouse aortic interposition model to study alloimmune-induced vascular rejection. After placing an anesthetized donor mouse in the supine position, the infrarenal abdominal aorta (IAA) is carefully isolated from surrounding structures. Branching vessels are ligated, and both ends of the IAA are clamped to prevent blood flow before resection. Subsequently, the donor IAA is implanted into an allogeneic recipient mouse, and blood flow is restored...
FAQs
The graft creates a new conduit for blood flow while shielding the weakened aortic segment from direct arterial pressure. By carrying circulation across or around diseased tissue, it reduces the mechanical stress placed on the damaged vessel wall. This pressure-isolating function is central to treating aneurysms and lowering the risk of rupture.
Accurate positioning places the graft across the affected aortic segment, while secure connections help maintain continuous blood flow through the repair. These connections also prevent arterial pressure from acting directly on the diseased wall. Together, placement and attachment determine whether the repair restores circulation and effectively isolates the damaged area.
The two approaches differ primarily in how the graft reaches the diseased aortic segment. Open surgery allows surgeons to position the graft directly during repair, whereas a catheter-based endovascular procedure delivers it through the vascular system. Both approaches aim to restore blood flow and separate the weakened vessel wall from arterial pressure.
Repair begins by identifying the diseased portion of the aorta and selecting a suitable graft approach. Surgeons then position the graft across the affected segment or use it to bypass that area, followed by creating secure vascular connections. The completed repair should restore blood flow while isolating damaged tissue from ongoing arterial pressure.
Aortic grafts may be used when the aorta has an aneurysm, dissection, traumatic injury, or degenerative disease. The repair can replace, reinforce, or bypass the affected section, depending on the condition and the chosen procedure. These applications share the goal of protecting the aorta while preserving circulation through the major arterial pathway.
Successful graft repair supports durable circulation and reduces the exposure of weakened aortic tissue to arterial pressure. By addressing structural disease as well as blood-flow continuity, grafts contribute to preventing catastrophic vessel failure. Their use in both open and endovascular repair also supports continuing advances in vascular and cardiovascular medicine.