Mouse Inner Ear
Mouse Inner Ear - Related Videos
04:36
Canalostomy for Local Drug Delivery into the Inner Ear of an Adult Mouse
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2025
This video showcases canalostomy, a procedure that allows local drug delivery into the inner ear of a mouse through the semicircular canal with minimal damage to hearing and vestibular function. This method enables the inoculation of viral vectors, pharmaceuticals, and small molecules into the mouse's inner ear.
04:41
Isolating Vestibular Ganglion Neurons From a Mouse Inner Ear
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2025
This video showcases a method for isolating vestibular neurons from a mouse pup's inner ear. It meticulously outlines the steps involved in dissecting the inner ear, harvesting the vestibular ganglion, and subsequently dissociating the ganglion into single cells. These cells are then cultured on glass-bottom dishes to establish a vestibular neuron culture.
06:35
Generating Primary Fibroblast Cultures from Mouse Ear and Tail Tissues
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Cited by 95 •
2016
We describe a simple and quick experimental procedure for generating primary fibroblasts from the ears and tails of mice. The procedure does not require special animal training and can be used for the generation of fibroblast cultures from ears stored at RT for up to 10 days.
09:10
Ear Exam
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2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video describes the examination of the ear, beginning with a review of its surface and interior anatomy (Figure 1). The cartilaginous auricle consists of the helix, antihelix, earlobe, and tragus. The mastoid process is positioned just behind the earlobe. The slightly curving auditory canal ends at the tympanic membrane, which transmits sound...
22:02
Gene Transfer to the Developing Mouse Inner Ear by In Vivo Electroporation
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Cited by 23 •
2012
The mouse inner ear is a placode-derived sensory organ whose developmental program is elaborated during gestation. We define an in utero gene transfer technique consisting of three steps: mouse ventral laparotomy, transuterine microinjection, and in vivo electroporation. We use digital video microscopy to demonstrate the critical experimental embryological techniques.
FAQs
The cochlea and vestibular labyrinth support different sensory functions before signals enter the brain. In the cochlea, mechanical vibrations are associated with sound detection; in the vestibular labyrinth, fluid movements are associated with head movement and balance. Hair cells in these compartments transduce those physical inputs into electrical signals, allowing researchers to compare auditory and vestibular pathways within one model.
Hair cells are the transduction interface between mechanical inputs and neural signaling in the mouse inner ear. They respond to vibrations or fluid movements and convert those stimuli into electrical signals. Those signals then travel through auditory or vestibular nerve pathways, providing a basis for studying how sensory information reaches the brain.
Genetic and environmental changes can alter the sensory system, making them useful experimental variables in mouse inner ear research. Researchers can examine how such changes affect neural circuit development, sensory processing, hearing, or balance. Because mouse genetics are well characterized, the model helps connect a defined change with altered auditory or vestibular outcomes.
Imaging and electrophysiology provide complementary ways to study the mouse inner ear. Imaging can support examination of inner-ear structures, while electrophysiology can examine electrical signaling. Researchers can pair these approaches with the mouse's well-characterized genetics to investigate development, sensory processing, or disorder-related changes, and to assess responses relevant to potential therapies.
Anatomical accessibility makes the mouse inner ear practical for direct experimental investigation. It supports imaging and electrophysiology, while the established genetic background helps researchers examine defined biological changes. These features allow studies to connect inner-ear alterations with neural circuit development, sensory processing, and hearing or balance disorders.
Researchers select the mouse inner ear when they need a model that links sensory-organ biology with neuroscience questions. It is used to study neural circuit development, auditory and vestibular sensory processing, hearing and balance disorders, and the effects of genetic or environmental changes. The same platform also supports evaluation of potential therapies for sensory loss.