Ernest Rutherford

Ernest Rutherford was a New Zealand-born physicist whose experiments established the nuclear structure of the atom and transformed modern physics. By directing alpha particles at thin metal foils and analyzing their scattering, he showed that most of an atom is empty space while nearly all its positive charge and mass are concentrated in a tiny nucleus. Rutherford also investigated radioactive decay, identifying transmutation and helping establish the concept of half-life. His findings replaced earlier models of atomic structure, provided foundations for nuclear physics and chemistry, and influenced later research on isotopes, nuclear reactions, and atomic energy.

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Education

JoVE Core - Chemistry

Subatomic Particles

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2020

Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...

Nuclear Transmutation

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2020

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...

Research

JoVE Journal - Biology

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

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Cited by 3 •

2021

In this protocol, we present the experimental procedures of a cell spreading assay that is based on live-cell microscopy. We provide an open-source computational tool for the unbiased segmentation of fluorescently labeled cells and quantitative analysis of lamellipodia dynamics during cell spreading.

Research

JoVE Journal - Developmental Biology
Free Sample

Ex Vivo Perfusion of the Rodent Placenta

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Cited by 21 •

2019

Here is presented a protocol of ex vivo maternal-fetal vascular perfusion to enable the administration of a test article into maternal vasculature and to evaluate placental transfer of xenobiotic particles or pharmacological agents in addition to alterations in placental physiology.

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

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2021

The protocol presented here enables automated fabrication of micropatterns that standardizes cell shape to study cytoskeletal structures within mammalian cells. This user-friendly technique can be set up with commercially available imaging systems and does not require specialized equipment inaccessible to standard cell biology laboratories.

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