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Journal / Immunology and Infection / The Citrobacter rodentium Mouse Model: Studying…
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Immunology and Infection

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JoVE Journal Immunology and Infection
The Citrobacter rodentium Mouse Model
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The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis

Article DOI: 10.3791/50222 • 11:04 min • February 19th, 2013
February 19th, 2013 •
1, 1, 1, 1, 1, 1
1Division of Gastroenterology, BC Children's Hospital

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Summary
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Citrobacter rodentium infection provides a valuable model to study enteric bacterial infections as well as host immune responses and colitis in mice. This protocol outlines the measurement of barrier integrity, pathogen load and histological damage allowing for the thorough characterization of pathogen and host contributions to murine infectious colitis.

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Citrobacter Rodentium Mouse Model Pathogen Host Contributions Infectious Colitis Gram Negative Bacterial Pathogen Enteropathogenic E. Coli Enterohemorrhagic E. Coli Immunocompetent Mice Weight Loss Diarrhea Intestinal Crypt Elongation Immune Cell Infiltration Goblet Cell Depletion Clearance Of Infection Intestinal Epithelial Barrier Integrity Bacterial Load Histological Damage Mouse Strains Susceptible To Infection Virulence Mechanisms Enteric Bacterial Infection Inflammatory Bowel Diseases (IBDs)
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