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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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JoVE Journal Chemistry
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

DOI:
10.3791/51299-v

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13:37 min

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June 20, 2014

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,
1Scripps Florida,The Scripps Research Institute

Chapters

  • 00:05Title
  • 01:43Preparation of Acid Bromide from Natural Amino Acids and Isotopic Labeling of Alanine Using Transaminase
  • 04:39Synthesis of Peptoid Linker Region
  • 06:15Split-and-pool Synthesis of PTA Library with (R)- and (S)-2-bromopropionic Acids
  • 11:10Results: Characterization of a One-Bead-One-Compound Peptide Tertiary Amine Library
  • 13:00Conclusion

Summary

Automatic Translation

Automatic Translation

Peptide tertiary amides (PTAs) are a superfamily of peptidomimetics that include but are not limited to peptides, peptoids and N-methylated peptides. Here we describe a synthetic method which combines both split-and-pool and sub-monomer strategies to synthesize a one-bead one-compound library of PTAs.

Tags

Keywords: Peptide Tertiary AmidesPeptidomimeticsPeptoidsProtein LigandsSplit-and-pool SynthesisCombinatorial ChemistryOne-bead One-compound LibraryConformational Constraints

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