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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
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Medicine
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JoVE Journal Medicine
Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

DOI:
10.3791/51495-v

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10:31 min

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December 28, 2014

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, , , , , ,
1W. M. Keck Center for Transgene Research,University of Notre Dame, 2Department of Chemistry and Biochemistry,University of Notre Dame, 3Notre Dame Integrated Imaging Facility,University of Notre Dame, 4Department of Biological Sciences,University of Notre Dame, 5Harper Cancer Research Institute,University of Notre Dame

Chapters

  • 00:05Title
  • 01:44Animal Stroke Initiation
  • 05:23Image Acquisition
  • 06:36Image Analysis
  • 08:52Results: PET-CT Data of Rats Before and After Cerebral Ischemia
  • 10:01Conclusion

Summary

Automatic Translation

Automatic Translation

Brain damage resulting from cerebral ischemia may be non-invasively imaged and studied in rats using pre-clinical positron emission tomography coupled with the injectable radioactive probe, 18F-fluorodeoxyglucose. Further, the use of modern software tools that include volume of interest (VOI) brain templates dramatically increase the quantitative information gleaned from these studies.

Tags

Keywords: Cerebral IschemiaStrokePositron Emission TomographyFDG-PETMiddle Cerebral Artery OcclusionMCAORat Model3D VisualizationVOI Template Atlas

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