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Modeling Chemotherapy Resistant Leukemia In Vitro
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Modeling Chemotherapy Resistant Leukemia In Vitro

Article DOI: 10.3791/53645-v • 08:41 min • February 9th, 2016
February 9th, 2016 •
*1, *1, 1, 1, 1,2, 1, 1, 1,3
1Alexander B. Osborn Hematopoietic Malignancy and Transplantation Program of the Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, 2Department of Neurobiology and Anatomy, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine, 3Department of Microbiology, Immunology and Cell Biology, Robert C. Byrd Health Sciences Center, West Virginia University School of Medicine
* These authors contributed equally

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Summary
Automatic Translation

The current report summarizes a protocol that can be utilized to model the influence of the bone marrow microenvironment niche on leukemic cells with emphasis placed on enrichment of the most chemoresistant subpopulation.

Tags

Modeling Chemotherapy Resistant Leukemia In Vitro Acute Lymphoblastic Leukemia Refractory ALL Bone Marrow Microenvironment Chemotherapeutic Resistance Drug Advocacy Animal Models Leukemic Cells Tumor-specific Culture Medium Bone Marrow Stromal Cells Osteoblasts Co-culture Adherent Cell Layer Leukemic Cell Culture Medium Floating Leukemic Cells 15 Milliliter Conical Tube Subpopulations
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