Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 Lectin 크로마토그래피/질량 분석 검색 워크플로 공격적인 유방암의 상 Biomarkers를 식별합니다 Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 소설 Lysine Acetylation 사이트 Huntingtin에서의 대량 Spectrometric 식별 합니다 Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker: 시퀀스 태그 지정을 통해 텐 덤 질량 스펙트럼의 품질 평가 Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 3 Nitrotyrosine 수정 여러 질량 분석 플랫폼에서 질량 스펙트럼 데이터의 자신감을 식별 Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 Lectin 선호도 워크플로 인간의 플라즈마 트립 신 소화에서 Glycosite 관련, 암 관련 탄수화물 구조를 대상으로 합니다 Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 식별 새로운 변조기 그리고 단백질 변경 비 Apoptotic 세포 죽음 프로그램 Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 생 단백질 차동 알킬화제와 여러 반응 질량 분석 접근 모니터링을 사용 하 여 사이트별 시스테인 산화의 타겟된 정량 Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 반복성 및 재현성 액체 크로마토그래피 탠덤 질량 분석에 의해 Proteomic 식별에 Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 LC-MS 플랫폼 성능 벤치마킹을 위한 효 모 성능 표준 특성화 연구실 연구 Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Proteomics 분석에서 액체 크로마토그래피 탠덤 질량 분석 시스템에 대 한 성능 메트릭 Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 Mycobacterium Bovis Bacille Calmette 압바스 Phagosome 프로테옴 Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 티로신-39 파 킨 슨 병의 세포 산화 모델에서 알파-synuclein의 Nitration 우선적으로 증가 Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 다중 사이트 평가 정밀도 및 플라즈마에 단백질의 여러 반응 모니터링 기반 측정의 재현성 Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: 높은 차별 펩 티 드 식별 필터링으로 개선 된 단백질 어셈블리 Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Posttranslational 수정 인간 에스트로겐 수용 체-알파 소설 인 산화 사이트에 중점을 두고 체계적인 매핑 Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 인간의 유방암 세포에서 에스트로겐 수용 체의 N 맨끝 도메인에서 소설 떠들고 인 산화 사이트 격리 Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Lysine 잔류물의 부분 Acetylation Intraprotein 교가 향상 됩니다 Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 LpxL, Francisella Tularensis의 후반 Acyltransferase의 식별 Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 미토 콘 드 리아 산화 스트레스 원인 타우의 Hyperphosphorylation PloS One. 2007 | Pubmed ID: 17579710 시 토 크롬 C 산화 효소 효소 활동 및 금액의 높은 스루풋 멀티플렉싱 분석용의 소규모 Immunopurification Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Francisella Tularensis, Francisella Novicida, 및 Francisella Philomiragia 다중 단계 질량 분석 및 매트릭스 보조 레이저 탈 착/이온화를 사용 하 여 중간 진공 소스 선형 이온 트랩에 지질 A Acylation 패턴의 특성 분석 Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 유방암 세포에서 Quinone 유발 스트레스와 관련 된 새로운 경로 Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Huntingtin 인 산화 사이트 질량 분석으로 매핑됩니다. 절단, 독성의 변조입니다 The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 호박 효소 및 Ubiquinol-시 토 크롬 C Reductase (복잡 한 II 및 III) 소 마우스 심장 미토 콘 드리 아에서 Immunoprecipitation에 의해 절연 Proteomic 분석 Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 알 츠 하이 머 병에 녹말 체 전조 인터의 파일럿 Proteomic 연구 Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 소설 인 산화의 대량 Spectrometric 식별 사이트 소 단위 NDUFA10 소 미토 콘 드 리아 복잡 한 나 FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 빠른 정화 및 미토 콘 드리 아 NADH 효소의 대량 Spectrometric 특성화 (복잡 한 나) 설치류 두뇌에서 Dopaminergic 신경 세포 라인 Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 지질 Francisella A Tularensis의 소설 수정입니다 Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 DltA, 소설 Lectin는 Haemophilus Ducreyi에 전체 혈 청 저항 형의 표현에 대 한 필요 합니다 Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 Proteomic 및 성체에 Stathmin에 대 한 역할의 Immunochemical 특성 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 Endoplasmic 그물 스트레스에 의해 활성화 된 세포 죽음 통로의 분자 구성 요소 The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Isotopically 라는 가교 시 약: Crosslinked 펩 티 드 식별에서 대량 축 퇴의 해상도 Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 단백질 인 산화의 사이트 매핑을 위한 Phosphospecific 베이스입니다 Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, 자동 할당 및 화학적 Crosslinked 펩 티 드의 텐 덤 질량 스펙트럼의 명칭 Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 L 분 소포에 Cathepsin Enkephalin 펩타이드 신경 전달 물질의 생산을 위한 Prohormone 처리 효소로 작동합니다 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 부자연 스러운 Sialic 아미노산 대사 없이 Haemophilus Ducreyi Lipooligosaccharides에 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Haemophilus Ducreyi 포함 하는 Polylactosamine에서에서 Lipooligosaccharides 특성을 반복 합니다 Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology 정량화 및 사이트 현지화를 위한 두 가지 번역 후 수정의 동시 선호도 강화 Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology 사이트별 단백질 Lysine Acetylation 및 Succinylation 산출할 데이터 독립적인 수집 질량 분석을 사용 하 여 정량화 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology 복잡한 생물 학적 샘플에서 선택적으로 - glycosylated 펩티드을 풍요롭게하는 렉틴 HPLC 방법 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
정량화 및 사이트 현지화를 위한 두 가지 번역 후 수정의 동시 선호도 강화 Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
사이트별 단백질 Lysine Acetylation 및 Succinylation 산출할 데이터 독립적인 수집 질량 분석을 사용 하 여 정량화 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
복잡한 생물 학적 샘플에서 선택적으로 - glycosylated 펩티드을 풍요롭게하는 렉틴 HPLC 방법 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology