Histological Staining of Spinal Cord for Assessing EAE Disease Severity

February 23rd, 2024

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Carmen C. Ucciferri¹, Annette Gower², Nuria Alvarez-Sanchez^1,2, Heather Whetstone³, Valeria Ramaglia¹, Jennifer L. Gommerman¹, Koroboshka Brand-Arzamendi², Raphael Schneider^2,4, Shannon E Dunn^1,2,5

¹Department of Immunology, University of Toronto, ²Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, ³Sickkids Research Institute, The Hospital for Sick Children, ⁴BARLO MS Centre, St. Michael’s Hospital, ⁵Women’s College Research Institute, Women’s College Hospital

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L’encéphalomyélite auto-immune expérimentale (EAE) sert de modèle animal de la sclérose en plaques. Cet article décrit une approche permettant d’évaluer l’inflammation, la démyélinisation et les lésions axonales de la moelle épinière dans l’EAE. De plus, une méthode permettant de quantifier les niveaux de lumière des neurofilaments solubles dans le sérum de souris est présentée, facilitant l’évaluation des lésions axonales chez les souris vivantes.

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Histological Staining of Spinal Cord for Assessing EAE Disease Severity

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