Adolescent Mice Exposure
Adolescent Mice Exposure - Related Videos
02:40
Induction and Evaluation of Depression in Mice Through Chronic Stress Exposure
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2025
Source: Yan, Z., et al. Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice. J. Vis. Exp. (2019).The video demonstrates the process of establishing a mouse model of chronic stress-induced depression and assessing depressive behaviors. The chronic application of various stressors triggers the release of corticosterone, leading to neuronal over-excitation and eventual neuronal death, which results in depression-like symptoms in the mice.
01:52
Inducing Hearing Loss in Mice Through Prolonged High-Volume Sound Exposure
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2025
Source: Lee, D. et. al., Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage. J. Vis. Exp. (2023)This video demonstrates the procedure of noise-induced hearing loss in mice. High-volume sound damages hair cells in the inner ear and disrupts auditory pathways, resulting in hearing impairment.
07:06
Chronic Social Defeat Stress in Early Adolescent Male Mice
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Cited by 3 •
2025
This protocol details how to perform 10 day chronic social defeat stress in early adolescent male mice to produce long-lasting social avoidance in adulthood in more than 60% of mice.
06:15
A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
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Cited by 17 •
2017
Here, we present a protocol that provoked cortisol reactivity in a vulnerable adolescent Mexican American sample utilizing a modified version of the Trier Social Stress Test (TSST). Saliva samples were collected at baseline, 15, 30, and 45 min post-TSST onset. Future research could utilize this modified TSST with vulnerable youth.
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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Cited by 7 •
2017
This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.
FAQs
Timing matters because adolescence includes ongoing brain and behavioral maturation. An exposure during this stage can therefore be evaluated not only as an immediate challenge, but also in relation to later behavioral outcomes. Comparing results across developmental stages can help determine whether sensitivity depends on when the exposure occurs, making age selection a central design variable in behavior studies.
Duration, intensity, and route determine the conditions under which the mice encounter the stimulus, substance, environment, or stressor. Keeping these factors controlled allows researchers to relate behavioral differences to the exposure rather than to inconsistent experimental conditions. Recording them also makes comparisons between exposed and unexposed groups more interpretable.
Researchers may examine activity, learning, social interaction, anxiety-like responses, and reward-related behavior. These measures represent different aspects of behavioral function, so a change in one domain does not automatically indicate a change in all others. Selecting several relevant measures can help describe whether an exposure is associated with a broad or more specific behavioral outcome.
Unexposed control animals provide a comparison for behavioral measures collected from exposed mice. This comparison helps identify differences associated with the controlled exposure rather than simply describing behavior in the exposed group. Controls are especially important when interpreting activity, learning, social interaction, anxiety-like responses, or reward-related behavior during a period of normal developmental change.
A study first identifies the adolescent developmental stage and the exposure conditions, including timing, duration, intensity, and route. Researchers then compare mice receiving the controlled exposure with unexposed controls and collect behavioral measures relevant to the research question. Standardizing these elements supports clearer links between the developmental exposure and observed behavioral outcomes.
Researchers use adolescent exposure studies when they want to examine how a developmental condition relates to later behavior. The approach can model encounters with a controlled substance, environment, stressor, or sensory stimulus, then assess outcomes such as learning, social interaction, activity, anxiety-like responses, or reward-related behavior. It provides a controlled way to connect environmental influences with neurobehavioral development.
Behavioral testing can show whether exposed mice differ from unexposed controls in activity, learning, social interaction, anxiety-like responses, or reward-related behavior. These outcomes help characterize the behavioral consequences associated with the exposure and developmental timing. Because adolescence involves maturation, the findings can also inform how environmental conditions relate to later neurobehavioral development.