Cerebral Blood Vessel
Cerebral Blood Vessel - Related Videos
08:22
Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
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Cited by 16 •
2013
We describe a highly reproducible method for the permanent occlusion of a rodent major cerebral blood vessel. This technique can be accomplished with very little peripheral damage, minimal blood loss, a high rate of long-term survival, and consistent infarct volume commensurate with the human clinical population.
13:16
Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
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Cited by 16 •
2013
Analysis of rodent cerebrovascular anatomy plays an important role in experimental stroke research. In this context, intravascular perfusion with colored latex has been considered as a standard tool for several years. However, this technique implies distinct technical limitations, which undermine its reproducibility. Here, we describe a simple method to visualize cerebral vessels in a reproducible manner. Injection of a mixture of two commercially available carbon black inks through the left...
10:01
En Face Preparation of Mouse Blood Vessels
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Cited by 20 •
2017
A procedure for making en face preparations of the mouse carotid artery and aorta is described. Such preparations, when immunofluorescently stained with specific antibodies, enable us to study localization of proteins and identification of cell types within the entire vascular wall by confocal microscopy.
03:38
Developing a Cerebral Blood Flow Atlas for Blood Flow Mapping
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2025
Source: Tan, Z., et al., Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling. J. Vis. Exp. (2024).This video demonstrates the method to construct a cerebral blood flow atlas by integrating magnetic resonance imaging or MRI-arterial spin labeling data with segmented brain regions, visualizing blood flow patterns, and quantifying flow levels across functional areas.
01:16
Visualizing Cerebral Blood Flow During Ischemia in a Mouse Using a Fluorescent Tracer
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2025
Make a neck incision to expose and loosely ligate the bilateral common carotid arteries.
FAQs
Smooth muscle in vessel walls changes vessel diameter by constricting or relaxing. These changes alter resistance to blood flow, allowing cerebral circulation to respond to local needs. Because vessel caliber can change rather than remain fixed, the brain can adjust delivery while limiting excessive flow. This mechanism helps maintain appropriate perfusion for active neural tissue.
The blood-brain barrier depends on cerebral capillary endothelial cells, which selectively control movement between the bloodstream and neural tissue. This selectivity helps regulate which substances reach the brain environment while also supporting the removal of metabolic waste through circulation. Barrier control is therefore important when researchers examine how vascular function affects neuronal survival and brain function.
Neurovascular coupling links neuronal activity with local blood supply, so regions with greater activity receive adjustments in circulation that match their metabolic demand. Autoregulation addresses a different challenge by helping stabilize cerebral perfusion when systemic blood pressure changes. Considering both processes allows researchers to distinguish activity-related local control from broader protection against pressure fluctuations.
Research on cerebral blood vessels provides a way to investigate how impaired circulation or vascular regulation may contribute to stroke, brain tumors, neurodegenerative disease, and vascular malformations. The same research can examine effects on perfusion, selective exchange, and waste removal, linking vascular changes to neuronal survival and overall brain function.
Therapeutic studies can use this vascular framework when the goal is to protect or restore brain circulation. Researchers may assess whether an intervention preserves appropriate perfusion, supports vessel mechanisms that respond to neural activity or pressure changes, or maintains selective endothelial control. These outcomes connect vascular effects with protection of neuronal function.
Researchers can evaluate cerebral vessel function through its consequences for perfusion, exchange across the blood-brain barrier, metabolic waste removal, neuronal survival, and brain function. This outcome-oriented perspective is useful because it connects vessel behavior with neural health rather than treating circulation as an isolated biological process.