Somatic Cells
Somatic Cells - Related Videos
07:06
Tissue Regeneration with Somatic Stem Cells
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2023
Somatic or adult stem cells, like embryonic stem cells, are capable of self-renewal but demonstrate a restricted differentiation potential. Nonetheless, these cells are crucial to homeostatic processes and play an important role in tissue repair. By studying and manipulating this cell population, scientist may be able to develop new regenerative therapies for injuries and diseases. This video first defines somatic stem cells, and then explores the role these cells play in tissue regeneration.
04:36
A Simple Microaspiration Technique for Isolating Somatic Cells from Cryopreserved Equine Semen as Nuclear Donors for Cloning
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2025
This protocol presents a simple microaspiration technique to isolate viable somatic cells (SCs) from cryopreserved equine semen. Unlike traditional approaches, this technique avoids long in vitro cultures and overcomes sperm contamination, enabling immediate use in somatic cell cloning.
08:12
Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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Cited by 5 •
2011
We describe how to perform retroviral or lentiviral infections of overexpression or shRNA-containing constructs in the human Ramos B-cell line and how to measure somatic hypermutation in these cells.
09:43
Efficient Generation Human Induced Pluripotent Stem Cells from Human Somatic Cells with Sendai-virus
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Cited by 13 •
2014
Here, we present our established method to reprogram human somatic cells into transgene-free human iPSCs with Sendai virus, which shows consistent outcome and enhanced efficiency.
01:29
Somatic to iPS Cell Reprogramming
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2023
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
FAQs
During the cell cycle, DNA is replicated before mitosis, allowing a dividing cell to distribute genetic material into two daughter cells. Because the daughter cells are genetically similar, this sequence supports the maintenance and replacement of body tissues. The same process also provides opportunities for DNA changes to arise and accumulate, linking normal tissue renewal with disease-related research.
DNA changes that accumulate in somatic cells can alter how tissues function and help explain why disease develops over time. This is especially important in cancer research, where investigators examine how mutations acquired during cell-cycle activity may contribute to abnormal tissue behavior. Tracking these changes connects ordinary cellular renewal with long-term patterns of disease and aging.
Most human somatic cells carry two sets of chromosomes, and DNA replication prepares that genetic material for division. Mitosis then produces daughter cells that are genetically similar, helping preserve the chromosome complement as tissues grow or undergo repair. This relationship between chromosome content, replication, and division is central to understanding how body tissues are maintained.
Studying somatic cells from tissues such as muscle, skin, and the nervous system helps researchers examine how the cell cycle supports growth and tissue repair. Comparing these cellular contexts can connect shared processes, such as replication and mitosis, with the needs of particular tissues. This makes somatic-cell research relevant to understanding how organisms maintain and restore body structures.
Somatic-cell analysis gives cancer research a way to focus on DNA changes that accumulate as body tissues pass through the cell cycle. Researchers can relate those mutations to disease development, rather than examining cancer only as a general growth problem. This perspective links cell-cycle activity, tissue biology, and disease mechanisms within the same biological system.
Beyond cancer, somatic-cell research supports genetics, developmental biology, regenerative medicine, and cell-based therapies. In genetics and development, it helps connect cellular behavior with organismal growth; in regenerative medicine and therapy research, it supports work on restoring or replacing damaged tissue. These applications extend the value of studying replication, mitosis, and DNA changes beyond basic cell biology.