Tunica Externa

The tunica externa is the outermost layer of a blood vessel wall, providing structural support and helping anchor the vessel to surrounding tissues. It consists mainly of connective tissue, including collagen and elastic fibers, which resist excessive stretching while allowing limited movement as blood pressure changes; in larger vessels, it may also contain small blood vessels and nerves that supply the vessel wall. Studying the tunica externa helps explain how arteries and veins maintain their shape, withstand mechanical stress, and interact with adjacent organs. Its organization is therefore important in vascular anatomy, circulation, and research on vessel injury and disease.

Tunica Externa - Related Videos

Research

JoVE Journal - Medicine

Urethroplasty with Pedicled Tunica Vaginalis for the Treatment of Long-segment Anterior Urethral Stricture Caused by Lichen Sclerosus of Glans Penis

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Cited by 1 •

2024

This article introduces a surgical method using a pedicled tunica vaginalis to treat long-segment urethral stricture resulting from lichen sclerosus. The tunica vaginalis is an excellent substitute for the urethra, leading to quick postoperative recovery for patients.

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

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Cited by 32 •

2012

Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.

A Mouse Aortic Interposition Model to Study Alloimmune-Induced Vascular Rejection

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2025

This video demonstrates a method for generating a mouse aortic interposition model to study alloimmune-induced vascular rejection. After placing an anesthetized donor mouse in the supine position, the infrarenal abdominal aorta (IAA) is carefully isolated from surrounding structures. Branching vessels are ligated, and both ends of the IAA are clamped to prevent blood flow before resection. Subsequently, the donor IAA is implanted into an allogeneic recipient mouse, and blood flow is restored...

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

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Cited by 7 •

2015

We describe a protocol for aortic interposition grafting in mice. The goal of the protocol is to provide a model with which to study pathological processes and therapeutic strategies relevant to alloimmune reactions in arteries and the resultant arterial changes that contribute to organ transplant failure.

Performing Cavernous Nerve Stimulation in Rats to Measure Intracavernous Pressure

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2025

This video demonstrates the isolation and stimulation of the cavernous nerve in an anesthetized rat to study blood pressure changes in the cavernous body.

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