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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis
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Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Article DOI: 10.3791/52800 • 07:05 min • May 17th, 2015
May 17th, 2015 •
1, 1, 1
1Department of Molecular Biology and Biochemistry, Simon Fraser University

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We describe a protocol for aortic interposition grafting in mice. The goal of the protocol is to provide a model with which to study pathological processes and therapeutic strategies relevant to alloimmune reactions in arteries and the resultant arterial changes that contribute to organ transplant failure.

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Mouse Model Alloimmune-induced Vascular Rejection Transplant Arteriosclerosis Chronic Heart Transplant Failure Immune System Arterial Wall Damage Endothelial Cells Smooth Muscle Cells Intimal Thickening Luminal Occlusion Pathological Repair Response Novel Ways To Manage Graft Failure Mouse Aortic Interposition Model Allogeneic Recipient Alloimmune Reactions Vascular Changes
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