Drug Delivery Methods
Drug Delivery Methods - Related Videos
18:57
Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Cited by 58 •
2013
Many therapeutic applications require safe and efficient transport of drug carriers and their cargoes across cellular barriers in the body. This article describes an adaptation of established methods to evaluate the rate and mechanism of transport of drug nanocarriers (NCs) across cellular barriers, such as the gastrointestinal (GI) epithelium.
05:10
Intrarenal Drug Delivery in Rats: A Method to Deliver Therapeutic Drugs in Rat Kidney via Intra-arterial Injection
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2023
In this video, we demonstrate intra-renal drug administration in rats via the renal artery. This method is beneficial in improving drug targeting, drug potency, and minimizing systemic toxicity.
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
05:53
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Cited by 5 •
2016
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Cited by 49 •
2016
Nanoparticles are emerging as promising drug delivery systems for a broad range of indications. Here, we describe a simple yet powerful method to manufacture silk nanoparticles using reverse engineered Bombyx mori silk. These silk nanoparticles can be readily loaded with a therapeutic payload and subsequently explored for drug delivery applications.
FAQs
Drug properties help determine whether oral, injectable, inhaled, topical, or transdermal administration is appropriate. The selected route affects absorption, distribution, metabolism, and elimination, which in turn shape the drug’s exposure at its site of action. Matching these characteristics with patient and disease needs can support effectiveness while limiting unnecessary exposure and adverse effects.
Immediate-release formulations make a drug available without intentionally extending its delivery over time, whereas controlled-release systems regulate when and how quickly the agent becomes available. This distinction influences timing, dose exposure, and treatment schedules. Controlled release can be useful when maintaining drug availability over a planned period supports treatment goals or simplifies administration.
Targeted carriers are designed to help transport therapeutic agents toward intended sites of action rather than relying only on general distribution. By focusing delivery, they may help align drug exposure with the location of disease and reduce exposure elsewhere. Their development is especially relevant to complex conditions in which conventional administration may not provide sufficient targeting.
The route determines how a therapeutic agent enters the body and reaches the site where it acts. Oral, injectable, inhaled, topical, and transdermal routes can therefore produce different patterns of absorption and subsequent distribution, metabolism, and elimination. These differences may influence effectiveness, adverse effects, dosing timing, and how consistently patients can follow treatment.
Selection should match the drug’s properties with the patient’s condition, the disease site, desired timing of exposure, and practical treatment needs. Clinicians may also consider whether immediate or controlled release is more suitable and whether the route supports adherence. This structured matching helps balance therapeutic effectiveness, dose control, adverse-effect reduction, and patient usability.
Sustained-release systems are useful when treatment benefits from drug availability over an extended period rather than from repeated immediate delivery. They can help control exposure and timing while potentially supporting adherence through less frequent administration. Their relevance extends to complex medical conditions, where maintaining an appropriate delivery pattern may be important for achieving the intended therapeutic effect.
Personalized administration adapts delivery choices to individual patient and disease needs instead of applying one route or formulation universally. Options such as different administration routes, controlled-release systems, and targeted carriers provide ways to adjust exposure, timing, and site of action. This flexibility can support more appropriate treatment selection as medicine addresses increasingly complex conditions.
Current advances described for medicine include targeted carriers, sustained-release systems, and personalized administration. These approaches seek greater control over where and when therapeutic agents become available, while accounting for patient and disease differences. Together, they broaden the possible strategies for treating complex conditions and may improve the balance between treatment effectiveness, adverse effects, and adherence.