Localized Drug Delivery
Localized Drug Delivery - Related Videos
04:36
Canalostomy for Local Drug Delivery into the Inner Ear of an Adult Mouse
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2025
This video showcases canalostomy, a procedure that allows local drug delivery into the inner ear of a mouse through the semicircular canal with minimal damage to hearing and vestibular function. This method enables the inoculation of viral vectors, pharmaceuticals, and small molecules into the mouse's inner ear.
11:51
Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
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Cited by 42 •
2010
Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.
06:39
Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland
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Cited by 36 •
2013
A protocol for the non-invasive intraductal delivery of aqueous reagents to the mouse mammary gland is described. The method takes advantage of localized injection into the nipples of mammary glands targeting mammary ducts specifically. This technique is adaptable for a variety of compounds including siRNA, chemotherapeutic agents and small molecules.
01:27
Enhancing Drug Delivery in Recurrent Glioblastoma with Laser-Induced Hyperthermia
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2025
Begin with an anesthetized human patient diagnosed with recurrent glioblastoma, an invasive tumor characterized by tumor cell infiltration into the surrounding peritumoral region.The peritumoral region retains an intact blood-brain barrier (BBB), where tight junctions between endothelial cells restrict drug penetration.Make an incision in the scalp, create an opening in the skull, and insert a laser probe into the tumor core using MRI guidance.Deliver laser light through the probe.Tissue...
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
FAQs
Therapeutic performance depends on three linked variables: how long the agent remains at the target, how quickly it is released, and how it travels through nearby tissue. Implanted devices, drug-releasing materials, injections, and engineered carriers can be selected or designed around these variables. Managing them helps maintain treatment at the disease site while reducing unnecessary exposure elsewhere.
Localized Drug Delivery differs from conventional systemic administration mainly in where therapeutic exposure is concentrated. Systemic treatment distributes an agent beyond the intended site, whereas site-directed approaches aim to retain or release more of it near the relevant tissue, organ, or disease site. This distinction can support effectiveness and reduce systemic side effects when treatment needs are anatomically specific.
Sustained release helps keep a therapeutic agent available at the intended site over time rather than relying only on a brief local exposure. Drug-releasing materials and implanted devices are especially relevant to this goal because they can regulate release rate and retention. In medicine, this may support treatments that require continuing therapy at one tissue or disease site.
The choice among an injection, implanted device, drug-releasing material, or engineered carrier depends on the treatment site and the desired control of retention, release rate, and transport. A localized plan therefore connects the therapeutic agent with the anatomy requiring treatment. This approach is particularly relevant when conventional systemic administration would expose tissues beyond the intended region.
The source identifies cancer treatment, wound care, infection management, and therapies for tissues that are difficult to reach through conventional systemic administration. These applications share a need for treatment at a defined site or for continuing local exposure. Localized Drug Delivery can therefore address both disease location and the limitations of broader drug distribution.
The main outcomes are concentration of treatment near the target, potentially improved therapeutic effectiveness, and fewer systemic side effects. These benefits arise when the delivery approach controls retention, release rate, and transport within the target region. Its performance can therefore be considered by examining both whether therapy reaches the site and how well it remains there.