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Biology

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JoVE Journal Biology
Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland
 

Intraductal Injection for Localized Drug Delivery to the Mouse Mammary Gland

Article doi: 10.3791/50692
October 4th, 2013 • Usage Statistics
1, 2, 1,2,3
1Vascular Biology Program, Department of Surgery, Boston Children's Hospital and Harvard Medical School, 2Wyss Institute for Biologically Inspired Engineering, Harvard University, 3Harvard School of Engineering and Applied Sciences

Summary
Automatic Translation
October 4th, 2013

A protocol for the non-invasive intraductal delivery of aqueous reagents to the mouse mammary gland is described. The method takes advantage of localized injection into the nipples of mammary glands targeting mammary ducts specifically. This technique is adaptable for a variety of compounds including siRNA, chemotherapeutic agents and small molecules.

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