Kevin Eggan

Department of Molecular and Cell Biology, Harvard

Affiliated withHarvard Broad Institute of MIT and Harvard Harvard University

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 1	2006
Publication title Cited by 2	2006
Publication title	2006
Publication title Cited by 7	2006
Publication title Cited by 29	2017

Other Publications

Article	Year
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (New York, N.Y.)\| PubMed ID: 18669821	2008
Using stem cells and reprogramming to understand disease. Regenerative medicine\| PubMed ID: 18947303	2008
Flp recombinase regulated lacZ expression at the ROSA26 locus. Genesis (New York, N.Y. : 2000)\| PubMed ID: 11857816	2002
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Molecular and cellular biology\| PubMed ID: 11884600	2002
Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nature biotechnology\| PubMed ID: 11981557	2002
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12235366	2002
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development (Cambridge, England)\| PubMed ID: 12620990	2003
Nuclear cloning, stem cells, and genomic reprogramming. Cloning and stem cells\| PubMed ID: 12630413	2002
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature\| PubMed ID: 14668819	2004
Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Methods in enzymology\| PubMed ID: 14696335	2003
Mice cloned from olfactory sensory neurons. Nature\| PubMed ID: 14990966	2004
Micromanipulating dosage compensation: understanding X-chromosome inactivation through nuclear transplantation. Seminars in cell & developmental biology\| PubMed ID: 15015742	2003
Nuclear cloning, epigenetic reprogramming and cellular differentiation. Novartis Foundation symposium\| PubMed ID: 16050253	2005
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.)\| PubMed ID: 16123299	2005
Ovulated oocytes in adult mice derive from non-circulating germ cells. Nature\| PubMed ID: 16799565	2006
A transcriptional logic for nuclear reprogramming. Cell\| PubMed ID: 16923385	2006
Dolly's legacy: human nuclear transplantation and better medicines for our children. Cloning and stem cells\| PubMed ID: 17386009	2007
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nature neuroscience\| PubMed ID: 17435754	2007
Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature\| PubMed ID: 17554301	2007
The potential of cell fusion for human therapy. Stem cell reviews\| PubMed ID: 17848721	2006
Short-circuiting epiblast development. Cell stem cell\| PubMed ID: 18371343	2007
Mediators of reprogramming: transcription factors and transitions through mitosis. Nature reviews. Molecular cell biology\| PubMed ID: 18568039	2008
Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell stem cell\| PubMed ID: 19041780	2008
Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell stem cell\| PubMed ID: 19200798	2009
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nature biotechnology\| PubMed ID: 19330000	2009
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nature methods\| PubMed ID: 19620972	2009
Reprogramming after chromosome transfer into mouse blastomeres. Current biology : CB\| PubMed ID: 19682906	2009
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell stem cell\| PubMed ID: 19818703	2009
Progress toward the clinical application of patient-specific pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 20051636	2010
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & development\| PubMed ID: 20123909	2010
Recipient cell nuclear factors are required for reprogramming by nuclear transfer. Development (Cambridge, England)\| PubMed ID: 20463036	2010
Shushing down the epigenetic landscape towards stem cell differentiation. Development (Cambridge, England)\| PubMed ID: 20554719	2010
A functionally characterized test set of human induced pluripotent stem cells. Nature biotechnology\| PubMed ID: 21293464	2011
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell\| PubMed ID: 21295703	2011
Somatic coding mutations in human induced pluripotent stem cells. Nature\| PubMed ID: 21368825	2011
Constructing and deconstructing stem cell models of neurological disease. Neuron\| PubMed ID: 21609821	2011
Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell stem cell\| PubMed ID: 21852222	2011
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature communications\| PubMed ID: 21971503	2011
Impracticality of egg donor recruitment in the absence of compensation. Cell stem cell\| PubMed ID: 21982228	2011
Erosion of dosage compensation impacts human iPSC disease modeling. Cell stem cell\| PubMed ID: 22560080	2012
SnapShot: directed differentiation of pluripotent stem cells. Cell\| PubMed ID: 22632979	2012
Developmental bias in cleavage-stage mouse blastomeres. Current biology : CB\| PubMed ID: 23177476	2013
Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse. Developmental biology\| PubMed ID: 23261930	2013
CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature\| PubMed ID: 23474986	2013
Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell stem cell\| PubMed ID: 23642365	2013
Modeling human disease with pluripotent stem cells: from genome association to function. Cell stem cell\| PubMed ID: 23746975	2013
Opportunities and challenges of pluripotent stem cell neurodegenerative disease models. Nature neuroscience\| PubMed ID: 23799470	2013
Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cellular reprogramming\| PubMed ID: 24182315	2013
The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD. Nature neuroscience\| PubMed ID: 24185425	2013
Picking the lock on pluripotency. The New England journal of medicine\| PubMed ID: 24283230	2013
How to make spinal motor neurons. Development (Cambridge, England)\| PubMed ID: 24449832	2014
Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron\| PubMed ID: 24507191	2014
Nanog-independent reprogramming to iPSCs with canonical factors. Stem cell reports\| PubMed ID: 24527385	2014
Gene profiling of human induced pluripotent stem cell-derived astrocyte progenitors following spinal cord engraftment. Stem cells translational medicine\| PubMed ID: 24604284	2014
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons. Cell reports\| PubMed ID: 24703839	2014
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell stem cell\| PubMed ID: 24704492	2014
Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicology and teratology\| PubMed ID: 24746641	2014
Notch inhibition allows oncogene-independent generation of iPS cells. Nature chemical biology\| PubMed ID: 24952596	2014
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts. Molecular biology of the cell\| PubMed ID: 25009283	2014
DNA methylation dynamics of the human preimplantation embryo. Nature\| PubMed ID: 25079558	2014
Genetic validation of a therapeutic target in a mouse model of ALS. Science translational medicine\| PubMed ID: 25100738	2014
The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice. Nature communications\| PubMed ID: 25394724	2014
Genetic variation in human DNA replication timing. Cell\| PubMed ID: 25416942	2014
Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nature neuroscience\| PubMed ID: 25420066	2015
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease. Cell reports\| PubMed ID: 25456120	2014
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25609642	2015
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature communications\| PubMed ID: 25625564	2015
Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England)\| PubMed ID: 25670790	2015
Focus on induced pluripotency and cellular reprogramming. The EMBO journal\| PubMed ID: 25916828	2015
Efficient CRISPR-Cas9-mediated generation of knockin human pluripotent stem cells lacking undesired mutations at the targeted locus. Cell reports\| PubMed ID: 25937281	2015
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial. Cell stem cell\| PubMed ID: 26140603	2015
Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells. Nature methods\| PubMed ID: 26237226	2015
A perspective on stem cell modeling of amyotrophic lateral sclerosis. Cell cycle (Georgetown, Tex.)\| PubMed ID: 26505672	2015
SLC52A3, A Brown-Vialetto-van Laere syndrome candidate gene is essential for mouse development, but dispensable for motor neuron differentiation. Human molecular genetics\| PubMed ID: 26976849	2016
Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature neuroscience\| PubMed ID: 27021939	2016
CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. The Journal of biological chemistry\| PubMed ID: 27405765	2016
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Science translational medicine\| PubMed ID: 27412785	2016
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 27532820	2016
Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nature communications\| PubMed ID: 27796305	2016
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27849576	2016
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem cell research\| PubMed ID: 27879218	2016
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9. Stem cell research\| PubMed ID: 27879221	2016
Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection. Cell stem cell\| PubMed ID: 27912091	2016
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature\| PubMed ID: 28445466	2017
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications. Stem cell reports\| PubMed ID: 28700896	2017
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1. Stem cell reports\| PubMed ID: 28712846	2017
A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease. Stem cell reports\| PubMed ID: 29020615	2017
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons. Stem cell reports\| PubMed ID: 29107592	2017
Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature neuroscience\| PubMed ID: 29184211	2017
Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature neuroscience\| PubMed ID: 29549319	2018
All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS. Stem cell reports\| PubMed ID: 29779896	2018
Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. Cell reports\| PubMed ID: 29791859	2018
TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons. Scientific reports\| PubMed ID: 29802307	2018
The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis. Genes & development\| PubMed ID: 29950492	2018
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta neuropathologica communications\| PubMed ID: 29973287	2018
Hippo signaling in the ovary and polycystic ovarian syndrome. Journal of assisted reproduction and genetics\| PubMed ID: 30120633	2018
All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nature methods\| PubMed ID: 30275587	2018
Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development (Cambridge, England)\| PubMed ID: 30337375	2018
Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development. Translational psychiatry\| PubMed ID: 30352993	2018
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Translational psychiatry\| PubMed ID: 30410030	2018
A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 30446391	2019
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nature neuroscience\| PubMed ID: 30643292	2019
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nature neuroscience\| PubMed ID: 30664768	2019
Comparison of three congruent patient-specific cell types for the modelling of a human genetic Schwann-cell disorder. Nature biomedical engineering\| PubMed ID: 30962586	2019
A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell reports\| PubMed ID: 31533043	2019
Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 31543368	2019
RNA-seq as a tool for evaluating human embryo competence. Genome research\| PubMed ID: 31548358	2019
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience\| PubMed ID: 31768050	2019
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9. eLife\| PubMed ID: 31789594	2019
Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience\| PubMed ID: 31857710	2020
A multiplexed gRNA piggyBac transposon system facilitates efficient induction of CRISPRi and CRISPRa in human pluripotent stem cells. Scientific reports\| PubMed ID: 31959800	2020