David Haake Departments of Medicine, Urology at David Geffen School of Medicine and Department of Microbiology, Immunology and Molecular Gentics University of California Los Angeles (UCLA) Biography Publications Institution JoVE Articles David Haake has not added a biography. If you are David Haake and would like to personalize this page please email our Author Liaison for assistance. Publications Antibodies to a Novel Leptospiral Protein, LruC, in the Eye Fluids and Sera of Horses with Leptospira-associated Uveitis Clinical and Vaccine Immunology : CVI. Jan, 2012 | Pubmed ID: 22237897 Three-Dimensional Structures of Pathogenic and Saprophytic Leptospira Revealed by Cryo-Electron Tomography Journal of Bacteriology. Jan, 2012 | Pubmed ID: 22228733 A LigA Three-domain Region Protects Hamsters from Lethal Infection by Leptospira Interrogans PLoS Neglected Tropical Diseases. Dec, 2011 | Pubmed ID: 22180800 Methylation and in Vivo Expression of the Surface-exposed Leptospira Interrogans Outer Membrane Protein OmpL32 Microbiology (Reading, England). Dec, 2011 | Pubmed ID: 22174381 Target-specific Capture Enhances Sensitivity of Electrochemical Detection of Bacterial Pathogens Journal of Clinical Microbiology. Dec, 2011 | Pubmed ID: 21940468 Highly Sensitive Disposable Nucleic Acid Biosensors for Direct Bioelectronic Detection in Raw Biological Samples Talanta. Sep, 2011 | Pubmed ID: 21807191 Heterologous Expression of Pathogen-specific Genes LigA and LigB in the Saprophyte Leptospira Biflexa Confers Enhanced Adhesion to Cultured Cells and Fibronectin BMC Microbiology. 2011 | Pubmed ID: 21658265 Interactions of Leptospira with Environmental Bacteria from Surface Water Current Microbiology. Jun, 2011 | Pubmed ID: 21479795 Ternary Monolayers As DNA Recognition Interfaces for Direct and Sensitive Electrochemical Detection in Untreated Clinical Samples Biosensors & Bioelectronics. Apr, 2011 | Pubmed ID: 21377347 The Multifunctional LigB Adhesin Binds Homeostatic Proteins with Potential Roles in Cutaneous Infection by Pathogenic Leptospira Interrogans PloS One. 2011 | Pubmed ID: 21347378 Redox Cycling Amplified Electrochemical Detection of DNA Hybridization: Application to Pathogen E. Coli Bacterial RNA Analytica Chimica Acta. Mar, 2011 | Pubmed ID: 21338752 Laser Induced Shockwaves on Flexible Polymers for Treatment of Bacterial Biofilms Studies in Health Technology and Informatics. 2011 | Pubmed ID: 21335826 Bacterial Biofilm Disruption Using Laser Generated Shockwaves Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2010 | Pubmed ID: 21096997 Ternary Surface Monolayers for Ultrasensitive (Zeptomole) Amperometric Detection of Nucleic Acid Hybridization Without Signal Amplification Analytical Chemistry. Sep, 2010 | Pubmed ID: 20883023 The OmpL37 Surface-exposed Protein is Expressed by Pathogenic Leptospira During Infection and Binds Skin and Vascular Elastin PLoS Neglected Tropical Diseases. 2010 | Pubmed ID: 20844573 Transcriptional Response of Leptospira Interrogans to Iron Limitation and Characterization of a PerR Homolog Infection and Immunity. Nov, 2010 | Pubmed ID: 20805337 Leptospira: a Spirochaete with a Hybrid Outer Membrane Molecular Microbiology. Jun, 2010 | Pubmed ID: 20598085 A Microfluidic Cartridge System for Multiplexed Clinical Analysis JALA (Charlottesville, Va.). Dec, 2009 | Pubmed ID: 20161584 Potentiometric Detection of DNA Hybridization Using Enzyme-induced Metallization and a Silver Ion Selective Electrode Analytical Chemistry. Dec, 2009 | Pubmed ID: 19908886 Multiplex Pathogen Identification for Polymicrobial Urinary Tract Infections Using Biosensor Technology: a Prospective Clinical Study The Journal of Urology. Dec, 2009 | Pubmed ID: 19837423 A Comprehensive Approach to Identification of Surface-exposed, Outer Membrane-spanning Proteins of Leptospira Interrogans PloS One. 2009 | Pubmed ID: 19562037 Leptospira Interrogans Stably Infects Zebrafish Embryos, Altering Phagocyte Behavior and Homing to Specific Tissues PLoS Neglected Tropical Diseases. 2009 | Pubmed ID: 19547748 Genetic Diversity of the Leptospiral Immunoglobulin-like (Lig) Genes in Pathogenic Leptospira Spp Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Mar, 2009 | Pubmed ID: 19028604 An Unsteady Microfluidic T-form Mixer Perturbed by Hydrodynamic Pressure Journal of Micromechanics and Microengineering : Structures, Devices, and Systems. Mar, 2008 | Pubmed ID: 19177174 Uropathogens and Host Characteristics Journal of Clinical Microbiology. Dec, 2008 | Pubmed ID: 18842936 Optimal Probe Length and Target Location for Electrochemical Detection of Selected Uropathogens at Ambient Temperature Journal of Clinical Microbiology. Aug, 2008 | Pubmed ID: 18562584 Rapid Antimicrobial Susceptibility Determination of Uropathogens in Clinical Urine Specimens by Use of ATP Bioluminescence Journal of Clinical Microbiology. Apr, 2008 | Pubmed ID: 18272708 Early Diagnosis of Leptospirosis by Immunoglobulin M Immunoblot Testing Clinical and Vaccine Immunology : CVI. Mar, 2008 | Pubmed ID: 18184827 Leptospira Interrogans Endostatin-like Outer Membrane Proteins Bind Host Fibronectin, Laminin and Regulators of Complement PloS One. 2007 | Pubmed ID: 18000555 The Terminal Portion of Leptospiral Immunoglobulin-like Protein LigA Confers Protective Immunity Against Lethal Infection in the Hamster Model of Leptospirosis Vaccine. Aug, 2007 | Pubmed ID: 17629368 Development of an Advanced Electrochemical DNA Biosensor for Bacterial Pathogen Detection The Journal of Molecular Diagnostics : JMD. Apr, 2007 | Pubmed ID: 17384207 Response of Leptospira Interrogans to Physiologic Osmolarity: Relevance in Signaling the Environment-to-host Transition Infection and Immunity. Jun, 2007 | Pubmed ID: 17371863 Leptospira Immunoglobulin-like Proteins As a Serodiagnostic Marker for Acute Leptospirosis Journal of Clinical Microbiology. May, 2007 | Pubmed ID: 17360842 Physiological Osmotic Induction of Leptospira Interrogans Adhesion: LigA and LigB Bind Extracellular Matrix Proteins and Fibrinogen Infection and Immunity. May, 2007 | Pubmed ID: 17296754 Hamster Model of Leptospirosis Current Protocols in Microbiology. Sep, 2006 | Pubmed ID: 18770576 LipL46 is a Novel Surface-exposed Lipoprotein Expressed During Leptospiral Dissemination in the Mammalian Host Microbiology (Reading, England). Dec, 2006 | Pubmed ID: 17159228 Effects of Temperature on Gene Expression Patterns in Leptospira Interrogans Serovar Lai As Assessed by Whole-genome Microarrays Infection and Immunity. Oct, 2006 | Pubmed ID: 16988264 Molecular Epidemiology of Leptospirosis in the Amazon PLoS Medicine. Aug, 2006 | Pubmed ID: 16933961 Use of Electrochemical DNA Biosensors for Rapid Molecular Identification of Uropathogens in Clinical Urine Specimens Journal of Clinical Microbiology. Feb, 2006 | Pubmed ID: 16455913 Lipoprotein Computational Prediction in Spirochaetal Genomes Microbiology (Reading, England). Jan, 2006 | Pubmed ID: 16385121 [Expression in Escherichia Coli of the Gspd(l) Gene of the Type II Secretion System in Leptospira Borgpetersenii Serovariety Hardjo] Revista Cubana De Medicina Tropical. Jan-Apr, 2005 | Pubmed ID: 17966476 LruA and LruB, Novel Lipoproteins of Pathogenic Leptospira Interrogans Associated with Equine Recurrent Uveitis Infection and Immunity. Nov, 2005 | Pubmed ID: 16239521 Leptospirosis After Recreational Exposure to Water in the Yaeyama Islands, Japan The American Journal of Tropical Medicine and Hygiene. Oct, 2005 | Pubmed ID: 16222003 Electrochemical Molecular Analysis Without Nucleic Acid Amplification Methods (San Diego, Calif.). Sep, 2005 | Pubmed ID: 16213156 Surfaceome of Leptospira Spp Infection and Immunity. Aug, 2005 | Pubmed ID: 16040999 Leptospiral Membrane Proteins--variations on a Theme? The Indian Journal of Medical Research. Mar, 2005 | Pubmed ID: 15802754 Diagnostic and Therapeutic Pitfalls Associated with Primaquine-tolerant Plasmodium Vivax Journal of Clinical Microbiology. Feb, 2005 | Pubmed ID: 15695723 Rapid, Species-specific Detection of Uropathogen 16S RDNA and RRNA at Ambient Temperature by Dot-blot Hybridization and an Electrochemical Sensor Array Molecular Genetics and Metabolism. Jan, 2005 | Pubmed ID: 15639199 Osmolarity, a Key Environmental Signal Controlling Expression of Leptospiral Proteins LigA and LigB and the Extracellular Release of LigA Infection and Immunity. Jan, 2005 | Pubmed ID: 15618142 Outer Membrane Proteins of Pathogenic Spirochetes FEMS Microbiology Reviews. Jun, 2004 | Pubmed ID: 15449605 Cell Aggregation: a Mechanism of Pathogenic Leptospira to Survive in Fresh Water International Microbiology : the Official Journal of the Spanish Society for Microbiology. Mar, 2004 | Pubmed ID: 15179605 Molecular Evolution and Mosaicism of Leptospiral Outer Membrane Proteins Involves Horizontal DNA Transfer Journal of Bacteriology. May, 2004 | Pubmed ID: 15090524 Pathogenic Leptospira Species Express Surface-exposed Proteins Belonging to the Bacterial Immunoglobulin Superfamily Molecular Microbiology. Aug, 2003 | Pubmed ID: 12890019 LipL21 is a Novel Surface-exposed Lipoprotein of Pathogenic Leptospira Species Infection and Immunity. May, 2003 | Pubmed ID: 12704111 An Improved Immunohistochemical Diagnostic Technique for Canine Leptospirosis Using Antileptospiral Antibodies on Renal Tissue Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. Jan, 2002 | Pubmed ID: 12680639 Characterization of the Leptospiral Outer Membrane and Description of Three Novel Leptospiral Membrane Proteins Infection and Immunity. Sep, 2002 | Pubmed ID: 12183539 Gastrointestinal Microflora Studies in Late-onset Autism Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Sep, 2002 | Pubmed ID: 12173102 Global Analysis of Outer Membrane Proteins from Leptospira Interrogans Serovar Lai Infection and Immunity. May, 2002 | Pubmed ID: 11953365 Leptospirosis, Water Sports, and Chemoprophylaxis Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. May, 2002 | Pubmed ID: 11941571 Novel 45-kilodalton Leptospiral Protein That is Processed to a 31-kilodalton Growth-phase-regulated Peripheral Membrane Protein Infection and Immunity. Jan, 2002 | Pubmed ID: 11748198 Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins Marija Pinne1,2, David Haake3,4 1Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 2Research service, 151, Veterans Affairs Greater Los Angeles Healthcare System, 3Departments of Medicine, Urology at David Geffen School of Medicine and Department of Microbiology, Immunology and Molecular Gentics, University of California Los Angeles (UCLA), 4Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Health Care System JoVE 2805 免疫与感染
Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins Marija Pinne1,2, David Haake3,4 1Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 2Research service, 151, Veterans Affairs Greater Los Angeles Healthcare System, 3Departments of Medicine, Urology at David Geffen School of Medicine and Department of Microbiology, Immunology and Molecular Gentics, University of California Los Angeles (UCLA), 4Division of Infectious Diseases, 111F, Veterans Affairs Greater Los Angeles Health Care System JoVE 2805 免疫与感染