Douglas R. Seals Department of Integrative Physiology University of Colorado, Boulder Biography Publications Institution JoVE Articles Douglas R. Seals has not added a biography. If you are Douglas R. Seals and would like to personalize this page please email our Author Liaison for assistance. Publications 2013 APS Edward F. Adolph Distinguished Lecture The Remarkable Anti-Aging Effects of Aerobic Exercise on Systemic Arteries Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2014 | Pubmed ID: 24855137 Mitochondria-targeted Antioxidant (MitoQ) Ameliorates Age-related Arterial Endothelial Dysfunction in Mice The Journal of Physiology. Apr, 2014 | Pubmed ID: 24665093 Inorganic Nitrite Supplementation for Healthy Arterial Aging Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2014 | Pubmed ID: 24408999 Superoxide Signaling in Perivascular Adipose Tissue Promotes Age-related Artery Stiffness Aging Cell. Jun, 2014 | Pubmed ID: 24341314 Vascular Endothelial Function and Oxidative Stress Are Related to Dietary Niacin Intake Among Healthy Middle-aged and Older Adults Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2014 | Pubmed ID: 24311750 Battery of Behavioral Tests in Mice That Models Age-associated Changes in Human Motor Function Age (Dordrecht, Netherlands). Apr, 2014 | Pubmed ID: 24122289 Essential Role of Estrogen for Improvements in Vascular Endothelial Function with Endurance Exercise in Postmenopausal Women The Journal of Clinical Endocrinology and Metabolism. Nov, 2013 | Pubmed ID: 24092827 Aging Compounds Western Diet-associated Large Artery Endothelial Dysfunction in Mice: Prevention by Voluntary Aerobic Exercise Experimental Gerontology. Nov, 2013 | Pubmed ID: 23954368 Dietary Sodium Restriction and Association with Urinary Marinobufagenin, Blood Pressure, and Aortic Stiffness Clinical Journal of the American Society of Nephrology : CJASN. Nov, 2013 | Pubmed ID: 23929930 Activation of the Unfolded Protein Response in Vascular Endothelial Cells of Nondiabetic Obese Adults The Journal of Clinical Endocrinology and Metabolism. Sep, 2013 | Pubmed ID: 23913943 Response to Effect of Fenofibrate on Vascular Endothelial Function: Statistical Appraisal and Its Validity Hypertension. Jun, 2013 | Pubmed ID: 23819148 Translational Physiology: from Molecules to Public Health The Journal of Physiology. Jul, 2013 | Pubmed ID: 23732641 Life-long Caloric Restriction Reduces Oxidative Stress and Preserves Nitric Oxide Bioavailability and Function in Arteries of Old Mice Aging Cell. Oct, 2013 | Pubmed ID: 23714110 Aortic Pulse Wave Velocity and Reflecting Distance Estimation from Peripheral Waveforms in Humans: Detection of Age- and Exercise Training-Related Differences American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2013 | Pubmed ID: 23624628 The Autophagy Enhancer Spermidine Reverses Arterial Aging Mechanisms of Ageing and Development. Jul-Aug, 2013 | Pubmed ID: 23612189 The Dependence of FMD% on Baseline Diameter: a Problem Solved by Allometric Scaling - No Problem in This Case Clinical Science (London, England : 1979). Jul, 2013 | Pubmed ID: 23368887 Curcumin Ameliorates Arterial Dysfunction and Oxidative Stress with Aging Experimental Gerontology. Feb, 2013 | Pubmed ID: 23142245 Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-aged/older Adults with Moderately Elevated Systolic Blood Pressure Journal of the American College of Cardiology. Jan, 2013 | Pubmed ID: 23141486 Regular Aerobic Exercise Protects Against Impaired Fasting Plasma Glucose-associated Vascular Endothelial Dysfunction with Aging Clinical Science (London, England : 1979). Mar, 2013 | Pubmed ID: 23025811 Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing Endothelial Nitric Oxide Synthase in Healthy Normolipidemic Older Adults Hypertension. Dec, 2012 | Pubmed ID: 23108655 Vascular Smooth Muscle Responsiveness to Nitric Oxide is Reduced in Healthy Adults with Increased Adiposity American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2012 | Pubmed ID: 22821988 Hysterectomy is Associated with Large Artery Stiffening in Estrogen-deficient Postmenopausal Women Menopause (New York, N.Y.). Sep, 2012 | Pubmed ID: 22692329 Tetrahydrobiopterin Supplementation Enhances Carotid Artery Compliance in Healthy Older Men: a Pilot Study American Journal of Hypertension. Oct, 2012 | Pubmed ID: 22673017 Sodium Nitrite De-stiffening of Large Elastic Arteries with Aging: Role of Normalization of Advanced Glycation End-products Experimental Gerontology. Aug, 2012 | Pubmed ID: 22588062 Translational Evidence That Impaired Autophagy Contributes to Arterial Ageing The Journal of Physiology. Jul, 2012 | Pubmed ID: 22570377 Sustained Activation of AMPK Ameliorates Age-associated Vascular Endothelial Dysfunction Via a Nitric Oxide-independent Mechanism Mechanisms of Ageing and Development. May, 2012 | Pubmed ID: 22484146 Vascular Health in the Ageing Athlete Experimental Physiology. Mar, 2012 | Pubmed ID: 22266948 Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults American Journal of Hypertension. Jan, 2012 | Pubmed ID: 22237152 Superoxide-lowering Therapy with TEMPOL Reverses Arterial Dysfunction with Aging in Mice Aging Cell. Apr, 2012 | Pubmed ID: 22168264 MicroRNA Changes in Human Arterial Endothelial Cells with Senescence: Relation to Apoptosis, ENOS and Inflammation Experimental Gerontology. Jan, 2012 | Pubmed ID: 22037549 Replicative Aging Induces Endothelial to Mesenchymal Transition in Human Aortic Endothelial Cells: Potential Role of Inflammation Journal of Vascular Research. 2012 | Pubmed ID: 21985896 Habitually Exercising Older Men Do Not Demonstrate Age-associated Vascular Endothelial Oxidative Stress Aging Cell. Dec, 2011 | Pubmed ID: 21943306 Plasma Norepinephrine is an Independent Predictor of Vascular Endothelial Function with Aging in Healthy Women Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2011 | Pubmed ID: 21903879 SIRT-1 and Vascular Endothelial Dysfunction with Ageing in Mice and Humans The Journal of Physiology. Sep, 2011 | Pubmed ID: 21746786 Aerobic Exercise Reverses Arterial Inflammation with Aging in Mice American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2011 | Pubmed ID: 21622824 Increased Proinflammatory and Oxidant Gene Expression in Circulating Mononuclear Cells in Older Adults: Amelioration by Habitual Exercise Physiological Genomics. Jul, 2011 | Pubmed ID: 21610086 Exercise Protects Against Myocardial Ischemia-reperfusion Injury Via Stimulation of β(3)-adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols Circulation Research. Jun, 2011 | Pubmed ID: 21527738 Salicylate Treatment Improves Age-associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor KappaB and Forkhead Box O Phosphorylation The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Apr, 2011 | Pubmed ID: 21303813 Nitrite Supplementation Reverses Vascular Endothelial Dysfunction and Large Elastic Artery Stiffness with Aging Aging Cell. Jun, 2011 | Pubmed ID: 21276184 Aging and Vascular Endothelial Function in Humans Clinical Science (London, England : 1979). May, 2011 | Pubmed ID: 21244363 The Importance of Population-wide Sodium Reduction As a Means to Prevent Cardiovascular Disease and Stroke: a Call to Action from the American Heart Association Circulation. Mar, 2011 | Pubmed ID: 21233236 25-Hydroxyvitamin D Deficiency is Associated with Inflammation-linked Vascular Endothelial Dysfunction in Middle-aged and Older Adults Hypertension. Jan, 2011 | Pubmed ID: 21115878 Sex-specific Effects of Habitual Aerobic Exercise on Brachial Artery Flow-mediated Dilation in Middle-aged and Older Adults Clinical Science (London, England : 1979). Jan, 2011 | Pubmed ID: 20642454 Life-long Caloric Restriction Elicits Pronounced Protection of the Aged Myocardium: a Role for AMPK Mechanisms of Ageing and Development. Nov-Dec, 2010 | Pubmed ID: 20934448 Arterial Stiffening with Ageing is Associated with Transforming Growth Factor-β1-related Changes in Adventitial Collagen: Reversal by Aerobic Exercise The Journal of Physiology. Oct, 2010 | Pubmed ID: 20807791 Leukocyte Telomere Length is Preserved with Aging in Endurance Exercise-trained Adults and Related to Maximal Aerobic Capacity Mechanisms of Ageing and Development. Feb, 2010 | Pubmed ID: 20064545 Vascular Endothelial Function is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-aged and Older Adults Hypertension. Feb, 2010 | Pubmed ID: 20048194 Protein Expression in Vascular Endothelial Cells Obtained from Human Peripheral Arteries and Veins Journal of Vascular Research. 2010 | Pubmed ID: 19672102 Role of NFkappaB in Age-related Vascular Endothelial Dysfunction in Humans Aging. Aug, 2009 | Pubmed ID: 20157550 Low Dietary Sodium Intake is Associated with Enhanced Vascular Endothelial Function in Middle-aged and Older Adults with Elevated Systolic Blood Pressure Therapeutic Advances in Cardiovascular Disease. Oct, 2009 | Pubmed ID: 19723834 Habitual Exercise and Vascular Ageing The Journal of Physiology. Dec, 2009 | Pubmed ID: 19723776 Vascular Endothelial Estrogen Receptor Alpha is Modulated by Estrogen Status and Related to Endothelial Function and Endothelial Nitric Oxide Synthase in Healthy Women The Journal of Clinical Endocrinology and Metabolism. Sep, 2009 | Pubmed ID: 19509105 Vascular Endothelial Dysfunction with Aging: Endothelin-1 and Endothelial Nitric Oxide Synthase American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2009 | Pubmed ID: 19465546 Voluntary Wheel Running Restores Endothelial Function in Conduit Arteries of Old Mice: Direct Evidence for Reduced Oxidative Stress, Increased Superoxide Dismutase Activity and Down-regulation of NADPH Oxidase The Journal of Physiology. Jul, 2009 | Pubmed ID: 19417091 Nuclear Factor-{kappa}B Activation Contributes to Vascular Endothelial Dysfunction Via Oxidative Stress in Overweight/obese Middle-aged and Older Humans Circulation. Mar, 2009 | Pubmed ID: 19237660 B6D2F1 Mice Are a Suitable Model of Oxidative Stress-mediated Impaired Endothelium-dependent Dilation with Aging The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2009 | Pubmed ID: 19211548 Modulation of Vascular Endothelial Function by Low-density Lipoprotein Cholesterol with Aging: Influence of Habitual Exercise American Journal of Hypertension. Mar, 2009 | Pubmed ID: 19114985 Aging is Associated with Greater Nuclear NF Kappa B, Reduced I Kappa B Alpha, and Increased Expression of Proinflammatory Cytokines in Vascular Endothelial Cells of Healthy Humans Aging Cell. Dec, 2008 | Pubmed ID: 18782346 Cytochrome P-450 2C9 Signaling Does Not Contribute to Age-associated Vascular Endothelial Dysfunction in Humans Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2008 | Pubmed ID: 18669935 Habitual Exercise and Arterial Aging Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2008 | Pubmed ID: 18583377 Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/obese Adults Hypertension. Jul, 2008 | Pubmed ID: 18504322 Decreased Maximal Heart Rate with Aging is Related to Reduced {beta}-adrenergic Responsiveness but is Largely Explained by a Reduction in Intrinsic Heart Rate Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2008 | Pubmed ID: 18483165 Endurance Exercise Performance in Masters Athletes: Age-associated Changes and Underlying Physiological Mechanisms The Journal of Physiology. Jan, 2008 | Pubmed ID: 17717011 High-dose Ascorbic Acid Infusion Abolishes Chronic Vasoconstriction and Restores Resting Leg Blood Flow in Healthy Older Men Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2007 | Pubmed ID: 17965239 Increased Thermogenic Responsiveness to Intravenous Beta-adrenergic Stimulation in Habitually Exercising Humans is Not Related to Skeletal Muscle Beta2-adrenergic Receptor Density Experimental Physiology. Sep, 2007 | Pubmed ID: 17573413 Direct Evidence of Endothelial Oxidative Stress with Aging in Humans: Relation to Impaired Endothelium-dependent Dilation and Upregulation of Nuclear Factor-kappaB Circulation Research. Jun, 2007 | Pubmed ID: 17478731 Thermic Effect of Food and Beta-adrenergic Thermogenic Responsiveness in Habitually Exercising and Sedentary Healthy Adult Humans Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2007 | Pubmed ID: 17463294 Commentary on Viewpoint "Human Experimentation: No Accurate, Quantitative Data?" Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2007 | Pubmed ID: 17341743 Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47(phox) Expression and Evidence of Endothelial Oxidative Stress Circulation. Feb, 2007 | Pubmed ID: 17242275 A Transdisciplinary Model Integrating Genetic, Physiological, and Psychological Correlates of Voluntary Exercise Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association. Jan, 2007 | Pubmed ID: 17209695 Oxidative Stress Contributes to Chronic Leg Vasoconstriction in Estrogen-deficient Postmenopausal Women Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2007 | Pubmed ID: 17110511 Impaired Flow-mediated Dilation with Age is Not Explained by L-arginine Bioavailability or Endothelial Asymmetric Dimethylarginine Protein Expression Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2007 | Pubmed ID: 16946027 Habitual Aerobic Exercise is Associated with Smaller Femoral Artery Intima-media Thickness with Age in Healthy Men and Women European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. Oct, 2006 | Pubmed ID: 17001222 Oxidative Stress Explains Differences in Large Elastic Artery Compliance Between Sedentary and Habitually Exercising Postmenopausal Women Menopause (New York, N.Y.). Nov-Dec, 2006 | Pubmed ID: 16977254 Modulatory Influences on Ageing of the Vasculature in Healthy Humans Experimental Gerontology. May, 2006 | Pubmed ID: 16537099 Xanthine Oxidase Does Not Contribute to Impaired Peripheral Conduit Artery Endothelium-dependent Dilatation with Ageing The Journal of Physiology. Mar, 2006 | Pubmed ID: 16439428 Cardiac Vagal Modulation of Heart Rate During Prolonged Submaximal Exercise in Animals with Healed Myocardial Infarctions: Effects of Training American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2006 | Pubmed ID: 16339826 Thermogenic Responsiveness to Beta-adrenergic Stimulation is Augmented in Exercising Versus Sedentary Adults: Role of Oxidative Stress The Journal of Physiology. Feb, 2006 | Pubmed ID: 16308351 Thermogenic Responsiveness to Nonspecific Beta-adrenergic Stimulation is Not Related to Genetic Variation in Codon 16 of the Beta2-adrenergic Receptor American Journal of Physiology. Endocrinology and Metabolism. Apr, 2006 | Pubmed ID: 16278251 Tetrahydrobiopterin Augments Endothelium-dependent Dilatation in Sedentary but Not in Habitually Exercising Older Adults The Journal of Physiology. Nov, 2005 | Pubmed ID: 16141271 Aortic Input Impedance Increases with Age in Healthy Men and Women Hypertension. Jun, 2005 | Pubmed ID: 15867143 Ascorbic Acid Selectively Improves Large Elastic Artery Compliance in Postmenopausal Women Hypertension. Jun, 2005 | Pubmed ID: 15867135 Fatness is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men Circulation. Apr, 2005 | Pubmed ID: 15837943 Women Have Lower Tonic Autonomic Support of Arterial Blood Pressure and Less Effective Baroreflex Buffering Than Men Circulation. Feb, 2005 | Pubmed ID: 15687139 Stiffening Our Resolve Against Adult Weight Gain Hypertension. Feb, 2005 | Pubmed ID: 15623541 Ascorbic Acid Does Not Affect the Age-associated Reduction in Maximal Cardiac Output and Oxygen Consumption in Healthy Adults Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2005 | Pubmed ID: 15501926 Collateral Damage: Cardiovascular Consequences of Chronic Sympathetic Activation with Human Aging American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2004 | Pubmed ID: 15475526 Role of Sympathetic Neural Activation in Age- and Habitual Exercise-related Differences in the Thermic Effect of Food The Journal of Clinical Endocrinology and Metabolism. Oct, 2004 | Pubmed ID: 15472218 High Energy Flux Mediates the Tonically Augmented Beta-adrenergic Support of Resting Metabolic Rate in Habitually Exercising Older Adults The Journal of Clinical Endocrinology and Metabolism. Jul, 2004 | Pubmed ID: 15240648 Increased Abdominal-to-peripheral Fat Distribution Contributes to Altered Autonomic-circulatory Control with Human Aging American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2004 | Pubmed ID: 15178547 Dietary Sodium Restriction Rapidly Improves Large Elastic Artery Compliance in Older Adults with Systolic Hypertension Hypertension. Jul, 2004 | Pubmed ID: 15173128 Ascorbic Acid Does Not Affect Large Elastic Artery Compliance or Central Blood Pressure in Young and Older Men American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2004 | Pubmed ID: 15020306 Ascorbic Acid Increases Cardiovagal Baroreflex Sensitivity in Healthy Older Men American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2004 | Pubmed ID: 14962830 Effect of Acute and Chronic Ascorbic Acid on Flow-mediated Dilatation with Sedentary and Physically Active Human Ageing The Journal of Physiology. Apr, 2004 | Pubmed ID: 14754992 Chronic Sympathetic Activation: Consequence and Cause of Age-associated Obesity? Diabetes. Feb, 2004 | Pubmed ID: 14747276 Left Ventricular Structure and Diastolic Function with Human Ageing. Relation to Habitual Exercise and Arterial Stiffness European Heart Journal. Dec, 2003 | Pubmed ID: 14659773 Oxidative Stress Does Not Modulate Metabolic Rate or Skeletal Muscle Sympathetic Activity with Primary Aging in Adult Humans The Journal of Clinical Endocrinology and Metabolism. Oct, 2003 | Pubmed ID: 14557479 Adiposity Contributes to Differences in Left Ventricular Structure and Diastolic Function with Age in Healthy Men The Journal of Clinical Endocrinology and Metabolism. Oct, 2003 | Pubmed ID: 14557469 Invited Review: Dynamic Exercise Performance in Masters Athletes: Insight into the Effects of Primary Human Aging on Physiological Functional Capacity Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2003 | Pubmed ID: 14555676 Baroreflex Buffering in Sedentary and Endurance Exercise-trained Healthy Men Hypertension. Jun, 2003 | Pubmed ID: 12732585 Habitual Exercise and the Age-associated Decline in Large Artery Compliance Exercise and Sport Sciences Reviews. Apr, 2003 | Pubmed ID: 12715969 Baroreflex Buffering is Reduced with Age in Healthy Men Circulation. Apr, 2003 | Pubmed ID: 12665501 Regular Exercise, Hormone Replacement Therapy and the Age-related Decline in Carotid Arterial Compliance in Healthy Women Cardiovascular Research. Mar, 2003 | Pubmed ID: 12618248 Basal Leg Blood Flow in Healthy Women is Related to Age and Hormone Replacement Therapy Status The Journal of Physiology. Feb, 2003 | Pubmed ID: 12562958 Use of Acetylene Breathing to Determine Cardiac Output in Young and Older Adults Medicine and Science in Sports and Exercise. Jan, 2003 | Pubmed ID: 12544636 Greater Rate of Decline in Maximal Aerobic Capacity with Age in Endurance-trained Than in Sedentary Men Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2003 | Pubmed ID: 12533496 Declines in Physiological Functional Capacity with Age: a Longitudinal Study in Peak Swimming Performance Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2003 | Pubmed ID: 12391125 Decline in Insulin Action with Age in Endurance-trained Humans Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2002 | Pubmed ID: 12391128 Arterial Intima-media Thickness: Site-specific Associations with HRT and Habitual Exercise American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2002 | Pubmed ID: 12234791 Changes in Maximal Aerobic Capacity with Age in Endurance-trained Women: 7-yr Follow-up Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2002 | Pubmed ID: 12015340 Influence of Ageing on the Sympathetic Nervous System and Adrenal Medulla at Rest and During Stress Biogerontology. 2002 | Pubmed ID: 12014841 Is Autonomic Support of Arterial Blood Pressure Related to Habitual Exercise Status in Healthy Men? The Journal of Physiology. Apr, 2002 | Pubmed ID: 11956356 Regular Aerobic Exercise and the Age-related Increase in Carotid Artery Intima-media Thickness in Healthy Men Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2002 | Pubmed ID: 11896010 The Influence of Aging on the Human Sympathetic Nervous System and Brain Norepinephrine Turnover American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2002 | Pubmed ID: 11832414 Assessment of Vascular Function in Patients With Chronic Kidney Disease Kristen L. Jablonski1, Emily Decker1, Loni Perrenoud1, Jessica Kendrick1, Michel Chonchol1, Douglas R. Seals2, Diana Jalal1 1Division of Renal Diseases and Hypertension, University of Colorado, Denver, 2Department of Integrative Physiology, University of Colorado, Boulder JoVE 51478 医学
Assessment of Vascular Function in Patients With Chronic Kidney Disease Kristen L. Jablonski1, Emily Decker1, Loni Perrenoud1, Jessica Kendrick1, Michel Chonchol1, Douglas R. Seals2, Diana Jalal1 1Division of Renal Diseases and Hypertension, University of Colorado, Denver, 2Department of Integrative Physiology, University of Colorado, Boulder JoVE 51478 医学