Herbert Gaisano Department of Medicine University of Toronto Biography Publications Institution JoVE Articles Herbert Gaisano has not added a biography. If you are Herbert Gaisano and would like to personalize this page please email our Author Liaison for assistance. Publications Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction Diabetes. Jul, 2017 | Pubmed ID: 28607108 The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1 Diabetes. Sep, 2017 | Pubmed ID: 28596237 Association Between Indices of Body Composition and Abnormal Metabolic Phenotype in Normal-Weight Chinese Adults International Journal of Environmental Research and Public Health. Apr, 2017 | Pubmed ID: 28387701 Ex Vivo Human Pancreatic Slice Preparations Offer a Valuable Model for Studying Pancreatic Exocrine Biology The Journal of Biological Chemistry. Apr, 2017 | Pubmed ID: 28242761 Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis EBioMedicine. Feb, 2017 | Pubmed ID: 28163042 Syntaxin 2 Acts As Inhibitory SNARE for Insulin Granule Exocytosis Diabetes. Apr, 2017 | Pubmed ID: 28115395 Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Journal of the American Heart Association. Jan, 2017 | Pubmed ID: 28108466 Palmitic Acid Increases Invasiveness of Pancreatic Cancer Cells AsPC-1 Through TLR4/ROS/NF-κB/MMP-9 Signaling Pathway Biochemical and Biophysical Research Communications. Feb, 2017 | Pubmed ID: 28088520 New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment The Journal of Biological Chemistry. Feb, 2017 | Pubmed ID: 28031464 Cell Polarity Defines Three Distinct Domains in Pancreatic β-cells Journal of Cell Science. Jan, 2017 | Pubmed ID: 26919978 Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells Diabetes. Jul, 2016 | Pubmed ID: 27207520 Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study PloS One. 2016 | Pubmed ID: 27070309 Changes in Beta Cell Function Occur in Prediabetes and Early Disease in the Lepr (db) Mouse Model of Diabetes Diabetologia. Jun, 2016 | Pubmed ID: 27048248 Syntaxin-3 Binds and Regulates Both R- and L-Type Calcium Channels in Insulin-Secreting INS-1 832/13 Cells PloS One. 2016 | Pubmed ID: 26848587 Erratum To: Association of KCNB1 Polymorphisms with Lipid Metabolisms and Insulin Resistance: a Case-control Design of Population-based Cross-sectional Study in Chinese Han Population Lipids in Health and Disease. Nov, 2015 | Pubmed ID: 26545729 Cell-to-Cell Communication and the Regulation of Pancreatic Function Pancreas. Nov, 2015 | Pubmed ID: 26465945 Association of KCNB1 Polymorphisms with Lipid Metabolisms and Insulin Resistance: a Case-control Design of Population-based Cross-sectional Study in Chinese Han Population Lipids in Health and Disease. Sep, 2015 | Pubmed ID: 26377690 Spatial and Temporal Coordination of Insulin Granule Exocytosis in Intact Human Pancreatic Islets Diabetologia. Dec, 2015 | Pubmed ID: 26376795 A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26272612 ER Stress-associated CTRC Mutants Decrease Stimulated Pancreatic Zymogen Secretion Through SIRT2-mediated Microtubule Dysregulation Biochemical and Biophysical Research Communications. Jul, 2015 | Pubmed ID: 26022124 Munc18c Mediates Exocytosis of Pre-docked and Newcomer Insulin Granules Underlying Biphasic Glucose Stimulated Insulin Secretion in Human Pancreatic Beta-cells Molecular Metabolism. May, 2015 | Pubmed ID: 25973389 Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 25969539 The Expression of Dominant Negative TCF7L2 in Pancreatic Beta Cells During the Embryonic Stage Causes Impaired Glucose Homeostasis Molecular Metabolism. Apr, 2015 | Pubmed ID: 25830097 Chaperoning of Closed Syntaxin-3 Through Lys46 and Glu59 in Domain 1 of Munc18 Proteins is Indispensable for Mast Cell Exocytosis Journal of Cell Science. May, 2015 | Pubmed ID: 25795302 Syntaxin-4 Mediates Exocytosis of Pre-docked and Newcomer Insulin Granules Underlying Biphasic Glucose-stimulated Insulin Secretion in Human Pancreatic Beta Cells Diabetologia. Jun, 2015 | Pubmed ID: 25762204 PTEN Deletion in Pancreatic α-cells Protects Against High-fat Diet-induced Hyperglucagonemia and Insulin Resistance Diabetes. Jan, 2015 | Pubmed ID: 25092678 Vesicle Associated Membrane Protein 8 (VAMP8)-mediated Zymogen Granule Exocytosis is Dependent on Endosomal Trafficking Via the Constitutive-like Secretory Pathway The Journal of Biological Chemistry. Oct, 2014 | Pubmed ID: 25138214 Phosphatidylinositol 4,5-biphosphate (PIP2) Modulates Syntaxin-1A Binding to Sulfonylurea Receptor 2A to Regulate Cardiac ATP-sensitive Potassium (KATP) Channels Journal of Molecular and Cellular Cardiology. Oct, 2014 | Pubmed ID: 25073062 Progesterone Receptor Membrane Component 1 is a Functional Part of the Glucagon-like Peptide-1 (GLP-1) Receptor Complex in Pancreatic β Cells Molecular & Cellular Proteomics : MCP. Nov, 2014 | Pubmed ID: 25044020 Dichotomous Role of Pancreatic HUWE1/MULE/ARF-BP1 in Modulating Beta Cell Apoptosis in Mice Under Physiological and Genotoxic Conditions Diabetologia. Sep, 2014 | Pubmed ID: 24981769 α/β-Hydrolase Domain-6-accessible Monoacylglycerol Controls Glucose-stimulated Insulin Secretion Cell Metabolism. Jun, 2014 | Pubmed ID: 24814481 Insulin Secretion from Beta Cells in Intact Mouse Islets is Targeted Towards the Vasculature Diabetologia. Aug, 2014 | Pubmed ID: 24795086 Here Come the Newcomer Granules, Better Late Than Never Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24746186 The Secretory Deficit in Islets from Db/db Mice is Mainly Due to a Loss of Responding Beta Cells Diabetologia. Jul, 2014 | Pubmed ID: 24705605 Biliopancreatic Route for Effective Viral Transduction of Pancreatic Islets Pancreas. Mar, 2014 | Pubmed ID: 24518502 Phosphatidylinositol 4,5-biphosphate (PIP2) Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-cell ATP-sensitive Potassium Channels The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24429282 Role of Vesicle-associated Membrane Protein 2 in Exocytosis of Glucagon-like Peptide-1 from the Murine Intestinal L Cell Diabetologia. Apr, 2014 | Pubmed ID: 24356748 Glucose Principally Regulates Insulin Secretion in Mouse Islets by Controlling the Numbers of Granule Fusion Events Per Cell Diabetologia. Dec, 2013 | Pubmed ID: 23995471 Exocyst Sec5 Regulates Exocytosis of Newcomer Insulin Granules Underlying Biphasic Insulin Secretion PloS One. 2013 | Pubmed ID: 23844030 Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats Diabetes. Aug, 2013 | Pubmed ID: 23630299 UCP2 Regulates the Glucagon Response to Fasting and Starvation Diabetes. May, 2013 | Pubmed ID: 23434936 An Exploratory Study of the Association Between KCNB1 Rs1051295 and Type 2 Diabetes and Its Related Traits in Chinese Han Population PloS One. 2013 | Pubmed ID: 23431371 Munc18b is a Major Mediator of Insulin Exocytosis in Rat Pancreatic β-cells Diabetes. Jul, 2013 | Pubmed ID: 23423569 RalA GTPase Tethers Insulin Granules to L- and R-type Calcium Channels Through Binding α2 δ-1 Subunit Traffic (Copenhagen, Denmark). Apr, 2013 | Pubmed ID: 23346930 Role of the SNARE Protein SNAP23 on CAMP-stimulated Renin Release in Mouse Juxtaglomerular Cells American Journal of Physiology. Renal Physiology. Mar, 2013 | Pubmed ID: 23269646 In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion Diabetes. Feb, 2013 | Pubmed ID: 23043159 Glucagon Secretion and Signaling in the Development of Diabetes Frontiers in Physiology. 2012 | Pubmed ID: 22969729 Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth Cell Metabolism. Jul, 2012 | Pubmed ID: 22841572 Effects of Ethanol Metabolites on Exocytosis of Pancreatic Acinar Cells in Rats Gastroenterology. Jun, 2012 | Pubmed ID: 22710192 In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking Diabetes. Jul, 2012 | Pubmed ID: 22498697 Molecular Control of Compound Exocytosis: A Key Role for VAMP8 Communicative & Integrative Biology. Jan, 2012 | Pubmed ID: 22482012 Pancreatic GLP-1 Receptor Activation is Sufficient for Incretin Control of Glucose Metabolism in Mice The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22182839 Syntaxin-1A Inhibits KATP Channels by Interacting with Specific Conserved Motifs Within Sulfonylurea Receptor 2A Journal of Molecular and Cellular Cardiology. Nov, 2011 | Pubmed ID: 21884702 Vesicle-associated Membrane Protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21733851 Electrophysiological Identification of Mouse Islet α-cells: from Isolated Single α-cells to in Situ Assessment Within Pancreas Slices Islets. Jul-Aug, 2011 | Pubmed ID: 21623173 Syntaxin-1A Interacts with Distinct Domains Within Nucleotide-binding Folds of Sulfonylurea Receptor 1 to Inhibit Beta-cell ATP-sensitive Potassium Channels The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21540180 Live Pancreatic Acinar Imaging of Exocytosis Using Syncollin-pHluorin American Journal of Physiology. Cell Physiology. Jun, 2011 | Pubmed ID: 21307342 SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans Diabetes. Mar, 2011 | Pubmed ID: 21266332 TGF-β1 Increases Invasiveness of SW1990 Cells Through Rac1/ROS/NF-κB/IL-6/MMP-2 Biochemical and Biophysical Research Communications. Feb, 2011 | Pubmed ID: 21219858 Syntaxin 1A Regulates Surface Expression of Beta-cell ATP-sensitive Potassium Channels American Journal of Physiology. Cell Physiology. Mar, 2011 | Pubmed ID: 21209369 ATP Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic Beta-cell KATP Channels The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21173146 SNARE Protein Regulation of Cardiac Potassium Channels and Atrial Natriuretic Factor Secretion Journal of Molecular and Cellular Cardiology. Mar, 2011 | Pubmed ID: 21129378 Unperturbed Islet α-cell Function Examined in Mouse Pancreas Tissue Slices The Journal of Physiology. Jan, 2011 | Pubmed ID: 21078586 Nitric Oxide Activation of a Potassium Channel (BK(Ca)) in Feline Lower Esophageal Sphincter World Journal of Gastroenterology. Dec, 2010 | Pubmed ID: 21155007 Erythropoietin Protects Against Diabetes Through Direct Effects on Pancreatic Beta Cells The Journal of Experimental Medicine. Dec, 2010 | Pubmed ID: 21149549 Deletion of Pten in Pancreatic ß-cells Protects Against Deficient ß-cell Mass and Function in Mouse Models of Type 2 Diabetes Diabetes. Dec, 2010 | Pubmed ID: 20852026 Insulin Treatment and High-fat Diet Feeding Reduces the Expression of Three Tcf Genes in Rodent Pancreas The Journal of Endocrinology. Oct, 2010 | Pubmed ID: 20675304 Hypoxia-reoxygenation Increase Invasiveness of PANC-1 Cells Through Rac1/MMP-2 Biochemical and Biophysical Research Communications. Mar, 2010 | Pubmed ID: 20153729 Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction Between Munc18 and Closed Syntaxin in PC12 Cells Molecular Biology of the Cell. Dec, 2009 | Pubmed ID: 19812250 Deletion of Fas in the Pancreatic Beta-cells Leads to Enhanced Insulin Secretion American Journal of Physiology. Endocrinology and Metabolism. Dec, 2009 | Pubmed ID: 19755672 Characterization of Erg K+ Channels in Alpha- and Beta-cells of Mouse and Human Islets The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19690348 Functional Characterization of Hyperpolarization-activated Cyclic Nucleotide-gated Channels in Rat Pancreatic Beta Cells The Journal of Endocrinology. Oct, 2009 | Pubmed ID: 19654142 Proteínas Homeodomain POU Oct-1 Funciona Como Un Sensor De AMP Cíclico The Journal of Biological Chemistry. Sep, 2009 | Pubmed ID: 19617623 Truncation of SNAP-25 Reduces the Stimulatory Action of CAMP on Rapid Exocytosis in Insulin-secreting Cells American Journal of Physiology. Endocrinology and Metabolism. Aug, 2009 | Pubmed ID: 19509185 Cab45b, a Munc18b-interacting Partner, Regulates Exocytosis in Pancreatic Beta-cells The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19487699 New Insights into the Mechanisms of Pancreatitis Gastroenterology. Jun, 2009 | Pubmed ID: 19379751 High Beta-cell Mass Prevents Streptozotocin-induced Diabetes in Thioredoxin-interacting Protein-deficient Mice American Journal of Physiology. Endocrinology and Metabolism. Jun, 2009 | Pubmed ID: 19223654 Rescuing the Subprime Meltdown in Insulin Exocytosis in Diabetes Annals of the New York Academy of Sciences. Jan, 2009 | Pubmed ID: 19161386 Epac is Involved in CAMP-stimulated Proglucagon Expression and Hormone Production but Not Hormone Secretion in Pancreatic Alpha- and Intestinal L-cell Lines American Journal of Physiology. Endocrinology and Metabolism. Jan, 2009 | Pubmed ID: 18854429 Syntaxin-1A Inhibition of P-1075, Cromakalim, and Diazoxide Actions on Mouse Cardiac ATP-sensitive Potassium Channel Cardiovascular Research. Dec, 2008 | Pubmed ID: 18703534 Inhibition of Cholesterol Biosynthesis Impairs Insulin Secretion and Voltage-gated Calcium Channel Function in Pancreatic Beta-cells Endocrinology. Oct, 2008 | Pubmed ID: 18599549 Inhibition of Rac1 Decreases the Severity of Pancreatitis and Pancreatitis-associated Lung Injury in Mice Experimental Physiology. Oct, 2008 | Pubmed ID: 18567599 VAMP8 is the V-SNARE That Mediates Basolateral Exocytosis in a Mouse Model of Alcoholic Pancreatitis The Journal of Clinical Investigation. Jul, 2008 | Pubmed ID: 18535671 Pancreatic Islet Alpha Cell Commands Itself: Secrete More Glucagon! Cell Metabolism. Jun, 2008 | Pubmed ID: 18522828 The RalA GTPase is a Central Regulator of Insulin Exocytosis from Pancreatic Islet Beta Cells The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18426794 Munc18/SNARE Proteins' Regulation of Exocytosis in Guinea Pig Duodenal Brunner's Gland Acini World Journal of Gastroenterology. Apr, 2008 | Pubmed ID: 18416456 Elevation in Intracellular Long-chain Acyl-coenzyme A Esters Lead to Reduced Beta-cell Excitability Via Activation of Adenosine 5'-triphosphate-sensitive Potassium Channels Endocrinology. Jul, 2008 | Pubmed ID: 18372336 Botulinum Neurotoxin A and Neurotoxin E Cleavage Products of Synaptosome-associated Protein of 25 Kd Exhibit Distinct Actions on Pancreatic Islet Beta-cell Kv2.1 Channel Gating Pancreas. Jan, 2008 | Pubmed ID: 18192874 Munc18-1 is Critical for Plasma Membrane Localization of Syntaxin1 but Not of SNAP-25 in PC12 Cells Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18077557 Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-granule Fusions in Rat Islet Beta Cells Pancreas. Oct, 2007 | Pubmed ID: 17895835 SNAREing Voltage-gated K+ and ATP-sensitive K+ Channels: Tuning Beta-cell Excitability with Syntaxin-1A and Other Exocytotic Proteins Endocrine Reviews. Oct, 2007 | Pubmed ID: 17878408 Dynamin is Functionally Coupled to Insulin Granule Exocytosis The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17848579 Interaction of Syntaxin 1A with the N-terminus of Kv4.2 Modulates Channel Surface Expression and Gating Biochemistry. Sep, 2007 | Pubmed ID: 17725325 Interaction Between Munc13-1 and RIM is Critical for Glucagon-like Peptide-1 Mediated Rescue of Exocytotic Defects in Munc13-1 Deficient Pancreatic Beta-cells Diabetes. Oct, 2007 | Pubmed ID: 17639022 Distinct in Vivo Roles of Caspase-8 in Beta-cells in Physiological and Diabetes Models Diabetes. Sep, 2007 | Pubmed ID: 17563067 Ca2+-dependent Activator Protein for Secretion 1 is Critical for Constitutive and Regulated Exocytosis but Not for Loading of Transmitters into Dense Core Vesicles The Journal of Biological Chemistry. Jul, 2007 | Pubmed ID: 17540763 Modulation of the K(v)4.3 Channel by Syntaxin 1A Biochemical and Biophysical Research Communications. Jul, 2007 | Pubmed ID: 17506992 The Actions of a Novel Potent Islet Beta-cell Specific ATP-sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1 Diabetes. Aug, 2007 | Pubmed ID: 17496234 Alcohol Redirects CCK-mediated Apical Exocytosis to the Acinar Basolateral Membrane in Alcoholic Pancreatitis Traffic (Copenhagen, Denmark). May, 2007 | Pubmed ID: 17451559 A Cytosolic Splice Variant of Cab45 Interacts with Munc18b and Impacts on Amylase Secretion by Pancreatic Acini Molecular Biology of the Cell. Jul, 2007 | Pubmed ID: 17442889 Effects of Palmitate on Insulin Secretion and Exocytotic Proteins in Islets of Diabetic Goto-Kakizaki Rats Pancreas. Apr, 2007 | Pubmed ID: 17414060 Alcohol-induced Protein Kinase Calpha Phosphorylation of Munc18c in Carbachol-stimulated Acini Causes Basolateral Exocytosis Gastroenterology. Apr, 2007 | Pubmed ID: 17408632 Alcohol/cholecystokinin-evoked Pancreatic Acinar Basolateral Exocytosis is Mediated by Protein Kinase C Alpha Phosphorylation of Munc18c The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17324928 Targeting of Voltage-gated K+ and Ca2+ Channels and Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor Proteins to Cholesterol-rich Lipid Rafts in Pancreatic Alpha-cells: Effects on Glucagon Stimulus-secretion Coupling Endocrinology. May, 2007 | Pubmed ID: 17303668 Distinct Modulation of Kv1.2 Channel Gating by Wild Type, but Not Open Form, of Syntaxin-1A American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2007 | Pubmed ID: 17234891 Recent Insights into the Cellular Mechanisms of Acute Pancreatitis Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. Jan, 2007 | Pubmed ID: 17225878 Characterization of VAMP-2 Gene from Marine Teleostean, Lateolabrax Japonicus Science in China. Series C, Life Sciences. Dec, 2006 | Pubmed ID: 17312998 Blanco Solubles Sensibles a N-etilmaleimida Factor Accesorio Proteínas Receptores (t-SNAREs) Regulan Diferentemente Activación Y Compuerta De Inactivación De Kv2.2 Y Kv2.1: Implicaciones En Islotes Pancreáticos Kv Canales De La Célula Molecular Pharmacology. Sep, 2006 | Pubmed ID: 16754785 The Neuronal Ca2+ Sensor Protein Visinin-like Protein-1 is Expressed in Pancreatic Islets and Regulates Insulin Secretion The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16731532 Two Populations of Pancreatic Islet Alpha-cells Displaying Distinct Ca2+ Channel Properties Biochemical and Biophysical Research Communications. Jun, 2006 | Pubmed ID: 16678791 Syntaxin-1A Actions on Sulfonylurea Receptor 2A Can Block Acidic PH-induced Cardiac K(ATP) Channel Activation The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16672225 Role of the Exchange Protein Directly Activated by Cyclic Adenosine 5'-monophosphate (Epac) Pathway in Regulating Proglucagon Gene Expression in Intestinal Endocrine L Cells Endocrinology. Aug, 2006 | Pubmed ID: 16644915 Munc13-1 Deficiency Reduces Insulin Secretion and Causes Abnormal Glucose Tolerance Diabetes. May, 2006 | Pubmed ID: 16644700 Involvement of VAMP-2 in Exocytosis of IL-1 Beta in Turbot (Scophthalmus Maximus) Leukocytes After Vibrio Anguillarum Infection Biochemical and Biophysical Research Communications. Apr, 2006 | Pubmed ID: 16487935 Modulation of Kv2.1 Channel Gating and TEA Sensitivity by Distinct Domains of SNAP-25 The Biochemical Journal. Jun, 2006 | Pubmed ID: 16478442 La Insulina Regula Islet Alpha Función De Las Células Mediante La Reducción De La Sensibilidad Del Canal KATP a La Adenosina-5'-trifosfato Inhibición Endocrinology. May, 2006 | Pubmed ID: 16455778 Impaired Gene and Protein Expression of Exocytotic Soluble N-ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients Diabetes. Feb, 2006 | Pubmed ID: 16443778 Feline Lower Esophageal Sphincter Sling and Circular Muscles Have Different Functional Inhibitory Neuronal Responses American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2006 | Pubmed ID: 16166343 Transgenic Mouse Overexpressing Syntaxin-1A As a Diabetes Model Diabetes. Sep, 2005 | Pubmed ID: 16123365 Glucagon-like Peptide 1 Regulates Sequential and Compound Exocytosis in Pancreatic Islet Beta-cells Diabetes. Sep, 2005 | Pubmed ID: 16123364 Caracterización Electrofisiológica De Las Células De Los Islotes Pancreáticos En La Insulina De Ratón Promotor-verde Del Ratón Proteína Fluorescente Endocrinology. Nov, 2005 | Pubmed ID: 16109783 Caspase-3-dependent Beta-cell Apoptosis in the Initiation of Autoimmune Diabetes Mellitus Molecular and Cellular Biology. May, 2005 | Pubmed ID: 15831467 Regional Differences in Cholinergic Regulation of Potassium Current in Feline Esophageal Circular Smooth Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2005 | Pubmed ID: 15691872 Open Form of Syntaxin-1A is a More Potent Inhibitor Than Wild-type Syntaxin-1A of Kv2.1 Channels The Biochemical Journal. Apr, 2005 | Pubmed ID: 15518587 H3 Domain of Syntaxin 1A Inhibits KATP Channels by Its Actions on the Sulfonylurea Receptor 1 Nucleotide-binding Folds-1 and -2 The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15485808 Syntaxin-1A Inhibits Cardiac KATP Channels by Its Actions on Nucleotide Binding Folds 1 and 2 of Sulfonylurea Receptor 2A The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15339904 Regional Differences in L-type Ca2+ Channel Expression in Feline Lower Esophageal Sphincter American Journal of Physiology. Gastrointestinal and Liver Physiology. Oct, 2004 | Pubmed ID: 15178551 Alcoholic Chronic Pancreatitis Involves Displacement of Munc18c from the Pancreatic Acinar Basal Membrane Surface Pancreas. May, 2004 | Pubmed ID: 15097857 Disruption of Pancreatic Beta-cell Lipid Rafts Modifies Kv2.1 Channel Gating and Insulin Exocytosis The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15073181 Syntaxin-1A Binds the Nucleotide-binding Folds of Sulphonylurea Receptor 1 to Regulate the KATP Channel The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14645230 Calcium Source Diversity in Feline Lower Esophageal Sphincter Circular and Sling Muscle American Journal of Physiology. Gastrointestinal and Liver Physiology. Feb, 2004 | Pubmed ID: 14563670 Regulation of Insulin Exocytosis by Munc13-1 The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12871971 Interacción Directa De Las Trampas Del Destino Con El Canal De Kv2.1. Regulación Modal De Activación Del Canal Y Compuerta De Inactivación The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12807875 SNAP-25 Inhibits L-type Ca2+ Channels in Feline Esophagus Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jun, 2003 | Pubmed ID: 12788104 Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12621036 Effects of Selective Endocrine or Exocrine Induction of AR42J on SNARE and Munc18 Protein Expression Pancreas. Nov, 2002 | Pubmed ID: 12409842 Synaptosome-associated Protein of 25 Kilodaltons Modulates Kv2.1 Voltage-dependent K(+) Channels in Neuroendocrine Islet Beta-cells Through an Interaction with the Channel N Terminus Molecular Endocrinology (Baltimore, Md.). Nov, 2002 | Pubmed ID: 12403834 Abnormal Expression of Pancreatic Islet Exocytotic Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptors in Goto-Kakizaki Rats is Partially Restored by Phlorizin Treatment and Accentuated by High Glucose Treatment Endocrinology. Nov, 2002 | Pubmed ID: 12399415 Modulación De Canales De Tipo L De CA Por Distintos Dominios Dentro De SNAP-25 Diabetes. May, 2002 | Pubmed ID: 11978639 Visualization of Sequential Exocytosis in Rat Pancreatic Islet Beta Cells Biochemical and Biophysical Research Communications. Apr, 2002 | Pubmed ID: 11944911 The 25-kDa Synaptosome-associated Protein (SNAP-25) Binds and Inhibits Delayed Rectifier Potassium Channels in Secretory Cells The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11925439 SNAP-25, a SNARE Protein, Inhibits Two Types of K Channels in Esophageal Smooth Muscle Gastroenterology. Apr, 2002 | Pubmed ID: 11910352 De neuropéptido Y-pHluorin de la proyección de imagen confocal: una técnica para visualizar la exocitosis de gránulos de insulina en islotes humanos y murinos intactos Madina Makhmutova1, Tao Liang2, Herbert Gaisano2, Alejandro Caicedo1, Joana Almaça1 1Department of Medicine, University of Miami, 2Department of Medicine, University of Toronto JoVE 56089 生物学
De neuropéptido Y-pHluorin de la proyección de imagen confocal: una técnica para visualizar la exocitosis de gránulos de insulina en islotes humanos y murinos intactos Madina Makhmutova1, Tao Liang2, Herbert Gaisano2, Alejandro Caicedo1, Joana Almaça1 1Department of Medicine, University of Miami, 2Department of Medicine, University of Toronto JoVE 56089 生物学