Neil R. Cashman Department of Neurology University of British Columbia Biography Publications Institution JoVE Articles Neil R. Cashman has not added a biography. If you are Neil R. Cashman and would like to personalize this page please email our Author Liaison for assistance. Publications From Molecule to Molecule and Cell to Cell: Prion-like Mechanisms in Amyotrophic Lateral Sclerosis Neurobiology of Disease. Feb, 2015 | Pubmed ID: 25701498 Exosome-dependent and Independent Mechanisms Are Involved in Prion-like Transmission of Propagated Cu/Zn Superoxide Dismutase Misfolding Prion. 2014 | Pubmed ID: 25551548 A Meta-analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine. Dec, 2014 | Pubmed ID: 25479292 Intermediate CAG Repeat Expansion in the ATXN2 Gene is a Unique Genetic Risk Factor for ALS--a Systematic Review and Meta-analysis of Observational Studies PloS One. 2014 | Pubmed ID: 25148523 Update on the Provisional Estimation of Developing Iatrogenic Variant Creutzfeldt-Jakob Disease from Human Islet Cell Transplantation Procedures Transplantation. Jun, 2014 | Pubmed ID: 24933255 Intercellular Propagated Misfolding of Wild-type Cu/Zn Superoxide Dismutase Occurs Via Exosome-dependent and -independent Mechanisms Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014 | Pubmed ID: 24550511 Safety, Specificity and Immunogenicity of a PrP(Sc)-specific Prion Vaccine Based on the YYR Disease Specific Epitope Prion. Jan-Feb, 2014 | Pubmed ID: 24509522 Development of a Multivalent, PrP(Sc)-specific Prion Vaccine Through Rational Optimization of Three Disease-specific Epitopes Vaccine. Apr, 2014 | Pubmed ID: 24486363 Interpretation of Cerebrospinal Fluid Protein Tests in the Diagnosis of Sporadic Creutzfeldt-Jakob Disease: an Evidence-based Approach CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Jun, 2014 | Pubmed ID: 24446456 Prion-like Activity of Cu/Zn Superoxide Dismutase: Implications for Amyotrophic Lateral Sclerosis Prion. Jan-Feb, 2014 | Pubmed ID: 24394345 Nanopore Analysis Reveals Differences in Structural Stability of Ovine PrP(C) Proteins Corresponding to Scrapie Susceptible (VRQ) and Resistance (ARR) Genotypes Prion. Nov-Dec, 2013 | Pubmed ID: 24401607 The Prion Protein Modulates A-type K+ Currents Mediated by Kv4.2 Complexes Through Dipeptidyl Aminopeptidase-like Protein 6 The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24225951 The Prion Protein Ligand, Stress-inducible Phosphoprotein 1, Regulates Amyloid-β Oligomer Toxicity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2013 | Pubmed ID: 24133259 PrP(Sc)-specific Antibodies Do Not Induce Prion Disease or Misfolding of PrP(C) in Highly Susceptible Tga20 Mice Prion. Sep-Oct, 2013 | Pubmed ID: 24105298 Binding of Bovine T194A PrP(C) by PrP(Sc)-specific Antibodies: Potential Implications for Immunotherapy of Familial Prion Diseases Prion. Jul-Aug, 2013 | Pubmed ID: 23787697 Nanopore Analysis of Wild-type and Mutant Prion Protein (PrP(C)): Single Molecule Discrimination and PrP(C) Kinetics PloS One. 2013 | Pubmed ID: 23393562 A Special Focus Issue on the Materials of Prion 2011 Meeting in Montreal, Canada Prion. Apr-Jun, 2012 | Pubmed ID: 22634715 Aberrant Localization of FUS and TDP43 is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis PloS One. 2012 | Pubmed ID: 22493728 Generalization of the Prion Hypothesis to Other Neurodegenerative Diseases: an Imperfect Fit Journal of Toxicology and Environmental Health. Part A. 2011 | Pubmed ID: 22043906 Diagnostic Accuracy of Cerebrospinal Fluid Protein Markers for Sporadic Creutzfeldt-Jakob Disease in Canada: a 6-year Prospective Study BMC Neurology. 2011 | Pubmed ID: 22032272 Intermolecular Transmission of Superoxide Dismutase 1 Misfolding in Living Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21930926 Sterol Regulatory Element Binding Protein-1 (SREBP1) Activation in Motor Neurons in Excitotoxicity and Amyotrophic Lateral Sclerosis (ALS): Indip, a Potential Therapeutic Peptide Biochemical and Biophysical Research Communications. Sep, 2011 | Pubmed ID: 21871872 The Prion Protein Binds Thiamine The FEBS Journal. Nov, 2011 | Pubmed ID: 21848803 Relative and Regional Stabilities of the Hamster, Mouse, Rabbit, and Bovine Prion Proteins Toward Urea Unfolding Assessed by Nuclear Magnetic Resonance and Circular Dichroism Spectroscopies Biochemistry. Sep, 2011 | Pubmed ID: 21800884 An Overlapping Reading Frame in the PRNP Gene Encodes a Novel Polypeptide Distinct from the Prion Protein FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2011 | Pubmed ID: 21478263 Detection of Prion Protein in Urine-derived Injectable Fertility Products by a Targeted Proteomic Approach PloS One. 2011 | Pubmed ID: 21448279 A Theory for the Anisotropic and Inhomogeneous Dielectric Properties of Proteins Physical Chemistry Chemical Physics : PCCP. Apr, 2011 | Pubmed ID: 21359369 Differential Expression of C-Ret in Motor Neurons Versus Non-neuronal Cells is Linked to the Pathogenesis of ALS Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2011 | Pubmed ID: 21283077 Toward a Mechanism of Prion Misfolding and Structural Models of PrP(Sc): Current Knowledge and Future Directions Journal of Toxicology and Environmental Health. Part A. 2011 | Pubmed ID: 21218344 Preface. Prion Research in Perspective Journal of Toxicology and Environmental Health. Part A. 2011 | Pubmed ID: 21218335 Prion Disease Susceptibility is Affected by Beta-structure Folding Propensity and Local Side-chain Interactions in PrP Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21041683 Immunotherapy for Prion Diseases: Opportunities and Obstacles Immunotherapy. Mar, 2010 | Pubmed ID: 20635933 Electrostatics in the Stability and Misfolding of the Prion Protein: Salt Bridges, Self Energy, and Solvation Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Apr, 2010 | Pubmed ID: 20453937 Design and Delivery of a Cryptic PrP(C) Epitope for Induction of PrP(Sc)-specific Antibody Responses Vaccine. Jan, 2010 | Pubmed ID: 19925901 Prion Protein Expression and Release by Mast Cells After Activation The Journal of Infectious Diseases. Sep, 2009 | Pubmed ID: 19642931 Immunological Mimicry of PrPC-PrPSc Interactions: Antibody-induced PrP Misfolding Protein Engineering, Design & Selection : PEDS. Aug, 2009 | Pubmed ID: 19602568 Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis PLoS Genetics. 2008 | Pubmed ID: 18802454 Selective Association of Misfolded ALS-linked Mutant SOD1 with the Cytoplasmic Face of Mitochondria Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18296640 Species Barriers for Chronic Wasting Disease by in Vitro Conversion of Prion Protein Biochemical and Biophysical Research Communications. Dec, 2007 | Pubmed ID: 17964288 An Immunological Epitope Selective for Pathological Monomer-misfolded SOD1 in ALS Nature Medicine. Jun, 2007 | Pubmed ID: 17486090 Decreased Cell Surface Prion Protein in Mouse Models of Prion Disease Neuroreport. Jan, 2007 | Pubmed ID: 17259851 Current and Future Molecular Diagnostics for Prion Diseases Expert Review of Molecular Diagnostics. Jul, 2006 | Pubmed ID: 16824033 Progress in Prion Vaccines and Immunotherapies Expert Opinion on Biological Therapy. Jan, 2005 | Pubmed ID: 15709913 Post-poliomyelitis Syndrome Muscle & Nerve. Jan, 2005 | Pubmed ID: 15599928 Mitochondrial Proteomic Analysis of a Cell Line Model of Familial Amyotrophic Lateral Sclerosis Molecular & Cellular Proteomics : MCP. Dec, 2004 | Pubmed ID: 15501831 Prion Diseases--close to Effective Therapy? Nature Reviews. Drug Discovery. Oct, 2004 | Pubmed ID: 15459678 Monomeric Cu,Zn-superoxide Dismutase is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14734542 Intrathecal B-cell Clonal Expansion, an Early Sign of Humoral Immunity, in the Cerebrospinal Fluid of Patients with Clinically Isolated Syndrome Suggestive of Multiple Sclerosis Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2003 | Pubmed ID: 12861047 A Prion Protein Epitope Selective for the Pathologically Misfolded Conformation Nature Medicine. Jul, 2003 | Pubmed ID: 12778138 Induced Adaptive Resistance to Oxidative Stress in the CNS: a Discussion on Possible Mechanisms and Their Therapeutic Potential Current Drug Metabolism. Apr, 2003 | Pubmed ID: 12678694 Gabapentin Therapy for Amyotrophic Lateral Sclerosis: Lack of Improvement in Neuronal Integrity Shown by MR Spectroscopy AJNR. American Journal of Neuroradiology. Mar, 2003 | Pubmed ID: 12637300 A Letter from CMAJ's Editorial Board to the CMA CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Nov, 2002 | Pubmed ID: 12451066 Oxidation-induced Misfolding and Aggregation of Superoxide Dismutase and Its Implications for Amyotrophic Lateral Sclerosis The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12356748 Acidic PH and Detergents Enhance in Vitro Conversion of Human Brain PrPC to a PrPSc-like Form The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12161431 Het beoordelen van overdraagbare spongiforme encefalopathie Soort Barrières met een Christopher J. Johnson1, Christina M. Carlson2, Aaron R. Morawski3, Alyson Manthei4, Neil R. Cashman5 1USGS National Wildlife Health Center, 2Department of Soil Science, University of Wisconsin–Madison, 3Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4Merial Veterinary Scholars Program, School of Veterinary Medicine, University of Wisconsin–Madison, 5Department of Neurology, University of British Columbia 医学
Het beoordelen van overdraagbare spongiforme encefalopathie Soort Barrières met een Christopher J. Johnson1, Christina M. Carlson2, Aaron R. Morawski3, Alyson Manthei4, Neil R. Cashman5 1USGS National Wildlife Health Center, 2Department of Soil Science, University of Wisconsin–Madison, 3Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4Merial Veterinary Scholars Program, School of Veterinary Medicine, University of Wisconsin–Madison, 5Department of Neurology, University of British Columbia 医学