Paul Brennan Systems Immunity Research Institute, Division of Infection and Immunity Cardiff University Biography Publications Institution JoVE Articles Paul Brennan has not added a biography. If you are Paul Brennan and would like to personalize this page please email our Author Liaison for assistance. Publications Essential Role of Staff Development in Addressing Structural Racism Lancet (London, England). Jun, 2023 | Pubmed ID: 37330737 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report The New England Journal of Medicine. Nov, 2021 | Pubmed ID: 34758253 Kinomics Platform Using GBM Tissue Identifies BTK As Being Associated with Higher Patient Survival Life Science Alliance. Dec, 2021 | Pubmed ID: 34645618 DrawProteins: a Bioconductor/R Package for Reproducible and Programmatic Generation of Protein Schematics F1000Research. 2018 | Pubmed ID: 30210791 Genome-wide Association Analysis Implicates Dysregulation of Immunity Genes in Chronic Lymphocytic Leukaemia Nature Communications. 02, 2017 | Pubmed ID: 28165464 Key Molecular Drivers of Chronic Lymphocytic Leukemia Clinical Lymphoma, Myeloma & Leukemia. Nov, 2016 | Pubmed ID: 27601002 Proteomics Analysis of Vesicles Isolated from Plasma and Urine of Prostate Cancer Patients Using a Multiplex, Aptamer-based Protein Array Journal of Extracellular Vesicles. 2016 | Pubmed ID: 27363484 External Ventricular Drainage: Is It Time to Look at National Practice? British Journal of Neurosurgery. Feb, 2015 | Pubmed ID: 25188651 Proteomics-based Strategies to Identify Proteins Relevant to Chronic Lymphocytic Leukemia Journal of Proteome Research. Nov, 2014 | Pubmed ID: 24983324 Development and Characterization of a Physiologically Relevant Model of Lymphocyte Migration in Chronic Lymphocytic Leukemia Blood. Jun, 2014 | Pubmed ID: 24637360 A Novel Cdk9 Inhibitor Preferentially Targets Tumor Cells and Synergizes with Fludarabine Oncotarget. Jan, 2014 | Pubmed ID: 24495868 Blinatumomab Induces Autologous T-cell Killing of Chronic Lymphocytic Leukemia Cells Haematologica. Dec, 2013 | Pubmed ID: 23812940 Reactive Oxygen Species and Mitochondrial Sensitivity to Oxidative Stress Determine Induction of Cancer Cell Death by P21 The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22311974 Defining the Prognosis of Early Stage Chronic Lymphocytic Leukaemia Patients British Journal of Haematology. Feb, 2012 | Pubmed ID: 22171799 Proteomic Profiling of Human Respiratory Epithelia by ITRAQ Reveals Biomarkers of Exposure and Harm by Tobacco Smoke Components Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. Nov, 2011 | Pubmed ID: 21966894 Co-operative Membrane Disruption Between Cell-penetrating Peptide and Cargo: Implications for the Therapeutic Use of the Bcl-2 Converter Peptide D-NuBCP-9-r8 Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2011 | Pubmed ID: 21934653 Proteomics Analysis of Bladder Cancer Exosomes Molecular & Cellular Proteomics : MCP. Jun, 2010 | Pubmed ID: 20224111 Genetic Modification of Primary Chronic Lymphocytic Leukemia Cells with a Lentivirus Expressing CD38 Haematologica. Mar, 2010 | Pubmed ID: 20207849 Bicarbonate-dependent Serine/threonine Protein Dephosphorylation in Capacitating Boar Spermatozoa Journal of Andrology. 2010 | Pubmed ID: 20203338 Interplay Between REST and Nucleolin Transcription Factors: a Key Mechanism in the Overexpression of Genes Upon Increased Phosphorylation Nucleic Acids Research. May, 2010 | Pubmed ID: 20100803 Quantitative Nuclear Proteomics Reveals New Phenotypes Altered in Lymphoblastoid Cells Proteomics. Clinical Applications. Mar, 2009 | Pubmed ID: 26238753 NF-kappaB As a Prognostic Marker and Therapeutic Target in Chronic Lymphocytic Leukemia Future Oncology (London, England). Sep, 2009 | Pubmed ID: 19792971 Soluble TLR2 Reduces Inflammation Without Compromising Bacterial Clearance by Disrupting TLR2 Triggering Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542461 STAT1 Contributes to the Maintenance of the Latency III Viral Programme Observed in Epstein-Barr Virus-transformed B Cells and Their Recognition by CD8+ T Cells The Journal of General Virology. Sep, 2009 | Pubmed ID: 19439556 Cellular Uptake, Distribution and Cytotoxicity of the Hydrophobic Cell Penetrating Peptide Sequence PFVYLI Linked to the Proapoptotic Domain Peptide PAD Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2009 | Pubmed ID: 19409429 Rel a is an Independent Biomarker of Clinical Outcome in Chronic Lymphocytic Leukemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2009 | Pubmed ID: 19124804 The Novel Nuclear Factor-kappaB Inhibitor LC-1 is Equipotent in Poor Prognostic Subsets of Chronic Lymphocytic Leukemia and Shows Strong Synergy with Fludarabine Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2008 | Pubmed ID: 19088025 Targeting Transcription Factors for Therapeutic Benefit Molecular BioSystems. Sep, 2008 | Pubmed ID: 18704229 Mcl-1 Expression Has in Vitro and in Vivo Significance in Chronic Lymphocytic Leukemia and is Associated with Other Poor Prognostic Markers Blood. Nov, 2008 | Pubmed ID: 18599795 Proliferation and Interleukin 5 Production by CD8hi CD57+ T Cells European Journal of Immunology. Apr, 2008 | Pubmed ID: 18383036 The NF-kappaB Subunit Rel A is Associated with in Vitro Survival and Clinical Disease Progression in Chronic Lymphocytic Leukemia and Represents a Promising Therapeutic Target Blood. May, 2008 | Pubmed ID: 18227347 Epstein-Barr Virus Induces a Distinct Form of DNA-bound STAT1 Compared with That Found in Interferon-stimulated B Lymphocytes The Journal of General Virology. Jul, 2007 | Pubmed ID: 17554018 Epstein-Barr Virus Represses the FoxO1 Transcription Factor Through Latent Membrane Protein 1 and Latent Membrane Protein 2A Journal of Virology. Nov, 2006 | Pubmed ID: 16943287 Expression of Glycosylphosphatidylinositol-anchored CD59 on Target Cells Enhances Human NK Cell-mediated Cytotoxicity Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493049 Mutation of the Extracellular Domain of Tumour Necrosis Factor Receptor 1 Causes Reduced NF-kappaB Activation Due to Decreased Surface Expression FEBS Letters. Sep, 2005 | Pubmed ID: 16162344 Susceptibility of B Lymphocytes to Adenovirus Type 5 Infection is Dependent Upon Both Coxsackie-adenovirus Receptor and Alphavbeta5 Integrin Expression The Journal of General Virology. Jun, 2005 | Pubmed ID: 15914844 Reduced Tumor Necrosis Factor Signaling in Primary Human Fibroblasts Containing a Tumor Necrosis Factor Receptor Superfamily 1A Mutant Arthritis and Rheumatism. Apr, 2005 | Pubmed ID: 15818692 LY294002 and Rapamycin Co-operate to Inhibit T-cell Proliferation British Journal of Pharmacology. Mar, 2005 | Pubmed ID: 15778701 CD22 is a Functional Ligand for SH2 Domain-containing Protein-tyrosine Phosphatase-1 in Primary T Cells The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15364920 Mechanism of Action of a Novel Latent Membrane Protein-1 Dominant Negative The Journal of Biological Chemistry. Jan, 2001 | Pubmed ID: 11031256 Effective Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors Molecular Therapy. Methods & Clinical Development. | Pubmed ID: 31720306 Author Spotlight: Exploring Macrophage Immunometabolism Through Lentiviral Vector-Mediated Gene Manipulation Mark Gurney1, Luke C. Davies1,2, Ruth E. Jones1, Valentina M. Bart1, Robert H. Jenkins1, Paul Brennan1, Philip R. Taylor1,3, Magdalena A. Czubala1 1Systems Immunity Research Institute, Division of Infection and Immunity, Cardiff University, 2Biomedical Sciences Unit, Faculty of Medicine, Health and Life Science, Swansea University, 3UK Dementia Research Institute JoVE 64926 免疫与感染
Author Spotlight: Exploring Macrophage Immunometabolism Through Lentiviral Vector-Mediated Gene Manipulation Mark Gurney1, Luke C. Davies1,2, Ruth E. Jones1, Valentina M. Bart1, Robert H. Jenkins1, Paul Brennan1, Philip R. Taylor1,3, Magdalena A. Czubala1 1Systems Immunity Research Institute, Division of Infection and Immunity, Cardiff University, 2Biomedical Sciences Unit, Faculty of Medicine, Health and Life Science, Swansea University, 3UK Dementia Research Institute JoVE 64926 免疫与感染