Pieter S. Hiemstra PulmoScience Laboratory, Department of Pulmonology Leiden University Medical Center Biography Publications Institution JoVE Articles Pieter S. Hiemstra has not added a biography. If you are Pieter S. Hiemstra and would like to personalize this page please email our Author Liaison for assistance. Publications Smoking Increases Expression of the SARS-CoV-2 Spike Protein-binding Long ACE2 Isoform in Bronchial Epithelium Respiratory Research. May, 2023 | Pubmed ID: 37170105 Multi-ancestry Genome-wide Association Analyses Improve Resolution of Genes and Pathways Influencing Lung Function and Chronic Obstructive Pulmonary Disease Risk Nature Genetics. Mar, 2023 | Pubmed ID: 36914875 Th2 High and Mast Cell Gene Signatures Are Associated with Corticosteroid Sensitivity in COPD Thorax. Apr, 2023 | Pubmed ID: 36598042 Combination of IL-17A/F and TNF-α Uniquely Alters the Bronchial Epithelial Cell Proteome to Enhance Proteins That Augment Neutrophil Migration Journal of Inflammation (London, England). Dec, 2022 | Pubmed ID: 36517803 SARS-CoV-2-specific CD4 and CD8 T Cell Responses Can Originate from Cross-reactive CMV-specific T Cells ELife. Nov, 2022 | Pubmed ID: 36408799 Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling Antioxidants (Basel, Switzerland). Oct, 2022 | Pubmed ID: 36290742 The Lower Airways Microbiota and Antimicrobial Peptides Indicate Dysbiosis in Sarcoidosis Microbiome. Oct, 2022 | Pubmed ID: 36258251 Early Transcriptional Responses of Bronchial Epithelial Cells to Whole Cigarette Smoke Mirror Those of In-vivo Exposed Human Bronchial Mucosa Respiratory Research. Sep, 2022 | Pubmed ID: 36056356 Keratin 8 is a Scaffolding and Regulatory Protein of ERAD Complexes Cellular and Molecular Life Sciences : CMLS. Sep, 2022 | Pubmed ID: 36045259 Association of Bronchial Steroid Inducible Methylation Quantitative Trait Loci with Asthma and Chronic Obstructive Pulmonary Disease Treatment Response Clinical and Translational Allergy. Aug, 2022 | Pubmed ID: 36036237 Host Succinate Inhibits Influenza Virus Infection Through Succinylation and Nuclear Retention of the Viral Nucleoprotein The EMBO Journal. Jun, 2022 | Pubmed ID: 35506364 3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes ACS Biomaterials Science & Engineering. Jun, 2022 | Pubmed ID: 35502997 Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease Patients with Low Serum Vitamin D: a Randomized Controlled Trial The American Journal of Clinical Nutrition. Aug, 2022 | Pubmed ID: 35383823 High MiR203a-3p and MiR-375 Expression in the Airways of Smokers with and Without COPD Scientific Reports. Apr, 2022 | Pubmed ID: 35379844 Dysregulated Mitochondrial Metabolism Upon Cigarette Smoke Exposure in Various Human Bronchial Epithelial Cell Models Disease Models & Mechanisms. Mar, 2022 | Pubmed ID: 35344036 Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort Pathogens (Basel, Switzerland). Mar, 2022 | Pubmed ID: 35335664 Role of Air Pollutants in Airway Epithelial Barrier Dysfunction in Asthma and COPD European Respiratory Review : an Official Journal of the European Respiratory Society. Mar, 2022 | Pubmed ID: 35321933 Organoid-based Expansion of Patient-derived Primary Alveolar Type 2 Cells for Establishment of Alveolus Epithelial Lung-Chip Cultures American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2022 | Pubmed ID: 35137633 Lung Epithelial Cells Interact with Immune Cells and Bacteria to Shape the Microenvironment in Tuberculosis Thorax. Apr, 2022 | Pubmed ID: 35017314 The Lower Airways Microbiome and Antimicrobial Peptides in Idiopathic Pulmonary Fibrosis Differ from Chronic Obstructive Pulmonary Disease PloS One. 2022 | Pubmed ID: 34990493 Prolonged Activation of Nasal Immune Cell Populations and Development of Tissue-resident SARS-CoV-2-specific CD8 T Cell Responses Following COVID-19 Nature Immunology. Jan, 2022 | Pubmed ID: 34937933 Determinants of Expression of SARS-CoV-2 Entry-related Genes in Upper and Lower Airways Allergy. Feb, 2022 | Pubmed ID: 34698405 Novel Insights into Surfactant Protein C Trafficking Revealed Through the Study of a Pathogenic Mutant The European Respiratory Journal. Jan, 2022 | Pubmed ID: 34049951 Bronchial Gene Expression Signature Associated with Rate of Subsequent FEV Decline in Individuals with and at Risk of COPD Thorax. Jan, 2022 | Pubmed ID: 33972452 Personalized Pollen Monitoring and Symptom Scores: A Feasibility Study in Grass Pollen Allergic Patients Frontiers in Allergy. 2021 | Pubmed ID: 35387060 Kallikrein-related Peptidase 5 Contributes to the Remodeling and Repair of Bronchial Epithelium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2021 | Pubmed ID: 34582061 Factors Associated with Physical Activity Among COPD Patients with Mild or Moderate Airflow Obstruction Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace. Sep, 2021 | Pubmed ID: 34523325 Disease Modeling Following Organoid-based Expansion of Airway Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2021 | Pubmed ID: 34378410 The Course of AαVal541 As a Proteinase 3 Specific Neo-Epitope After Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360796 Comparison of Genome-wide Gene Expression Profiling by RNA Sequencing Microarray in Bronchial Biopsies of COPD Patients Before and After Inhaled Corticosteroid Treatment: Does It Provide New Insights? ERJ Open Research. Apr, 2021 | Pubmed ID: 34164552 Repairing Damaged Lungs Using Regenerative Therapy Current Opinion in Pharmacology. Aug, 2021 | Pubmed ID: 34161852 Gender Specific Airway Gene Expression in COPD Sub-phenotypes Supports a Role of Mitochondria and of Different Types of Leukocytes Scientific Reports. Jun, 2021 | Pubmed ID: 34145303 RAGE and TLR4 Differentially Regulate Airway Hyperresponsiveness: Implications for COPD Allergy. Apr, 2021 | Pubmed ID: 32799375 A New Portable Sampler to Monitor Pollen at Street Level in the Environment of Patients The Science of the Total Environment. Nov, 2020 | Pubmed ID: 32887011 An Emerging Class of Air Pollutants: Potential Effects of Microplastics to Respiratory Human Health? The Science of the Total Environment. Dec, 2020 | Pubmed ID: 32827829 Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases Frontiers in Immunology. 2020 | Pubmed ID: 32754156 Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production Via Multiple Mechanisms in Differentiated Airway Epithelial Cells Frontiers in Cellular and Infection Microbiology. 2020 | Pubmed ID: 32637364 Wnt/β-catenin Signaling is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema Stem Cells (Dayton, Ohio). Nov, 2020 | Pubmed ID: 32526076 Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle Antimicrobial Agents and Chemotherapy. Jul, 2020 | Pubmed ID: 32513797 Host-microbe Cross-talk in the Lung Microenvironment: Implications for Understanding and Treating Chronic Lung Disease The European Respiratory Journal. Aug, 2020 | Pubmed ID: 32430415 Vitamin D Deficiency in Asthma and Chronic Obstructive Pulmonary Disease. A Chicken-or-Egg Story American Journal of Respiratory and Critical Care Medicine. Aug, 2020 | Pubmed ID: 32352312 Adiposity is a Confounding Factor Which Largely Explains the Association of Serum Vitamin D Concentrations with C-reactive Protein, Leptin and Adiponectin Cytokine. Jul, 2020 | Pubmed ID: 32325367 Short-term and Long-term Effect of a High-intensity Pulmonary Rehabilitation Programme in Obese Patients with Asthma: a Randomised Controlled Trial The European Respiratory Journal. Jul, 2020 | Pubmed ID: 32299852 Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages Journal of Innate Immunity. 2020 | Pubmed ID: 32289801 In Vitro Modelling of Alveolar Repair at the Air-liquid Interface Using Alveolar Epithelial Cells Derived from Human Induced Pluripotent Stem Cells Scientific Reports. Mar, 2020 | Pubmed ID: 32218519 ERS International Congress, Madrid, 2019: Highlights from the Basic and Translational Science Assembly ERJ Open Research. Jan, 2020 | Pubmed ID: 32154289 Tumor Mutational Load, CD8 T Cells, Expression of PD-L1 and HLA Class I to Guide Immunotherapy Decisions in NSCLC Patients Cancer Immunology, Immunotherapy : CII. May, 2020 | Pubmed ID: 32047958 Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Scientific Reports. Jan, 2020 | Pubmed ID: 31937899 Innate Immunity of the Lung Journal of Innate Immunity. 2020 | Pubmed ID: 31801141 Mitochondria: at the Crossroads of Regulating Lung Epithelial Cell Function in Chronic Obstructive Pulmonary Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2020 | Pubmed ID: 31693390 Blood Eosinophil Count and Airway Epithelial Transcriptome Relationships in COPD Versus Asthma Allergy. Feb, 2020 | Pubmed ID: 31506971 TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms Journal of Innate Immunity. 2020 | Pubmed ID: 30970352 Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Scientific Reports. Oct, 2019 | Pubmed ID: 31664154 The Respiratory Virome and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease PloS One. 2019 | Pubmed ID: 31647831 Translation of Findings to Patients with Asthma: a Timely and Compelling Challenge The European Respiratory Journal. Oct, 2019 | Pubmed ID: 31601723 Perioperative ProADM-change is Associated with the Development of Acute Respiratory Distress Syndrome in Critically Ill Cardiac Surgery Patients: a Prospective Cohort Study Biomarkers in Medicine. Sep, 2019 | Pubmed ID: 31544475 Sputum Microbiota and Inflammation at Stable State and During Exacerbations in a Cohort of Chronic Obstructive Pulmonary Disease (COPD) Patients PloS One. 2019 | Pubmed ID: 31527888 Airway and Alveolar Epithelial Cells in Culture The European Respiratory Journal. Nov, 2019 | Pubmed ID: 31515398 Extract of Helicobacter Pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia Following Repeated Allergen Exposure International Archives of Allergy and Immunology. 2019 | Pubmed ID: 31242493 From the Pathophysiology of the Human Lung Alveolus to Epigenetic Editing: Congress 2018 Highlights from ERS Assembly 3 "Basic and Translational Science." ERJ Open Research. Apr, 2019 | Pubmed ID: 31111040 Macrophage Function in Chronic Obstructive Pulmonary Disease: The Many Faces of Notch Signalling EBioMedicine. May, 2019 | Pubmed ID: 31047859 Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30980358 TGF-β Activation Impairs Fibroblast Ability to Support Adult Lung Epithelial Progenitor Cell Organoid Formation American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2019 | Pubmed ID: 30969812 Effect of Long-term Corticosteroid Treatment on MicroRNA and Gene-expression Profiles in COPD The European Respiratory Journal. Apr, 2019 | Pubmed ID: 30846474 Dynamic Differences in Dietary Polyunsaturated Fatty Acid Metabolism in Sputum of COPD Patients and Controls Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Mar, 2019 | Pubmed ID: 30528790 Electronic Cigarettes: a Task Force Report from the European Respiratory Society The European Respiratory Journal. Feb, 2019 | Pubmed ID: 30464018 Stem Cell-based Lung-on-Chips: The Best of Both Worlds? Advanced Drug Delivery Reviews. Feb, 2019 | Pubmed ID: 30009883 Air-Liquid Interface Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations Applied in Vitro Toxicology. Jun, 2018 | Pubmed ID: 32953944 How to Write a Response to the Reviewers of Your Manuscript Breathe (Sheffield, England). Dec, 2018 | Pubmed ID: 30519299 Retinoic Acid Signaling Balances Adult Distal Lung Epithelial Progenitor Cell Growth and Differentiation EBioMedicine. Oct, 2018 | Pubmed ID: 30236449 Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases Vaccines. Jul, 2018 | Pubmed ID: 30060554 Immunomodulatory Innate Defence Regulator (IDR) Peptide Alleviates Airway Inflammation and Hyper-responsiveness Thorax. Oct, 2018 | Pubmed ID: 29853649 Aerobic Exercise Protects from Pseudomonas Aeruginosa-Induced Pneumonia in Elderly Mice Journal of Innate Immunity. 2018 | Pubmed ID: 29843140 A Novel Method for Expansion and Differentiation of Mouse Tracheal Epithelial Cells in Culture Scientific Reports. May, 2018 | Pubmed ID: 29743551 Basic and Translational Research in the The European Respiratory Journal. May, 2018 | Pubmed ID: 29724787 Predictive Value of Eosinophils and Neutrophils on Clinical Effects of ICS in COPD Respirology (Carlton, Vic.). Nov, 2018 | Pubmed ID: 29696728 Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease Chinese Medical Journal. May, 2018 | Pubmed ID: 29692382 Response to Comment on "Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease" Journal of Immunology (Baltimore, Md. : 1950). May, 2018 | Pubmed ID: 29685947 Mesenchymal Stromal Cells: a Novel Therapy for the Treatment of Chronic Obstructive Pulmonary Disease? Thorax. Jun, 2018 | Pubmed ID: 29653970 Aberrant Epithelial Differentiation by Cigarette Smoke Dysregulates Respiratory Host Defence The European Respiratory Journal. Apr, 2018 | Pubmed ID: 29545277 Effects of E-Cigarette Use on Human Lung Tissue. On Harm Reduction and Causing Harm American Journal of Respiratory and Critical Care Medicine. Jul, 2018 | Pubmed ID: 29518342 Assembly 3: Basic and Translational Sciences Breathe (Sheffield, England). Mar, 2018 | Pubmed ID: 29515672 Farm Dust Reduces Viral Load in Human Bronchial Epithelial Cells by Increasing Barrier Function and Antiviral Responses The Journal of Allergy and Clinical Immunology. May, 2018 | Pubmed ID: 29425849 Effect of Diesel Exhaust Generated by a City Bus Engine on Stress Responses and Innate Immunity in Primary Bronchial Epithelial Cell Cultures Toxicology in Vitro : an International Journal Published in Association with BIBRA. Apr, 2018 | Pubmed ID: 29408669 Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease Journal of Immunology (Baltimore, Md. : 1950). Mar, 2018 | Pubmed ID: 29352004 Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population Nutrients. Jan, 2018 | Pubmed ID: 29301349 Human Lung Epithelial Cell Cultures for Analysis of Inhaled Toxicants: Lessons Learned and Future Directions Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2018 | Pubmed ID: 29155131 Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure American Journal of Respiratory Cell and Molecular Biology. Feb, 2018 | Pubmed ID: 28933915 Pulmonary Function, Exhaled Nitric Oxide and Symptoms in Asthma Patients with Obesity: a Cross-sectional Study Respiratory Research. Dec, 2017 | Pubmed ID: 29212496 Reprogramming of Cellular Metabolism: Driver for Airway Remodelling in COPD? The European Respiratory Journal. Nov, 2017 | Pubmed ID: 29191957 MicroRNA Profiling in Lung Tissue and Bronchoalveolar Lavage of Cigarette Smoke-exposed Mice and in COPD Patients: a Translational Approach Scientific Reports. Oct, 2017 | Pubmed ID: 28993685 Acute and Chronic Effects of Treatment with Mesenchymal Stromal Cells on LPS-induced Pulmonary Inflammation, Emphysema and Atherosclerosis Development PloS One. 2017 | Pubmed ID: 28910300 Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery Obesity Surgery. Nov, 2017 | Pubmed ID: 28831733 The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice International Journal of Molecular Sciences. Aug, 2017 | Pubmed ID: 28792474 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 Cigarette Smoke Differentially Affects IL-13-induced Gene Expression in Human Airway Epithelial Cells Physiological Reports. Jul, 2017 | Pubmed ID: 28701525 The Effect of Tiotropium in Combination with Olodaterol on House Dust Mite-induced Allergic Airway Disease Pulmonary Pharmacology & Therapeutics. Aug, 2017 | Pubmed ID: 28687462 Airway Inflammation in COPD After Long-term Withdrawal of Inhaled Corticosteroids The European Respiratory Journal. Jun, 2017 | Pubmed ID: 28619964 Use of Airway Epithelial Cell Culture to Unravel the Pathogenesis and Study Treatment in Obstructive Airway Diseases Pulmonary Pharmacology & Therapeutics. Aug, 2017 | Pubmed ID: 28502841 Defining Asthma-COPD Overlap Syndrome: a Population-based Study The European Respiratory Journal. May, 2017 | Pubmed ID: 28461292 Antimicrobial Peptide Levels Are Linked to Airway Inflammation, Bacterial Colonisation and Exacerbations in Chronic Obstructive Pulmonary Disease The European Respiratory Journal. Mar, 2017 | Pubmed ID: 28298400 Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Jun, 2017 | Pubmed ID: 28231019 Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus Influenzae: Modulation by Cigarette Smoke Journal of Innate Immunity. 2017 | Pubmed ID: 28171878 Diesel Exhaust Alters the Response of Cultured Primary Bronchial Epithelial Cells from Patients with Chronic Obstructive Pulmonary Disease (COPD) to Non-typeable Haemophilus Influenzae Respiratory Research. Jan, 2017 | Pubmed ID: 28129777 Airway Inflammation in COPD After Long-term Withdrawal of Inhaled Corticosteroids The European Respiratory Journal. Jan, 2017 | Pubmed ID: 28049170 Xenobiotic Metabolism in Differentiated Human Bronchial Epithelial Cells Archives of Toxicology. May, 2017 | Pubmed ID: 27738743 Standard Radiotherapy but Not Chemotherapy Impairs Systemic Immunity in Non-small Cell Lung Cancer Oncoimmunology. 2016 | Pubmed ID: 28123900 Cigarette Smoke Modulates Repair and Innate Immunity Following Injury to Airway Epithelial Cells PloS One. 2016 | Pubmed ID: 27829065 Functional Characterisation of Bone Marrow-derived Mesenchymal Stromal Cells from COPD Patients ERJ Open Research. Apr, 2016 | Pubmed ID: 27730190 Basic Science of Electronic Cigarettes: Assessment in Cell Culture and in Vivo Models Respiratory Research. 10, 2016 | Pubmed ID: 27717371 ADAM17 and EGFR Regulate IL-6 Receptor and Amphiregulin MRNA Expression and Release in Cigarette Smoke-exposed Primary Bronchial Epithelial Cells from Patients with Chronic Obstructive Pulmonary Disease (COPD) Physiological Reports. Aug, 2016 | Pubmed ID: 27561911 Airway Hyperresponsiveness in Chronic Obstructive Pulmonary Disease: A marker of Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome? The Journal of Allergy and Clinical Immunology. Dec, 2016 | Pubmed ID: 27345171 The Dutch National Program for Respiratory Research The Lancet. Respiratory Medicine. May, 2016 | Pubmed ID: 27304557 Childhood Allergies and Asthma: New Insights on Environmental Exposures and Local Immunity at the Lung Barrier Current Opinion in Immunology. Oct, 2016 | Pubmed ID: 27254380 Azithromycin Differentially Affects the IL-13-induced Expression Profile in Human Bronchial Epithelial Cells Pulmonary Pharmacology & Therapeutics. Aug, 2016 | Pubmed ID: 27246785 Lung Function Decline in Asthma Patients with Elevated Bronchial CD8, CD4 and CD3 Cells The European Respiratory Journal. Aug, 2016 | Pubmed ID: 27230446 Cellular Response of Mucociliary Differentiated Primary Bronchial Epithelial Cells to Diesel Exhaust American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2016 | Pubmed ID: 27190060 Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus Aureus from Cultured Skin and Airway Epithelial Surfaces Antimicrobial Agents and Chemotherapy. Jul, 2016 | Pubmed ID: 27114278 Regeneration of the Lung: Lung Stem Cells and the Development of Lung Mimicking Devices Respiratory Research. Apr, 2016 | Pubmed ID: 27107715 Neutrophil-derived Alpha Defensins Control Inflammation by Inhibiting Macrophage MRNA Translation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27044108 Murine Models of Cardiovascular Comorbidity in Chronic Obstructive Pulmonary Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2016 | Pubmed ID: 26993520 Microbes and Asthma: Opportunities for Intervention The Journal of Allergy and Clinical Immunology. Mar, 2016 | Pubmed ID: 26947981 IL-13 and the Airway Epithelium. It Is All in the Genes American Journal of Respiratory and Critical Care Medicine. Feb, 2016 | Pubmed ID: 26871666 MicroRNA-223 Controls the Expression of Histone Deacetylase 2: a Novel Axis in COPD Journal of Molecular Medicine (Berlin, Germany). Jun, 2016 | Pubmed ID: 26864305 TNF-α and IL-1β-activated Human Mesenchymal Stromal Cells Increase Airway Epithelial Wound Healing in Vitro Via Activation of the Epidermal Growth Factor Receptor Respiratory Research. Jan, 2016 | Pubmed ID: 26753875 The Positive Prognostic Effect of Stromal CD8+ Tumor-infiltrating T Cells is Restrained by the Expression of HLA-E in Non-small Cell Lung Carcinoma Oncotarget. Jan, 2016 | Pubmed ID: 26658106 Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications Chest. Feb, 2016 | Pubmed ID: 26502035 Regulation of YKL-40 Expression by Corticosteroids: Effect on Pro-inflammatory Macrophages in Vitro and Its Modulation in COPD in Vivo Respiratory Research. Dec, 2015 | Pubmed ID: 26696093 Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial PloS One. 2015 | Pubmed ID: 26659582 Parallel Activities and Interactions Between Antimicrobial Peptides and Complement in Host Defense at the Airway Epithelial Surface Molecular Immunology. Nov, 2015 | Pubmed ID: 26597202 Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment PloS One. 2015 | Pubmed ID: 26545199 Therapeutic Potential of Soluble Guanylate Cyclase Modulators in Neonatal Chronic Lung Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2015 | Pubmed ID: 26432873 Prevention of Exacerbations in Patients with COPD and Vitamin D Deficiency Through Vitamin D Supplementation (PRECOVID): a Study Protocol BMC Pulmonary Medicine. Sep, 2015 | Pubmed ID: 26399451 Local and Systemic XAGE-1b-specific Immunity in Patients with Lung Adenocarcinoma Cancer Immunology, Immunotherapy : CII. Sep, 2015 | Pubmed ID: 26025564 Tiotropium Attenuates IL-13-induced Goblet Cell Metaplasia of Human Airway Epithelial Cells Thorax. Jul, 2015 | Pubmed ID: 25995156 Effect of Bariatric Surgery on Asthma Control, Lung Function and Bronchial and Systemic Inflammation in Morbidly Obese Subjects with Asthma Thorax. Jul, 2015 | Pubmed ID: 25934136 Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD PloS One. 2015 | Pubmed ID: 25803709 Brown Fat Activation Reduces Hypercholesterolaemia and Protects from Atherosclerosis Development Nature Communications. Mar, 2015 | Pubmed ID: 25754609 Basal Cells Contribute to Innate Immunity of the Airway Epithelium Through Production of the Antimicrobial Protein RNase 7 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25712218 The Innate Immune Function of Airway Epithelial Cells in Inflammatory Lung Disease The European Respiratory Journal. Apr, 2015 | Pubmed ID: 25700381 Asthma-COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Apr, 2015 | Pubmed ID: 25611785 Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease American Journal of Respiratory Cell and Molecular Biology. Aug, 2015 | Pubmed ID: 25514360 Brown Adipose Tissue Takes Up Plasma Triglycerides Mostly After Lipolysis Journal of Lipid Research. Jan, 2015 | Pubmed ID: 25351615 Function of Monocytes and Monocyte-derived Macrophages in α1-antitrypsin Deficiency The European Respiratory Journal. Feb, 2015 | Pubmed ID: 25323228 Dissecting the Genetics of Chronic Mucus Hypersecretion in Smokers with and Without COPD The European Respiratory Journal. Jan, 2015 | Pubmed ID: 25234806 Efficient and Sensitive Identification and Quantification of Airborne Pollen Using Next-generation DNA Sequencing Molecular Ecology Resources. Jan, 2015 | Pubmed ID: 24893805 Muscarinic M3 Receptors on Structural Cells Regulate Cigarette Smoke-induced Neutrophilic Airway Inflammation in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2014 | Pubmed ID: 25381025 Reproducibility of Exhaled Nitric Oxide Measurements in Overweight and Obese Adults BMC Research Notes. Nov, 2014 | Pubmed ID: 25366981 Club Cells, CC10 and Self-control at the Epithelial Surface The European Respiratory Journal. Oct, 2014 | Pubmed ID: 25271220 Genome-wide Association Analysis Identifies Six New Loci Associated with Forced Vital Capacity Nature Genetics. Jul, 2014 | Pubmed ID: 24929828 LL-37-derived Peptides Eradicate Multidrug-resistant Staphylococcus Aureus from Thermally Wounded Human Skin Equivalents Antimicrobial Agents and Chemotherapy. Aug, 2014 | Pubmed ID: 24841266 Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study PloS One. 2014 | Pubmed ID: 24714607 Steroid Resistance in COPD? Overlap and Differential Anti-inflammatory Effects in Smokers and Ex-smokers PloS One. 2014 | Pubmed ID: 24505290 Recent Progress in Peptide Vaccination in Cancer with a Focus on Non-small-cell Lung Cancer Expert Review of Vaccines. Jan, 2014 | Pubmed ID: 24308580 Increased ERK Signalling Promotes Inflammatory Signalling in Primary Airway Epithelial Cells Expressing Z α1-antitrypsin Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24097797 Airway Gene Expression in COPD is Dynamic with Inhaled Corticosteroid Treatment and Reflects Biological Pathways Associated with Disease Activity Thorax. Jan, 2014 | Pubmed ID: 23925644 Development and Validation of a 5-day-ahead Hay Fever Forecast for Patients with Grass-pollen-induced Allergic Rhinitis International Journal of Biometeorology. Aug, 2014 | Pubmed ID: 23780494 PH in Exhaled Breath Condensate and Nasal Lavage As a Biomarker of Air Pollution-related Inflammation in Street Traffic-controllers and Office-workers Clinics (Sao Paulo, Brazil). Dec, 2013 | Pubmed ID: 24473505 The Effect of PPE-induced Emphysema and Chronic LPS-induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice PloS One. 2013 | Pubmed ID: 24303000 Increase in Net Activity of Serine Proteinases but Not Gelatinases After Local Endotoxin Exposure in the Peripheral Airways of Healthy Subjects PloS One. 2013 | Pubmed ID: 24086430 Development of a Nose Cream Containing the Synthetic Antimicrobial Peptide P60.4Ac for Eradication of Methicillin-resistant Staphylococcus Aureus Carriage Journal of Pharmaceutical Sciences. Oct, 2013 | Pubmed ID: 23955373 Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: a Randomized, Controlled Trial PloS One. 2013 | Pubmed ID: 23667615 CD8(+) T Cells Characterize Early Smoking-related Airway Pathology in Patients with Asthma Respiratory Medicine. Jul, 2013 | Pubmed ID: 23639272 Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome Journal of Obesity. 2013 | Pubmed ID: 23509614 Resveratrol Protects Against Atherosclerosis, but Does Not Add to the Antiatherogenic Effect of Atorvastatin, in APOE*3-Leiden.CETP Mice The Journal of Nutritional Biochemistry. Aug, 2013 | Pubmed ID: 23337345 Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients by LC-MS/MS International Journal of Molecular Sciences. Oct, 2012 | Pubmed ID: 23203040 Toll-like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease PloS One. 2012 | Pubmed ID: 22952638 α1-antitrypsin Production by Proinflammatory and Antiinflammatory Macrophages and Dendritic Cells American Journal of Respiratory Cell and Molecular Biology. May, 2012 | Pubmed ID: 22162908 A Quantitative Method for Detection of Spliced X-box Binding Protein-1 (XBP1) MRNA As a Measure of Endoplasmic Reticulum (ER) Stress Cell Stress & Chaperones. Mar, 2012 | Pubmed ID: 22038282 Hepatocyte-specific IKKβ Expression Aggravates Atherosclerosis Development in APOE*3-Leiden Mice Atherosclerosis. Feb, 2012 | Pubmed ID: 21798539 Difference in Symptom Severity Between Early and Late Grass Pollen Season in Patients with Seasonal Allergic Rhinitis Clinical and Translational Allergy. Dec, 2011 | Pubmed ID: 22410160 PRAME-specific Allo-HLA-restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-cell Receptor Gene Transfer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2011 | Pubmed ID: 21771875 IL-4 and IL-13 Exposure During Mucociliary Differentiation of Bronchial Epithelial Cells Increases Antimicrobial Activity and Expression of Antimicrobial Peptides Respiratory Research. May, 2011 | Pubmed ID: 21529380 Smoking Status and Anti-inflammatory Macrophages in Bronchoalveolar Lavage and Induced Sputum in COPD Respiratory Research. Mar, 2011 | Pubmed ID: 21426578 The Role of IREB2 and Transforming Growth Factor Beta-1 Genetic Variants in COPD: a Replication Case-control Study BMC Medical Genetics. Feb, 2011 | Pubmed ID: 21320324 Severe Congenital Neutropenia in a Multigenerational Family with a Novel Neutrophil Elastase (ELANE) Mutation Annals of Hematology. Feb, 2011 | Pubmed ID: 20803142 Pro-inflammatory Mechanisms of Muscarinic Receptor Stimulation in Airway Smooth Muscle Respiratory Research. Sep, 2010 | Pubmed ID: 20875145 LL-37 Directs Macrophage Differentiation Toward Macrophages with a Proinflammatory Signature Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20610648 Multidrug Resistance-associated Protein-1 (MRP1) Genetic Variants, MRP1 Protein Levels and Severity of COPD Respiratory Research. May, 2010 | Pubmed ID: 20487524 Recent Advances in Alveolar Biology: Evolution and Function of Alveolar Proteins Respiratory Physiology & Neurobiology. Aug, 2010 | Pubmed ID: 20433956 Expression Patterns of Protein C Inhibitor in Mouse Development Journal of Molecular Histology. Feb, 2010 | Pubmed ID: 20229239 Association of MMP-2 Polymorphisms with Severe and Very Severe COPD: a Case Control Study of MMPs-1, 9 and 12 in a European Population BMC Medical Genetics. Jan, 2010 | Pubmed ID: 20078883 Effect of Fluticasone with and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease: a Randomized Trial Annals of Internal Medicine. Oct, 2009 | Pubmed ID: 19841453 Comparison of Exhaled Breath Condensate PH Using Two Commercially Available Devices in Healthy Controls, Asthma and COPD Patients Respiratory Research. Aug, 2009 | Pubmed ID: 19703285 Expression of Smooth Muscle and Extracellular Matrix Proteins in Relation to Airway Function in Asthma The Journal of Allergy and Clinical Immunology. May, 2008 | Pubmed ID: 18405955 An Antimicrobial Peptide Modulates Epithelial Responses to Bacterial Products The Laryngoscope. May, 2008 | Pubmed ID: 18300705 The Role of Epithelial Beta-defensins and Cathelicidins in Host Defense of the Lung Experimental Lung Research. Dec, 2007 | Pubmed ID: 18075828 Reduction in Sputum Neutrophil and Eosinophil Numbers by the PDE4 Inhibitor Roflumilast in Patients with COPD Thorax. Dec, 2007 | Pubmed ID: 17573446 Human Neutrophil Peptide-1 Inhibits Both the Classical and the Lectin Pathway of Complement Activation Molecular Immunology. Jul, 2007 | Pubmed ID: 17448537 Inhaled Nitric Oxide Attenuates Pulmonary Inflammation and Fibrin Deposition and Prolongs Survival in Neonatal Hyperoxic Lung Injury American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2007 | Pubmed ID: 17384081 Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Jul, 2007 | Pubmed ID: 17379851 Demonstration of Bacterial Cells and Glycocalyx in Biofilms on Human Tonsils Archives of Otolaryngology--head & Neck Surgery. Feb, 2007 | Pubmed ID: 17309977 Small Airways Dysfunction and Neutrophilic Inflammation in Bronchial Biopsies and BAL in COPD Chest. Jan, 2007 | Pubmed ID: 17218556 Exploring Host-pathogen Interactions at the Epithelial Surface: Application of Transcriptomics in Lung Biology American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2007 | Pubmed ID: 17041013 Epithelial Differentiation is a Determinant in the Production of Eotaxin-2 and -3 by Bronchial Epithelial Cells in Response to IL-4 and IL-13 Molecular Immunology. Feb, 2007 | Pubmed ID: 16740309 Adenovirus-specific CD4+ T Cell Clones Recognizing Endogenous Antigen Inhibit Viral Replication in Vitro Through Cognate Interaction Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17142788 The SERPINE2 Gene and Chronic Obstructive Pulmonary Disease American Journal of Human Genetics. Jul, 2006 | Pubmed ID: 16773582 The Antimicrobial Peptide LL-37 Enhances IL-8 Release by Human Airway Smooth Muscle Cells The Journal of Allergy and Clinical Immunology. Jun, 2006 | Pubmed ID: 16750994 Human Cathelicidin LL-37 is a Chemoattractant for Eosinophils and Neutrophils That Acts Via Formyl-peptide Receptors International Archives of Allergy and Immunology. 2006 | Pubmed ID: 16557028 A Molecular Signature of Epithelial Host Defense: Comparative Gene Expression Analysis of Cultured Bronchial Epithelial Cells and Keratinocytes BMC Genomics. Jan, 2006 | Pubmed ID: 16420688 Expression of Epidermal Growth Factors and Their Receptors in the Bronchial Epithelium of Subjects with Chronic Obstructive Pulmonary Disease American Journal of Clinical Pathology. Feb, 2006 | Pubmed ID: 16393673 Development of Novel LL-37 Derived Antimicrobial Peptides with LPS and LTA Neutralizing and Antimicrobial Activities for Therapeutic Application Peptides. Apr, 2006 | Pubmed ID: 16274847 Cytokine-dependent Proliferation of Human CD34+ Progenitor Cells in the Absence of Serum is Suppressed by Their Progeny's Production of Serine Proteinases Stem Cells (Dayton, Ohio). Feb, 2006 | Pubmed ID: 16109763 Effects of Cigarette Smoke Condensate on Proliferation and Wound Closure of Bronchial Epithelial Cells in Vitro: Role of Glutathione Respiratory Research. Nov, 2005 | Pubmed ID: 16309548 Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma American Journal of Respiratory and Critical Care Medicine. Oct, 2005 | Pubmed ID: 16085937 Host Defense Effector Molecules in Mucosal Secretions FEMS Immunology and Medical Microbiology. Aug, 2005 | Pubmed ID: 16051067 The Human Cathelicidin LL-37: a Multifunctional Peptide Involved in Infection and Inflammation in the Lung Pulmonary Pharmacology & Therapeutics. 2005 | Pubmed ID: 15939310 Eotaxin-2 and Eotaxin-3 Expression is Associated with Persistent Eosinophilic Bronchial Inflammation in Patients with Asthma After Allergen Challenge The Journal of Allergy and Clinical Immunology. Apr, 2005 | Pubmed ID: 15805998 Transcriptional Response of Bronchial Epithelial Cells to Pseudomonas Aeruginosa: Identification of Early Mediators of Host Defense Physiological Genomics. May, 2005 | Pubmed ID: 15701729 Interactions Between Neutrophil-derived Antimicrobial Peptides and Airway Epithelial Cells Journal of Leukocyte Biology. Apr, 2005 | Pubmed ID: 15591123 TGF-beta Differentially Regulates TH2 Cytokine-induced Eotaxin and Eotaxin-3 Release by Human Airway Smooth Muscle Cells The Journal of Allergy and Clinical Immunology. Oct, 2004 | Pubmed ID: 15480317 Bacterial Products Increase Expression of the Human Cathelicidin HCAP-18/LL-37 in Cultured Human Sinus Epithelial Cells FEMS Immunology and Medical Microbiology. Oct, 2004 | Pubmed ID: 15364108 Gene Expression Profile and Histopathology of Experimental Bronchopulmonary Dysplasia Induced by Prolonged Oxidative Stress Free Radical Biology & Medicine. Mar, 2004 | Pubmed ID: 14990357 Series Introduction: Innate Host Defense of the Respiratory Epithelium Journal of Leukocyte Biology. Jan, 2004 | Pubmed ID: 14612432 Neutrophil Defensins Enhance Lung Epithelial Wound Closure and Mucin Gene Expression in Vitro American Journal of Respiratory Cell and Molecular Biology. Feb, 2004 | Pubmed ID: 12871849 The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14662872 Rhinovirus Increases Human Beta-defensin-2 and -3 MRNA Expression in Cultured Bronchial Epithelial Cells FEMS Immunology and Medical Microbiology. Aug, 2003 | Pubmed ID: 12900056 Are Rhinovirus-induced Airway Responses in Asthma Aggravated by Chronic Allergen Exposure? American Journal of Respiratory and Critical Care Medicine. Nov, 2003 | Pubmed ID: 12893645 An Angiogenic Role for the Human Peptide Antibiotic LL-37/hCAP-18 The Journal of Clinical Investigation. Jun, 2003 | Pubmed ID: 12782669 Expression of Beta-defensin 1 and 2 MRNA by Human Monocytes, Macrophages and Dendritic Cells Immunology. Aug, 2002 | Pubmed ID: 12153515 World Congress on Lung Health and 10th ERS Annual Congress 30 August-3 September 2000, Florence, Italy Respiratory Research. 2000 | Pubmed ID: 11667983 Isolando Células Epiteliais Brônquicas de Tecido Pulmonar Ressecado para Biobanco e Estabelecendo Culturas de Interface Ar-Líquido Bem Diferenciadas Dennis K. Ninaber1, Anne M. van der Does1, Pieter S. Hiemstra1 1PulmoScience Laboratory, Department of Pulmonology, Leiden University Medical Center JoVE 65102 免疫与感染
Isolando Células Epiteliais Brônquicas de Tecido Pulmonar Ressecado para Biobanco e Estabelecendo Culturas de Interface Ar-Líquido Bem Diferenciadas Dennis K. Ninaber1, Anne M. van der Does1, Pieter S. Hiemstra1 1PulmoScience Laboratory, Department of Pulmonology, Leiden University Medical Center JoVE 65102 免疫与感染