Ralf Bartenschlager Department of Infectious Diseases, Molecular Virology Heidelberg University Biography Publications Institution JoVE Articles Ralf Bartenschlager has not added a biography. If you are Ralf Bartenschlager and would like to personalize this page please email our Author Liaison for assistance. Publications Novel Non-heteroarylpyrimidine (HAP) Capsid Assembly Modifiers Have a Different Mode of Action from HAPs in Vitro Antiviral Research. Jul, 2018 | Pubmed ID: 30031759 A Reverse Genetics System for Zika Virus Based on a Simple Molecular Cloning Strategy Viruses. 07, 2018 | Pubmed ID: 30002313 Semen Inhibits Zika Virus Infection of Cells and Tissues from the Anogenital Region Nature Communications. Jun, 2018 | Pubmed ID: 29880824 HCV Modifies EGF Signalling and Upregulates Production of CXCR2 Ligands: Role in Inflammation and Antiviral Immune Response Journal of Hepatology. Sep, 2018 | Pubmed ID: 29705238 Critical Challenges and Emerging Opportunities in Hepatitis C Virus Research in an Era of Potent Antiviral Therapy: Considerations for Scientists and Funding Agencies Virus Research. 03, 2018 | Pubmed ID: 29477639 Structural Studies of Self-Assembled Subviral Particles: Combining Cell-Free Expression with 110 kHz MAS NMR Spectroscopy Angewandte Chemie (International Ed. in English). Apr, 2018 | Pubmed ID: 29457857 Rewiring Cellular Networks by Members of the Flaviviridae Family Nature Reviews. Microbiology. Feb, 2018 | Pubmed ID: 29430005 HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon Gastroenterology. 05, 2018 | Pubmed ID: 29410097 Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles Journal of Virology. 02, 2018 | Pubmed ID: 29167346 Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis Journal of Virology. 01, 2018 | Pubmed ID: 29046459 Host-directed Therapies for Bacterial and Viral Infections Nature Reviews. Drug Discovery. Jan, 2018 | Pubmed ID: 28935918 Membrane Alterations Induced by Nonstructural Proteins of Human Norovirus PLoS Pathogens. Oct, 2017 | Pubmed ID: 29077760 Optimization of Substrate-Analogue Furin Inhibitors ChemMedChem. 12, 2017 | Pubmed ID: 29059503 Genome Packaging of Reovirus is Mediated by the Scaffolding Property of the Microtubule Network Cellular Microbiology. 12, 2017 | Pubmed ID: 28672089 Maturation of Secreted HCV Particles by Incorporation of Secreted ApoE Protects from Antibodies by Enhancing Infectivity Journal of Hepatology. Sep, 2017 | Pubmed ID: 28438690 Erratum for Roth Et Al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses" MBio. 04, 2017 | Pubmed ID: 28420740 Effects of NS2B-NS3 Protease and Furin Inhibition on West Nile and Dengue Virus Replication Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2017 | Pubmed ID: 28385094 A Novel Inhibitor IDPP Interferes with Entry and Egress of HCV by Targeting Glycoprotein E1 in a Genotype-Specific Manner Scientific Reports. 03, 2017 | Pubmed ID: 28333153 Immune Protection Against Reinfection with Nonprimate Hepacivirus Proceedings of the National Academy of Sciences of the United States of America. 03, 2017 | Pubmed ID: 28275093 Ultrastructural Characterization of Zika Virus Replication Factories Cell Reports. Feb, 2017 | Pubmed ID: 28249158 Novel Nucleoside Analogues Targeting HCV Replication Through an NS5A-dependent Inhibition Mechanism Chemical Biology & Drug Design. Sep, 2017 | Pubmed ID: 28245093 Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide SiRNA Screening Molecular Cell. Feb, 2017 | Pubmed ID: 28132841 Editorial: An Expanded View of Viruses FEMS Microbiology Reviews. 01, 2017 | Pubmed ID: 28087690 Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses MBio. 01, 2017 | Pubmed ID: 28074025 Peptide-Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27966962 TALEN/CRISPR-mediated Engineering of a Promoterless Anti-viral RNAi Hairpin into an Endogenous MiRNA Locus Nucleic Acids Research. 01, 2017 | Pubmed ID: 27614072 Tuning a Cellular Lipid Kinase Activity Adapts Hepatitis C Virus to Replication in Cell Culture Nature Microbiology. 12, 2016 | Pubmed ID: 27991882 The Quest for Host Targets to Combat Dengue Virus Infections Current Opinion in Virology. 10, 2016 | Pubmed ID: 27648486 Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award JAMA. Sep, 2016 | Pubmed ID: 27623041 Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses Cell Host & Microbe. Sep, 2016 | Pubmed ID: 27545046 Broad Neutralization of Hepatitis C Virus-resistant Variants by Civacir Hepatitis C Immunoglobulin Hepatology (Baltimore, Md.). 11, 2016 | Pubmed ID: 27531416 Endoplasmic Reticulum: The Favorite Intracellular Niche for Viral Replication and Assembly Viruses. 06, 2016 | Pubmed ID: 27338443 A Slow Maturation Process Renders Hepatitis B Virus Infectious Cell Host & Microbe. Jul, 2016 | Pubmed ID: 27321908 Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy PloS One. 2016 | Pubmed ID: 27281344 Reovirus Intermediate Subviral Particles Constitute a Strategy to Infect Intestinal Epithelial Cells by Exploiting TGF-β Dependent Pro-survival Signaling Cellular Microbiology. Dec, 2016 | Pubmed ID: 27279006 Cell-free Expression, Purification, and Membrane Reconstitution for NMR Studies of the Nonstructural Protein 4B from Hepatitis C Virus Journal of Biomolecular NMR. Jun, 2016 | Pubmed ID: 27233794 Geno2pheno[HCV] - A Web-based Interpretation System to Support Hepatitis C Treatment Decisions in the Era of Direct-Acting Antiviral Agents PloS One. 2016 | Pubmed ID: 27196673 Correlative Light and Electron Microscopy Methods for the Study of Virus-cell Interactions FEBS Letters. 07, 2016 | Pubmed ID: 27008928 Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family PloS One. 2016 | Pubmed ID: 26886748 Coordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5A PLoS Pathogens. Jan, 2016 | Pubmed ID: 26727512 Paradoxical Role of Antibodies in Dengue Virus Infections: Considerations for Prophylactic Vaccine Development Expert Review of Vaccines. 2016 | Pubmed ID: 26577689 Evidence That Hepatitis B Virus Replication in Mouse Cells is Limited by the Lack of a Host Cell Dependency Factor Journal of Hepatology. Mar, 2016 | Pubmed ID: 26576481 Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies Gastroenterology. Jan, 2016 | Pubmed ID: 26404951 Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave Annual Review of Virology. Nov, 2015 | Pubmed ID: 26958917 Viral Infection at High Magnification: 3D Electron Microscopy Methods to Analyze the Architecture of Infected Cells Viruses. Dec, 2015 | Pubmed ID: 26633469 Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus PLoS Pathogens. Nov, 2015 | Pubmed ID: 26588843 Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production Via Interaction with the Structural Proteins PLoS Pathogens. 2015 | Pubmed ID: 26562291 Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue Journal of Medicinal Chemistry. Dec, 2015 | Pubmed ID: 26562070 Phenylalanine and Phenylglycine Analogues As Arginine Mimetics in Dengue Protease Inhibitors Journal of Medicinal Chemistry. Oct, 2015 | Pubmed ID: 26367391 Functional Expression, Purification, Characterization, and Membrane Reconstitution of Non-structural Protein 2 from Hepatitis C Virus Protein Expression and Purification. Dec, 2015 | Pubmed ID: 26325423 Structural and Functional Properties of the Hepatitis C Virus P7 Viroporin Viruses. Aug, 2015 | Pubmed ID: 26258788 Alleviation of Off-target Effects from Vector-encoded ShRNAs Via Codelivered RNA Decoys Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26170322 NS5A Domain 1 and Polyprotein Cleavage Kinetics Are Critical for Induction of Double-Membrane Vesicles Associated with Hepatitis C Virus Replication MBio. Jul, 2015 | Pubmed ID: 26152585 Soraphen A: A Broad-spectrum Antiviral Natural Product with Potent Anti-hepatitis C Virus Activity Journal of Hepatology. Oct, 2015 | Pubmed ID: 26070407 Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor P62 Journal of Virology. Aug, 2015 | Pubmed ID: 26018155 Interferon-inducible Cholesterol-25-hydroxylase Restricts Hepatitis C Virus Replication Through Blockage of Membranous Web Formation Hepatology (Baltimore, Md.). Sep, 2015 | Pubmed ID: 25999047 A Combined Genetic-Proteomic Approach Identifies Residues Within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication Journal of Virology. Jul, 2015 | Pubmed ID: 25926641 Control of Temporal Activation of Hepatitis C Virus-induced Interferon Response by Domain 2 of Nonstructural Protein 5A Journal of Hepatology. Oct, 2015 | Pubmed ID: 25908268 Clearance of Persistent Hepatitis C Virus Infection in Humanized Mice Using a Claudin-1-targeting Monoclonal Antibody Nature Biotechnology. May, 2015 | Pubmed ID: 25798937 Identification of HNRNPK As Regulator of Hepatitis C Virus Particle Production PLoS Pathogens. Jan, 2015 | Pubmed ID: 25569684 Going Full Circle: Validation of P-body Dispersion in Hepatitis C Virus-infected Patients Journal of Hepatology. Apr, 2015 | Pubmed ID: 25559325 Novel Dengue Virus NS2B/NS3 Protease Inhibitors Antimicrobial Agents and Chemotherapy. Feb, 2015 | Pubmed ID: 25487800 Wheat Germ Cell-free Expression: Two Detergents with a Low Critical Micelle Concentration Allow for Production of Soluble HCV Membrane Proteins Protein Expression and Purification. Jan, 2015 | Pubmed ID: 25306874 Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land Cell Host & Microbe. Nov, 2014 | Pubmed ID: 25525790 Apolipoprotein E Likely Contributes to a Maturation Step of Infectious Hepatitis C Virus Particles and Interacts with Viral Envelope Glycoproteins Journal of Virology. Nov, 2014 | Pubmed ID: 25122793 The Lysine Methyltransferase SMYD3 Interacts with Hepatitis C Virus NS5A and is a Negative Regulator of Viral Particle Production Virology. Aug, 2014 | Pubmed ID: 25092459 Development of a High-throughput Pyrosequencing Assay for Monitoring Temporal Evolution and Resistance Associated Variant Emergence in the Hepatitis C Virus Protease Coding-region Antiviral Research. Oct, 2014 | Pubmed ID: 25057759 Characterization of the Mode of Action of a Potent Dengue Virus Capsid Inhibitor Journal of Virology. Oct, 2014 | Pubmed ID: 25056895 Membranous Replication Factories Induced by Plus-strand RNA Viruses Viruses. Jul, 2014 | Pubmed ID: 25054883 Daclatasvir-like Inhibitors of NS5A Block Early Biogenesis of Hepatitis C Virus-induced Membranous Replication Factories, Independent of RNA Replication Gastroenterology. Nov, 2014 | Pubmed ID: 25046163 Strategies to Inhibit Entry of HBV and HDV into Hepatocytes Gastroenterology. Jul, 2014 | Pubmed ID: 24768844 Heterologous Src Homology 4 Domains Support Membrane Anchoring and Biological Activity of HIV-1 Nef The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24706755 Inhibition of HCV Replication by Cyclophilin Antagonists is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation Gastroenterology. May, 2014 | Pubmed ID: 24486951 On the History of Hepatitis C Virus Cell Culture Systems Journal of Medicinal Chemistry. Mar, 2014 | Pubmed ID: 24164647 Thiazolidinone-peptide Hybrids As Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24083834 Robust RNAi Enhancement Via Human Argonaute-2 Overexpression from Plasmids, Viral Vectors and Cell Lines Nucleic Acids Research. Nov, 2013 | Pubmed ID: 24049077 Replication Vesicles Are Load- and Choke-points in the Hepatitis C Virus Lifecycle PLoS Pathogens. 2013 | Pubmed ID: 23990783 Interferon-stimulated Genes and Their Role in Controlling Hepatitis C Virus Journal of Hepatology. Dec, 2013 | Pubmed ID: 23933585 Morphological and Biochemical Characterization of the Membranous Hepatitis C Virus Replication Compartment Journal of Virology. Oct, 2013 | Pubmed ID: 23885072 Evidence for Novel Hepaciviruses in Rodents PLoS Pathogens. 2013 | Pubmed ID: 23818848 The Molecular and Structural Basis of Advanced Antiviral Therapy for Hepatitis C Virus Infection Nature Reviews. Microbiology. Jul, 2013 | Pubmed ID: 23748342 Analysis of Hepatitis C Virus Resistance to Silibinin in Vitro and in Vivo Points to a Novel Mechanism Involving Nonstructural Protein 4B Hepatology (Baltimore, Md.). Mar, 2013 | Pubmed ID: 23322644 Promotion of Hepatocellular Carcinoma by Hepatitis C Virus Digestive Diseases (Basel, Switzerland). 2012 | Pubmed ID: 23108300 Dynamic Oscillation of Translation and Stress Granule Formation Mark the Cellular Response to Virus Infection Cell Host & Microbe. Jul, 2012 | Pubmed ID: 22817989 Persistence of HCV in Quiescent Hepatic Cells Under Conditions of an Interferon-induced Antiviral Response Gastroenterology. Aug, 2012 | Pubmed ID: 22522091 Mutations That Alter Use of Hepatitis C Virus Cell Entry Factors Mediate Escape from Neutralizing Antibodies Gastroenterology. Jul, 2012 | Pubmed ID: 22503792 New Targets for Antiviral Therapy of Chronic Hepatitis C Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2012 | Pubmed ID: 22212566 높은 콘텐츠 휴대 전화 스크린의 분석에서 개별 셀 인구 컨텍스트를 정상화 BMC Bioinformatics. 2011 | Pubmed ID: 22185194 Exploitation of Cellular Pathways by Dengue Virus Current Opinion in Microbiology. Aug, 2011 | Pubmed ID: 21798792 Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles Gastroenterology. Sep, 2011 | Pubmed ID: 21699799 신호 인지 력과 타고 난 면역 센서 Retinoic 산을 유도할 수 있는 유전자에 의해 통합의 분자 메커니즘-난 (유 정-나) The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21659521 Hepatitis C Virus and Host Cell Lipids: an Intimate Connection RNA Biology. Mar-Apr, 2011 | Pubmed ID: 21593584 NS4B Self-interaction Through Conserved C-terminal Elements is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes Journal of Virology. Jul, 2011 | Pubmed ID: 21543474 모집 및 C 형 간염 바이러스에 의해 지질 키 니 아 제 활성화 NS5A 막 복제 구획의 무결성을 위해 필수적 이다 Cell Host & Microbe. Jan, 2011 | Pubmed ID: 21238945 Assembly of Infectious Hepatitis C Virus Particles Trends in Microbiology. Feb, 2011 | Pubmed ID: 21146993 Biochemical and Morphological Properties of Hepatitis C Virus Particles and Determination of Their Lipidome The Journal of Biological Chemistry. Jan, 2011 | Pubmed ID: 21056986 New Insights into Structure and Replication of the Hepatitis C Virus and Clinical Implications Seminars in Liver Disease. Nov, 2010 | Pubmed ID: 20960374 상호 빛 전자 현미경 검사 법 (클레 멘 타인) 추적 하 고 바이러스 성 단백질을 이미징 관련 Cryo 움직일 셀 구조 Rachel Santarella-Mellwig1, Uta Haselmann2, Nicole L. Schieber1, Paul Walther3, Yannick Schwab1, Claude Antony1, Ralf Bartenschlager2,4, Inés Romero-Brey2 1European Molecular Biology Laboratory, 2Department of Infectious Diseases, Molecular Virology, Heidelberg University, 3Central Facility for Electron Microscopy, Ulm University, 4Heidelberg Partner Site, German Center for Infection Research JoVE 58154 生物工程
상호 빛 전자 현미경 검사 법 (클레 멘 타인) 추적 하 고 바이러스 성 단백질을 이미징 관련 Cryo 움직일 셀 구조 Rachel Santarella-Mellwig1, Uta Haselmann2, Nicole L. Schieber1, Paul Walther3, Yannick Schwab1, Claude Antony1, Ralf Bartenschlager2,4, Inés Romero-Brey2 1European Molecular Biology Laboratory, 2Department of Infectious Diseases, Molecular Virology, Heidelberg University, 3Central Facility for Electron Microscopy, Ulm University, 4Heidelberg Partner Site, German Center for Infection Research JoVE 58154 生物工程
