Stephen C. Pflugfelder Cullen Eye Institute, Department of Ophthalmology Baylor College of Medicine Biography Publications Institution JoVE Articles Stephen C. Pflugfelder has not added a biography. If you are Stephen C. Pflugfelder and would like to personalize this page please email our Author Liaison for assistance. Publications Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca Translational Vision Science & Technology. Jun, 2023 | Pubmed ID: 37310735 Dry Eye Disease and Blinking Behaviors: A Narrative Review of Methodologies for Measuring Blink Dynamics and Inducing Blink Response The Ocular Surface. May, 2023 | Pubmed ID: 37257694 Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 Nm Laser International Journal of Molecular Sciences. Mar, 2023 | Pubmed ID: 36982810 Clinical Diagnosis and Management of Demodex Blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH) Eye (London, England). Mar, 2023 | Pubmed ID: 36964261 Non-invasive and Objective Tear Film Breakup Detection on Interference Color Images Using Convolutional Neural Networks PloS One. 2023 | Pubmed ID: 36913382 Delphi Panel Consensus Regarding Current Clinical Practice Management Options for Clinical Ophthalmology (Auckland, N.Z.). 2023 | Pubmed ID: 36875531 Quantitative Assessment of Botulinum Toxin Injection on Blink Rate in Blepharospasm Orbit (Amsterdam, Netherlands). Dec, 2022 | Pubmed ID: 36484152 Imbalanced IL-37/TNF-α/CTSS Signaling Disrupts Corneal Epithelial Barrier in a Dry Eye Model in Vitro The Ocular Surface. Oct, 2022 | Pubmed ID: 36208723 Nicotinic Acetylcholine Receptor Stimulation: A New Approach for Stimulating Tear Secretion in Dry Eye Disease The Ocular Surface. Jul, 2022 | Pubmed ID: 35550851 A Multicenter Report of the Use of Plasma Rich in Growth Factors (PRGF) for the Treatment of Patients with Ocular Surface Diseases in North America The Ocular Surface. Jul, 2022 | Pubmed ID: 35489588 Author Correction: Gut-derived Butyrate Suppresses Ocular Surface Inflammation Scientific Reports. Apr, 2022 | Pubmed ID: 35449441 IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse Frontiers in Medicine. 2022 | Pubmed ID: 35402439 Single-cell Transcriptional Profiling of Murine Conjunctival Immune Cells Reveals Distinct Populations Expressing Homeostatic and Regulatory Genes Mucosal Immunology. Apr, 2022 | Pubmed ID: 35361907 Gut Microbiota From Sjögren Syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice Frontiers in Medicine. 2022 | Pubmed ID: 35355610 Gut-derived Butyrate Suppresses Ocular Surface Inflammation Scientific Reports. Mar, 2022 | Pubmed ID: 35296712 Combined Therapy of Ocular Surface Disease with Plasma Rich in Growth Factors and Scleral Contact Lenses The Ocular Surface. Jan, 2022 | Pubmed ID: 34537416 IL-36α/IL-36RA/IL-38 Signaling Mediates Inflammation and Barrier Disruption in Human Corneal Epithelial Cells Under Hyperosmotic Stress The Ocular Surface. Oct, 2021 | Pubmed ID: 34428579 Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca Frontiers in Immunology. 2021 | Pubmed ID: 34349764 Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis Frontiers in Immunology. 2021 | Pubmed ID: 34305940 Dry Eye Disease Flares: A Rapid Evidence Assessment The Ocular Surface. Oct, 2021 | Pubmed ID: 34303844 Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus Investigative Ophthalmology & Visual Science. Jul, 2021 | Pubmed ID: 34297801 Video Viewing Blink Rate in Normal and Dry Eyes Eye & Contact Lens. Aug, 2021 | Pubmed ID: 33900215 Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye American Journal of Ophthalmology. Jul, 2021 | Pubmed ID: 33571473 Retinoid Regulation of Ocular Surface Innate Inflammation International Journal of Molecular Sciences. Jan, 2021 | Pubmed ID: 33499199 Single-cell Transcriptomics Identifies Limbal Stem Cell Population and Cell Types Mapping Its Differentiation Trajectory in Limbal Basal Epithelium of Human Cornea The Ocular Surface. Apr, 2021 | Pubmed ID: 33388438 Defining Dry Eye from a Clinical Perspective International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33291796 Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro International Journal of Molecular Sciences. Nov, 2020 | Pubmed ID: 33255884 Rapamycin Eyedrops Increased CD4Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface International Journal of Molecular Sciences. Nov, 2020 | Pubmed ID: 33255287 Unilateral Pediatric Neurotrophic Keratitis Due to Congenital Left Trigeminal Nerve Aplasia with PROSE (prosthetic Replacement of the Ocular Surface Ecosystem) Treatment American Journal of Ophthalmology Case Reports. Dec, 2020 | Pubmed ID: 33094195 Inflammatory Basis for Dry Eye Disease Flares Experimental Eye Research. Dec, 2020 | Pubmed ID: 33039458 The Cornea in Keratoconjunctivitis Sicca Experimental Eye Research. Dec, 2020 | Pubmed ID: 33038387 Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress Investigative Ophthalmology & Visual Science. Aug, 2020 | Pubmed ID: 32785678 Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Nov, 2020 | Pubmed ID: 32721249 Goblet Cells Promote Tolerance Induction in the Conjunctiva Mucosal Immunology. Sep, 2020 | Pubmed ID: 32616838 Biological Functions of Tear Film Experimental Eye Research. Aug, 2020 | Pubmed ID: 32561483 IL-33/ST2/IL-9/IL-9R Signaling Disrupts Ocular Surface Barrier in Allergic Inflammation Mucosal Immunology. Nov, 2020 | Pubmed ID: 32358573 Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC Scientific Reports. Feb, 2020 | Pubmed ID: 32076085 Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions International Journal of Molecular Sciences. Jan, 2020 | Pubmed ID: 31963817 Immune - Goblet Cell Interaction in the Conjunctiva The Ocular Surface. Apr, 2020 | Pubmed ID: 31953222 The Gut-eye-lacrimal Gland-microbiome Axis in Sjögren Syndrome The Ocular Surface. Apr, 2020 | Pubmed ID: 31644955 Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial Ophthalmology. Jan, 2020 | Pubmed ID: 31585826 Ocular Complications of Atopic Dermatitis Cutis. Sep, 2019 | Pubmed ID: 31675394 Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide Investigative Ophthalmology & Visual Science. Oct, 2019 | Pubmed ID: 31618426 Topical Cyclosporine A Therapy for Dry Eye Syndrome The Cochrane Database of Systematic Reviews. Sep, 2019 | Pubmed ID: 31517988 Short Ragweed Pollen Promotes M2 Macrophage Polarization Via TSLP/TSLPR/OX40L Signaling in Allergic Inflammation Mucosal Immunology. 09, 2019 | Pubmed ID: 31350466 Age-associated Antigen-presenting Cell Alterations Promote Dry-eye Inducing Th1 Cells Mucosal Immunology. Jul, 2019 | Pubmed ID: 30696983 IL-27 Signaling Deficiency Develops Th17-enhanced Th2-dominant Inflammation in Murine Allergic Conjunctivitis Model Allergy. May, 2019 | Pubmed ID: 30515838 Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome International Journal of Molecular Sciences. Nov, 2018 | Pubmed ID: 30513621 Bilateral Candida Parapsilosis Infiltration of Nonhealing Indolent Epithelial Defects in a Diabetic Patient with Neurotrophic Keratopathy Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie. Dec, 2018 | Pubmed ID: 30502998 Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30223431 Goblet Cell-produced Retinoic Acid Suppresses CD86 Expression and IL-12 Production in Bone Marrow-derived Cells International Immunology. Sep, 2018 | Pubmed ID: 30010888 Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Sep, 2018 | Pubmed ID: 29958030 Protective Role of Commensal Bacteria in Sjögren Syndrome Journal of Autoimmunity. Sep, 2018 | Pubmed ID: 29934134 Near-infrared Laser Thermal Conjunctivoplasty Scientific Reports. Mar, 2018 | Pubmed ID: 29497112 Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice International Journal of Molecular Sciences. Feb, 2018 | Pubmed ID: 29438346 Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) Scleral Lens on Visual Acuity for Corneal Irregularity and Ocular Surface Disease The Ocular Surface. Apr, 2018 | Pubmed ID: 29425812 Goblet Cell Loss Abrogates Ocular Surface Immune Tolerance JCI Insight. Feb, 2018 | Pubmed ID: 29415888 Reduced Intraepithelial Corneal Nerve Density and Sensitivity Accompany Desiccating Stress and Aging in C57BL/6 Mice Experimental Eye Research. Apr, 2018 | Pubmed ID: 29407221 The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research Ophthalmology. Nov, 2017 | Pubmed ID: 29055361 Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human Scientific Reports. Jul, 2017 | Pubmed ID: 28701781 Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease International Journal of Molecular Sciences. May, 2017 | Pubmed ID: 28475124 Evolving Risk Factors and Antibiotic Sensitivity Patterns for Microbial Keratitis at a Large County Hospital The British Journal of Ophthalmology. Nov, 2017 | Pubmed ID: 28336675 Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation American Journal of Ophthalmology. May, 2017 | Pubmed ID: 28302532 Long-term Outcomes of Ciliary Sulcus Versus Capsular Bag Fixation of Intraocular Lenses in Children: An Ultrasound Biomicroscopy Study PloS One. 2017 | Pubmed ID: 28301497 What We Have Learned From Animal Models of Dry Eye International Ophthalmology Clinics. 2017 | Pubmed ID: 28282318 Tear Volume-based Diagnostic Classification for Tear Dysfunction International Ophthalmology Clinics. 2017 | Pubmed ID: 28282310 Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn International Journal of Molecular Sciences. Mar, 2017 | Pubmed ID: 28273882 Mitochondrial DNA Oxidation Induces Imbalanced Activity of NLRP3/NLRP6 Inflammasomes by Activation of Caspase-8 and BRCC36 in Dry Eye Journal of Autoimmunity. Jun, 2017 | Pubmed ID: 28238526 LFA-1/ICAM-1 Interaction As a Therapeutic Target in Dry Eye Disease Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. 2017 | Pubmed ID: 27906544 Age-related Spontaneous Lacrimal Keratoconjunctivitis is Accompanied by Dysfunctional T Regulatory Cells Mucosal Immunology. May, 2017 | Pubmed ID: 27706128 Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation Scientific Reports. Oct, 2016 | Pubmed ID: 27796360 Interferon-gamma Deficiency Protects Against Aging-related Goblet Cell Loss Oncotarget. Oct, 2016 | Pubmed ID: 27623073 Synergistic Cysteamine Delivery Nanowafer As an Efficacious Treatment Modality for Corneal Cystinosis Molecular Pharmaceutics. Oct, 2016 | Pubmed ID: 27571217 Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye Investigative Ophthalmology & Visual Science. Jun, 2016 | Pubmed ID: 27327581 Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model Investigative Ophthalmology & Visual Science. May, 2016 | Pubmed ID: 27136463 Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome Scientific Reports. Apr, 2016 | Pubmed ID: 27087247 Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells As a Cause of Mucin Deficiency in Sjögren Syndrome The American Journal of Pathology. Jun, 2016 | Pubmed ID: 27085137 MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions Journal of Cellular Physiology. Nov, 2016 | Pubmed ID: 26923552 Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease The Ocular Surface. Apr, 2016 | Pubmed ID: 26882981 Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease The Ocular Surface. Apr, 2016 | Pubmed ID: 26807723 Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye The Ocular Surface. Apr, 2016 | Pubmed ID: 26772899 Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation Via Anti-oxidative Pathway Scientific Reports. Jan, 2016 | Pubmed ID: 26762881 Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease The Ocular Surface. Jan, 2016 | Pubmed ID: 26549248 Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss Investigative Ophthalmology & Visual Science. Nov, 2015 | Pubmed ID: 26618646 Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye PloS One. 2015 | Pubmed ID: 26402857 Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model Investigative Ophthalmology & Visual Science. Sep, 2015 | Pubmed ID: 26348638 Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. Aug, 2015 | Pubmed ID: 26284556 Corneal Sensitivity in Tear Dysfunction and Its Correlation With Clinical Parameters and Blink Rate American Journal of Ophthalmology. Nov, 2015 | Pubmed ID: 26255576 Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas Investigative Ophthalmology & Visual Science. Jul, 2015 | Pubmed ID: 26225631 Effects of Azithromycin on Gene Expression Profiles of Proinflammatory and Anti-inflammatory Mediators in the Eyelid Margin and Conjunctiva of Patients with Meibomian Gland Disease JAMA Ophthalmology. Oct, 2015 | Pubmed ID: 26204109 Dexamethasone Nanowafer As an Effective Therapy for Dry Eye Disease Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2015 | Pubmed ID: 26184051 IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells Investigative Ophthalmology & Visual Science. Jul, 2015 | Pubmed ID: 26132778 A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida Albicans by Producing Peptidoglycan Recognition Proteins PloS One. 2015 | Pubmed ID: 26039076 Oxidative Stress Markers Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells PloS One. 2015 | Pubmed ID: 26024535 Altered Balance of Interleukin-13/interferon-gamma Contributes to Lacrimal Gland Destruction and Secretory Dysfunction in CD25 Knockout Model of Sjögren's Syndrome Arthritis Research & Therapy. Mar, 2015 | Pubmed ID: 25889094 Clinical Guidelines for Management of Dry Eye Associated with Sjögren Disease The Ocular Surface. Apr, 2015 | Pubmed ID: 25881996 Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease American Journal of Ophthalmology. Jul, 2015 | Pubmed ID: 25868759 Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease Archivum Immunologiae Et Therapiae Experimentalis. Aug, 2015 | Pubmed ID: 25772203 Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction Investigative Ophthalmology & Visual Science. Apr, 2015 | Pubmed ID: 25758816 Unique Expression Pattern and Functional Role of Periostin in Human Limbal Stem Cells PloS One. 2015 | Pubmed ID: 25658308 Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy ACS Nano. Feb, 2015 | Pubmed ID: 25585134 Effects of L-carnitine, Erythritol and Betaine on Pro-inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress Current Eye Research. Jul, 2015 | Pubmed ID: 25271595 Osmoprotectants Suppress the Production and Activity of Matrix Metalloproteinases Induced by Hyperosmolarity in Primary Human Corneal Epithelial Cells Molecular Vision. 2014 | Pubmed ID: 25352733 Desiccating Stress-induced Chemokine Expression in the Epithelium is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye Journal of Immunology (Baltimore, Md. : 1950). Nov, 2014 | Pubmed ID: 25288568 Treatment of Blepharitis: Recent Clinical Trials The Ocular Surface. Oct, 2014 | Pubmed ID: 25284773 Effect of Loteprednol Etabonate 0.5% on Initiation of Dry Eye Treatment with Topical Cyclosporine 0.05% Eye & Contact Lens. Sep, 2014 | Pubmed ID: 25083776 Mucosal Environmental Sensors in the Pathogenesis of Dry Eye Expert Review of Clinical Immunology. Sep, 2014 | Pubmed ID: 25075545 Complications Related to a Cosmetic Eye-whitening Procedure American Journal of Ophthalmology. Nov, 2014 | Pubmed ID: 25072832 Human Corneal Epithelial Cells Produce Antimicrobial Peptides LL-37 and β-defensins in Response to Heat-killed Candida Albicans Ophthalmic Research. 2014 | Pubmed ID: 24662332 New Testing Options for Diagnosing and Grading Dry Eye Disease American Journal of Ophthalmology. Jun, 2014 | Pubmed ID: 24631478 What Causes Dryness in Sjögren's Syndrome Patients and How Can It Be Targeted? Expert Review of Clinical Immunology. Apr, 2014 | Pubmed ID: 24564508 A Potential Link Between Bacterial Pathogens and Allergic Conjunctivitis by Dendritic Cells Experimental Eye Research. Mar, 2014 | Pubmed ID: 24486456 Effect of Desiccating Stress on Mouse Meibomian Gland Function The Ocular Surface. Jan, 2014 | Pubmed ID: 24439047 Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice The American Journal of Pathology. Mar, 2014 | Pubmed ID: 24389165 Atopic Keratoconjunctivitis: A Review Journal of the American Academy of Dermatology. Mar, 2014 | Pubmed ID: 24342754 Topical Interferon-gamma Neutralization Prevents Conjunctival Goblet Cell Loss in Experimental Murine Dry Eye Experimental Eye Research. Jan, 2014 | Pubmed ID: 24315969 Tear Meniscus Dimensions in Tear Dysfunction and Their Correlation with Clinical Parameters American Journal of Ophthalmology. Feb, 2014 | Pubmed ID: 24315297 In Vivo Confocal Microscopy of the Ocular Surface: from Bench to Bedside Current Eye Research. Mar, 2014 | Pubmed ID: 24215436 Chemokine Receptors CCR6 and CXCR3 Are Necessary for CD4(+) T Cell Mediated Ocular Surface Disease in Experimental Dry Eye Disease PloS One. 2013 | Pubmed ID: 24223818 T Helper Cytokines in Dry Eye Disease Experimental Eye Research. Dec, 2013 | Pubmed ID: 24012834 Dendritic Cell-derived Thrombospondin-1 is Critical for the Generation of the Ocular Surface Th17 Response to Desiccating Stress Journal of Leukocyte Biology. Dec, 2013 | Pubmed ID: 23983225 Long-term Supplementation With N-6 and N-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial Cornea. Oct, 2013 | Pubmed ID: 23884332 A Novel Interleukin 33/ST2 Signaling Regulates Inflammatory Response in Human Corneal Epithelium PloS One. 2013 | Pubmed ID: 23585867 Factors Predicting the Ocular Surface Response to Desiccating Environmental Stress Investigative Ophthalmology & Visual Science. May, 2013 | Pubmed ID: 23572103 Patient Ocular Conditions and Clinical Outcomes Using a PROSE Scleral Device Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association. Aug, 2013 | Pubmed ID: 23499361 Toll-like Receptor Expression and Activation in Mice with Experimental Dry Eye Investigative Ophthalmology & Visual Science. Feb, 2013 | Pubmed ID: 23372055 Dry Eye As a Mucosal Autoimmune Disease International Reviews of Immunology. Feb, 2013 | Pubmed ID: 23360156 PROSE Therapy Used to Minimize Corneal Trauma in Patients with Corneal Epithelial Defects American Journal of Ophthalmology. Apr, 2013 | Pubmed ID: 23218704 Morphologic Alterations of the Palpebral Conjunctival Epithelium in a Dry Eye Model Cornea. Apr, 2013 | Pubmed ID: 23146932 Increasing Prevalence and Severity of Conjunctivochalasis with Aging Detected by Anterior Segment Optical Coherence Tomography American Journal of Ophthalmology. Feb, 2013 | Pubmed ID: 23036571 A Native-like Corneal Construct Using Donor Corneal Stroma for Tissue Engineering PloS One. 2012 | Pubmed ID: 23166715 Deletion of Interferon-γ Delays Onset and Severity of Dacryoadenitis in CD25KO Mice Arthritis Research & Therapy. Nov, 2012 | Pubmed ID: 23116218 Identification of Human Fibroblast Cell Lines As a Feeder Layer for Human Corneal Epithelial Regeneration PloS One. 2012 | Pubmed ID: 22723892 NK Cells Promote Th-17 Mediated Corneal Barrier Disruption in Dry Eye PloS One. 2012 | Pubmed ID: 22590618 Botulinum Toxin Injection for the Management of Refractory Filamentary Keratitis Archives of Ophthalmology (Chicago, Ill. : 1960). Apr, 2012 | Pubmed ID: 22491914 Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease Investigative Ophthalmology & Visual Science. Apr, 2012 | Pubmed ID: 22395876 Resolvin E1 (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye Cornea. Nov, 2012 | Pubmed ID: 22257864 Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells Stem Cells (Dayton, Ohio). Jan, 2012 | Pubmed ID: 22232078 Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease Under Experimental Murine Dry Eye Journal of Clinical & Experimental Ophthalmology. Nov, 2011 | Pubmed ID: 23560247 Disruption of TGF-β Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca PloS One. 2011 | Pubmed ID: 22194977 Challenges in the Clinical Measurement of Ocular Surface Disease in Glaucoma Patients Clinical Ophthalmology (Auckland, N.Z.). 2011 | Pubmed ID: 22125404 Tear Dysfunction and the Cornea: LXVIII Edward Jackson Memorial Lecture American Journal of Ophthalmology. Dec, 2011 | Pubmed ID: 22019306 Desiccating Stress Induces CD4+ T-cell-mediated Sjögren's Syndrome-like Corneal Epithelial Apoptosis Via Activation of the Extrinsic Apoptotic Pathway by Interferon-γ The American Journal of Pathology. Oct, 2011 | Pubmed ID: 21843497 Short Ragweed Pollen Triggers Allergic Inflammation Through Toll-like Receptor 4-dependent Thymic Stromal Lymphopoietin/OX40 Ligand/OX40 Signaling Pathways The Journal of Allergy and Clinical Immunology. Dec, 2011 | Pubmed ID: 21820713 TLR-mediated Induction of Pro-allergic Cytokine IL-33 in Ocular Mucosal Epithelium The International Journal of Biochemistry & Cell Biology. Sep, 2011 | Pubmed ID: 21684348 Interferon-γ Exacerbates Dry Eye-induced Apoptosis in Conjunctiva Through Dual Apoptotic Pathways Investigative Ophthalmology & Visual Science. Aug, 2011 | Pubmed ID: 21474767 Entrapment of Conjunctival Goblet Cells by Desiccation-induced Cornification Investigative Ophthalmology & Visual Science. Jun, 2011 | Pubmed ID: 21421863 The β-catenin/Tcf4/survivin Signaling Maintains a Less Differentiated Phenotype and High Proliferative Capacity of Human Corneal Epithelial Progenitor Cells The International Journal of Biochemistry & Cell Biology. May, 2011 | Pubmed ID: 21292023 Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland Investigative Ophthalmology & Visual Science. May, 2011 | Pubmed ID: 21273534 The Impact of the Boston Ocular Surface Prosthesis on Wavefront Higher-order Aberrations American Journal of Ophthalmology. Apr, 2011 | Pubmed ID: 21269603 Noninvasive Assessment of Tear Stability with the Tear Stability Analysis System in Tear Dysfunction Patients Investigative Ophthalmology & Visual Science. Jan, 2011 | Pubmed ID: 20631241 An Immunoprotective Privilege of Corneal Epithelial Stem Cells Against Th17 Inflammatory Stress by Producing Glial Cell-derived Neurotrophic Factor Stem Cells (Dayton, Ohio). Dec, 2010 | Pubmed ID: 20936708 Anterior Segment Optical Coherence Tomography: a Diagnostic Instrument for Conjunctivochalasis American Journal of Ophthalmology. Dec, 2010 | Pubmed ID: 20869039 The Successful Use of Boston Ocular Surface Prosthesis in the Treatment of Persistent Corneal Epithelial Defect After Herpes Zoster Ophthalmicus Cornea. Dec, 2010 | Pubmed ID: 20847682 Post-LASIK Tear Dysfunction and Dysesthesia The Ocular Surface. Jul, 2010 | Pubmed ID: 20712970 Spontaneous Autoimmune Dacryoadenitis in Aged CD25KO Mice The American Journal of Pathology. Aug, 2010 | Pubmed ID: 20566743 Evaluation of the Transforming Growth Factor-beta Activity in Normal and Dry Eye Human Tears by CCL-185 Cell Bioassay Cornea. Sep, 2010 | Pubmed ID: 20539212 Suppressive Effects of Azithromycin on Zymosan-induced Production of Proinflammatory Mediators by Human Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. Nov, 2010 | Pubmed ID: 20538995 Altered Morphology and Function of the Lacrimal Functional Unit in Protein Kinase C{alpha} Knockout Mice Investigative Ophthalmology & Visual Science. Nov, 2010 | Pubmed ID: 20505191 Potential Localization of Putative Stem/progenitor Cells in Human Bulbar Conjunctival Epithelium Journal of Cellular Physiology. Oct, 2010 | Pubmed ID: 20458737 Molecular Signatures and Biological Pathway Profiles of Human Corneal Epithelial Progenitor Cells The International Journal of Biochemistry & Cell Biology. Jul, 2010 | Pubmed ID: 20363357 Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues Through a Dendritic Cell-mediated Pathway Investigative Ophthalmology & Visual Science. Jun, 2010 | Pubmed ID: 20130281 TSLP and Downstream Molecules in Experimental Mouse Allergic Conjunctivitis Investigative Ophthalmology & Visual Science. Jun, 2010 | Pubmed ID: 20107175 Age-related T-cell Cytokine Profile Parallels Corneal Disease Severity in Sjogren's Syndrome-like Keratoconjunctivitis Sicca in CD25KO Mice Rheumatology (Oxford, England). Feb, 2010 | Pubmed ID: 20007286 Corneal Nerve Regeneration in Neurotrophic Keratopathy Following Autologous Plasma Therapy The British Journal of Ophthalmology. May, 2010 | Pubmed ID: 19965821 Expression of CXCL9, -10, -11, and CXCR3 in the Tear Film and Ocular Surface of Patients with Dry Eye Syndrome Investigative Ophthalmology & Visual Science. Feb, 2010 | Pubmed ID: 19850844 Association Between High Tear Epidermal Growth Factor Levels and Corneal Subepithelial Fibrosis in Dry Eye Conditions Investigative Ophthalmology & Visual Science. Feb, 2010 | Pubmed ID: 19815739 Toll-like Receptors Mediate Induction of Peptidoglycan Recognition Proteins in Human Corneal Epithelial Cells Experimental Eye Research. Jan, 2010 | Pubmed ID: 19799901 Induction of Th17 Differentiation by Corneal Epithelial-derived Cytokines Journal of Cellular Physiology. Jan, 2010 | Pubmed ID: 19746420 Essential Role for C-Jun N-terminal Kinase 2 in Corneal Epithelial Response to Desiccating Stress Archives of Ophthalmology (Chicago, Ill. : 1960). Dec, 2009 | Pubmed ID: 20008718 Cleavage of Functional IL-2 Receptor Alpha Chain (CD25) from Murine Corneal and Conjunctival Epithelia by MMP-9 Journal of Inflammation (London, England). Oct, 2009 | Pubmed ID: 19878594 Corneal Epithelial Opacity in Dysfunctional Tear Syndrome American Journal of Ophthalmology. Sep, 2009 | Pubmed ID: 19541283 Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome Investigative Ophthalmology & Visual Science. Jul, 2009 | Pubmed ID: 19255163 Human Corneal Epithelium-derived Thymic Stromal Lymphopoietin Links the Innate and Adaptive Immune Responses Via TLRs and Th2 Cytokines Investigative Ophthalmology & Visual Science. Jun, 2009 | Pubmed ID: 19151401 Tear Cytokine Profiles in Dysfunctional Tear Syndrome American Journal of Ophthalmology. Feb, 2009 | Pubmed ID: 18992869 Glial Cell-derived Neurotrophic Factor Gene Delivery Enhances Survival of Human Corneal Epithelium in Culture and the Overexpression of GDNF in Bioengineered Constructs Experimental Eye Research. Dec, 2008 | Pubmed ID: 18938159 Epithelial-immune Cell Interaction in Dry Eye Cornea. Sep, 2008 | Pubmed ID: 18813079 Effects of Contact Lens Multipurpose Solutions on Human Corneal Epithelial Survival and Barrier Function Eye & Contact Lens. Sep, 2008 | Pubmed ID: 18779668 Desiccating Stress Decreases Apical Corneal Epithelial Cell Size--modulation by the Metalloproteinase Inhibitor Doxycycline Cornea. Sep, 2008 | Pubmed ID: 18724157 Effects of Osmoprotectants on Hyperosmolar Stress in Cultured Human Corneal Epithelial Cells Cornea. Jun, 2008 | Pubmed ID: 18520508 Prevalence, Burden, and Pharmacoeconomics of Dry Eye Disease The American Journal of Managed Care. Apr, 2008 | Pubmed ID: 18452369 Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-beta2 Production Cornea. Jan, 2008 | Pubmed ID: 18245969 Hyperosmolarity-induced Cornification of Human Corneal Epithelial Cells is Regulated by JNK MAPK Investigative Ophthalmology & Visual Science. Feb, 2008 | Pubmed ID: 18234997 Bilateral Acanthamoeba Keratitis American Journal of Ophthalmology. Feb, 2008 | Pubmed ID: 18222188 Desiccating Environmental Stress Exacerbates Autoimmune Lacrimal Keratoconjunctivitis in Non-obese Diabetic Mice Journal of Autoimmunity. Jun, 2008 | Pubmed ID: 17988834 Nerve Growth Factor and Its Receptor TrkA Serve As Potential Markers for Human Corneal Epithelial Progenitor Cells Experimental Eye Research. Jan, 2008 | Pubmed ID: 17980361 Patterned Expression of Neurotrophic Factors and Receptors in Human Limbal and Corneal Regions Molecular Vision. Oct, 2007 | Pubmed ID: 17982417 Future Directions in Therapeutic Interventions for Conjunctival Inflammatory Disorders Current Opinion in Allergy and Clinical Immunology. Oct, 2007 | Pubmed ID: 17873588 Strain-related Cytokine Profiles on the Murine Ocular Surface in Response to Desiccating Stress Cornea. Jun, 2007 | Pubmed ID: 17525655 Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress Investigative Ophthalmology & Visual Science. Jun, 2007 | Pubmed ID: 17525185 Dry Eye-induced Conjunctival Epithelial Squamous Metaplasia is Modulated by Interferon-gamma Investigative Ophthalmology & Visual Science. Jun, 2007 | Pubmed ID: 17525184 Hyperosmolarity-induced Apoptosis in Human Corneal Epithelial Cells is Mediated by Cytochrome C and MAPK Pathways Cornea. May, 2007 | Pubmed ID: 17457195 Prominent Corneal Nerves in a Patient with Multiple Myeloma Cornea. Feb, 2007 | Pubmed ID: 17251817 Effect of Topical Ophthalmic Epinastine and Olopatadine on Tear Volume in Mice Eye & Contact Lens. Dec, 2006 | Pubmed ID: 17099387 Integrating Restasis into the Management of Dry Eye International Ophthalmology Clinics. 2006 | Pubmed ID: 17060796 Transglutaminase Participates in UVB-induced Cell Death Pathways in Human Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. Oct, 2006 | Pubmed ID: 17003418 Targeted Inhibition of P57 and P15 Blocks Transforming Growth Factor Beta-inhibited Proliferation of Primary Cultured Human Limbal Epithelial Cells Molecular Vision. Aug, 2006 | Pubmed ID: 16943770 Desiccating Stress Stimulates Expression of Matrix Metalloproteinases by the Corneal Epithelium Investigative Ophthalmology & Visual Science. Aug, 2006 | Pubmed ID: 16877394 Apical Corneal Barrier Disruption in Experimental Murine Dry Eye is Abrogated by Methylprednisolone and Doxycycline Investigative Ophthalmology & Visual Science. Jul, 2006 | Pubmed ID: 16799024 Improved Transduction of Human Corneal Epithelial Progenitor Cells with Cell-targeting Adenoviral Vectors Experimental Eye Research. Oct, 2006 | Pubmed ID: 16793039 Corticosteroid and Doxycycline Suppress MMP-9 and Inflammatory Cytokine Expression, MAPK Activation in the Corneal Epithelium in Experimental Dry Eye Experimental Eye Research. Sep, 2006 | Pubmed ID: 16643899 Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium Investigative Ophthalmology & Visual Science. May, 2006 | Pubmed ID: 16639001 The Incidence and Risk Factors for Developing Dry Eye After Myopic LASIK American Journal of Ophthalmology. Mar, 2006 | Pubmed ID: 16490488 Gap Junction Protein Connexin 43 Serves As a Negative Marker for a Stem Cell-containing Population of Human Limbal Epithelial Cells Stem Cells (Dayton, Ohio). May, 2006 | Pubmed ID: 16424398 JNK and ERK MAP Kinases Mediate Induction of IL-1beta, TNF-alpha and IL-8 Following Hyperosmolar Stress in Human Limbal Epithelial Cells Experimental Eye Research. Apr, 2006 | Pubmed ID: 16202406 Cell Size Correlates with Phenotype and Proliferative Capacity in Human Corneal Epithelial Cells Stem Cells (Dayton, Ohio). Feb, 2006 | Pubmed ID: 16123387 Matrix Metalloproteinases in Corneal Inflammation The Ocular Surface. Oct, 2005 | Pubmed ID: 17216119 Stress-activated Protein Kinase Signaling Pathways in Dry Eye and Ocular Surface Disease The Ocular Surface. Oct, 2005 | Pubmed ID: 17216108 Hyperosmolar Saline is a Proinflammatory Stress on the Mouse Ocular Surface Eye & Contact Lens. Sep, 2005 | Pubmed ID: 16163009 Effect of Experimental Dry Eye on Tear Sodium Concentration in the Mouse Eye & Contact Lens. Jul, 2005 | Pubmed ID: 16021005 Therapy of Progressive Rheumatoid Arthritis-associated Corneal Ulceration with Infliximab Cornea. Aug, 2005 | Pubmed ID: 16015096 Partial Enrichment of a Population of Human Limbal Epithelial Cells with Putative Stem Cell Properties Based on Collagen Type IV Adhesiveness Experimental Eye Research. Apr, 2005 | Pubmed ID: 15781286 Doxycycline Inhibits TGF-beta1-induced MMP-9 Via Smad and MAPK Pathways in Human Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. Mar, 2005 | Pubmed ID: 15728539 Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye The American Journal of Pathology. Jan, 2005 | Pubmed ID: 15632000 ABCG2 Transporter Identifies a Population of Clonogenic Human Limbal Epithelial Cells Stem Cells (Dayton, Ohio). 2005 | Pubmed ID: 15625123 Topical Cyclosporine Inhibits Conjunctival Epithelial Apoptosis in Experimental Murine Keratoconjunctivitis Sicca Cornea. Jan, 2005 | Pubmed ID: 15604871 Stimulation of Matrix Metalloproteinases by Hyperosmolarity Via a JNK Pathway in Human Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. Dec, 2004 | Pubmed ID: 15557436 Experimental Dry Eye Stimulates Production of Inflammatory Cytokines and MMP-9 and Activates MAPK Signaling Pathways on the Ocular Surface Investigative Ophthalmology & Visual Science. Dec, 2004 | Pubmed ID: 15557435 Phenotypic Characterization of Human Corneal Epithelial Cells Expanded Ex Vivo from Limbal Explant and Single Cell Cultures Experimental Eye Research. Jul, 2004 | Pubmed ID: 15183099 Characterization of Putative Stem Cell Phenotype in Human Limbal Epithelia Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 15153612 Management of the Late Ocular Sequelae of Stevens-Johnson Syndrome The Ocular Surface. Oct, 2003 | Pubmed ID: 17075650 The Ocular Surface Center at the Baylor College of Medicine, Houston The Ocular Surface. Apr, 2003 | Pubmed ID: 17075639 Anti-inflammatory Therapy of Dry Eye The Ocular Surface. Jan, 2003 | Pubmed ID: 17075627 Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies (Video) | JoVE Remya Ammassam Veettil1, Wei Li1, Stephen C. Pflugfelder1, Douglas D. Koch1 1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine JoVE 65289 生物学
Decoding Corneal Neovascularization with Alkali Burn Model for Future Therapeutic Strategies (Video) | JoVE Remya Ammassam Veettil1, Wei Li1, Stephen C. Pflugfelder1, Douglas D. Koch1 1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine JoVE 65289 生物学